CAS: 3235-69-6; Morpholin-4-Yl-Acetic Acid

上下游产品

CAS号3235-82-3 2-(4-吗啉基)乙酸乙酯 | CAS号35855-10-8 4-吗啉基乙酸甲酯 | CAS号53342-23-7 4-吗啉乙酸苯基甲酯 | CAS号110-91-8 吗啉 | CAS号5292-43-3 溴乙酸叔丁酯 | CAS号88217-68-9 tert-butyl 2-mo... | CAS号79-08-3 溴乙酸 | CAS号5625-90-1 N,N'-亚甲基双吗啉 | CAS号151-50-8 氰化钾 | CAS号3926-62-3 氯乙酸钠 | CAS号125762-97-2 [(2S,3S,5R)-3-a... | CAS号50618-82-1 4-Morpholinylac...

专利信息

专利号:US-10464958-B2
优先权日:2012-07-17
标题 :Method for the synthesis of alpha-aminoalkylenephosphonic acid
发明人：NOTTE PATRICK; COGELS SAMUEL; BURCK SEBASTIAN
权利人:MONSANTO TECHNOLOGY LLC
摘要:The present invention is related to a new method for the synthesis of alpha-aminoalkylenephosphonic acid or its phosphonate esters comprising the steps of forming a reaction mixture by mixing a P—O—P anhydride moiety comprising compound, having one P-atom at the oxidation state (+III) and the other P-atom at the oxidation state (+III) or (+V), an aminoalkanecarboxylic acid and an acid catalyst, wherein said reaction mixture comprises an equivalent ratio of alpha-aminoalkylene carboxylic acid to P—O—P anhydride moieties of at least 0.2, and recovering the resulting alpha-aminoalkylene phosphonic acid compound or an ester thereof from the reaction mixture.

专利号:WO-2023207921-A1
优先权日:2022-04-25
标题 :Taxamairin analogs and methods of preparation and use thereof
发明人：LEE CHI SING; GE SIYUAN; ZHUANG ANDREW-GO
权利人:UNIV HONG KONG BAPTIST UNIV
摘要:Taxamairin analogs useful in the treatment of cancer, pharmaceutical compositions including the same, methods of use thereof, and methods of preparation are provided. An efficient and scalable semi-synthesis of taxamairin compounds and analogs thereof from readily available commercial starting materials is provided. The synthesis involves low cost and relatively non-toxic reagents and is capable of synthesizing taxamairin A and taxamairin B and analogs thereof on multi-gram scale in yields up 12%and 21%, respectively.

专利号:US-9822145-B2
优先权日:2014-10-27
标题:Methods of making carfilzomib and intermediates thereof
发明人：KOVI RAVISHANKER; KANNAPAN JAYARAMAN; RAMU VASANTHAKUMAR G; PRASAD ALAPARTHI LAKSHMI; CHOWDARY TALLURI BHUSHAIAH; KULKARNI GAURAV; AHMED SAIYED AKEEL AHMED SHAKEEL; BOBBILI VEERABHADRA RAO; DUSANAPUDI N V RAGHAVALU; MANTRI ANAND V
权利人:APICORE US LLC
摘要:Racemization-free methods are disclosed for the synthesis of carfilzomib. Novel intermediates and methods of making carfilzomib employing fragment condensation using the novel intermediates are disclosed. Amorphous carfilzomib and methods of making same are disclosed.

专利号:US-2018346497-A1
优先权日:2012-07-17
标 题:Method for the synthesis of alpha-aminoalkylenephosphonic acid

专利号:EP-3041856-A1
优先权日:2013-09-06
标题 :Synthesis of peptide epoxy ketones

专利号:CN-104812765-B
优先权日:2012-07-17
标题 :Process for the synthesis of alpha-aminoalkylenephosphonic acid