CAS: 470-67-7; 1-Isopropyl-4-Methyl-7-Oxabicyclo[2.2.1]Heptane

该化合物是一种无色液体,具有独特的新鲜,薄荷芳香,是一种单体和环状醚,主要存在于eucalyptus油和其他基本油中.1,4-cineole的分子配方为C10H18O,具有双环结构,有助于其独特的特性.该化合物以其香味著称,在香味和口味行业以及药用应用中常用,因其潜在的反炎和抗微生物特性.1,4-氯乙烯在有机溶剂中溶解,但水溶解度有限.它有一个相对较低的沸点,并且具有挥发性,在各种应用中有用,包括溶剂和个人护理产品的配制.此外,已经研究过它的潜在治疗效果,特别是呼吸卫生方面,因为它可能有助于缓解拥塞和改善空气流.但是,应当采取安全防范措施,因为它可以对皮肤和肌肉产生刺激.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号99-86-5 α-松油烯 | CAS号470-82-6 桉叶油醇 | CAS号562-74-3 4-萜烯醇 | CAS号512-85-6 阿斯利多 | CAS号78-79-5 异戊二烯 | CAS号565-48-0 4-p-樟烷-1,8-二醇 | CAS号7664-93-9 硫酸 | CAS号98-55-5 alpha-松油醇 | CAS号7664-38-2 磷酸 | CAS号562-74-3 4-萜烯醇

合成工艺路线路线简述

    Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于硫酸体系中,化学反应生成 1,4-桉叶素
    参考文献:Matuura,1938,Vol. 8,P. 303,309
    标题:Matuura,1938,Vol. 8,P. 303,309

    海关参考信息

    专利信息


    专利号:WO-2012088402-A1
    优先权日:2010-12-22
    标题 :Synthesis of conolidine and discovery of a potent non-opioid analgesic for pain
    发明人:BOHN LAURA M; MICALIZIO GLENN C
    权利人:SCRIPPS RESEARCH INST; BOHN LAURA M; MICALIZIO GLENN C
    摘要:The first de novo synthetic pathway to the exceptionally rare C5-nor stemmadenine natural product, conolidine, and the first asymmetric synthesis of any member of this natural product class arc described. C5-nor stemmadenine compositions are also described. These compounds, for example,(+/- )-,(+)- and (-)-conolidine are potent and efficacious non-opioid analgesics in tonic and persistent pain.

    专利号:US-7700783-B2
    优先权日:2003-10-09
    标题 :Synthesis of discodermolide and variants thereof
    发明人:SMITH III AMOS B; FREEZE BRIAN SCOTT; XIAN MING
    权利人:UNIV PENNSYLVANIA
    摘要:Processes for synthesizing a compound of Formula (I) are provided by reacting a compound of Formula (i) with a compound of Formula (xx).

    专利号:US-2005209355-A1
    优先权日:2004-03-22
    标 题:[Novel Reactions and the Products of Such Reactions]
    发明人:ROITMAN LIPA L
    权利人:ROITMAN LIPA L
    摘要:A process for the synthesis of novel compounds is described comprising reacting tetrachloroethylene with substances containing active methylene group in the presence of free radical initiators. Also, a process for grafting tetrachloroethylene is described comprising reacting these compounds with polymers containing active methylene group in the presence of free radical initiators. Furthermore, a method of conducting such reactions to high conversion is described, comprising conducting the reactions in the reflux condensate. The present invention provides a novel and high yield route for heretofore unobtainable materials.

    专利号:US-5922335-A
    优先权日:1995-05-15
    标 题:Uses for ascorbyl-phosphoryl-cholesterol in topical compositions
    发明人:PTCHELINTSEV DMITRI
    权利人:AVON PROD INC
    摘要:Novel uses of 3'-(L-ascorbyl-2-o-phosphoryl)-cholesterol, 3'-(L-ascorbyl-3-o-phosphoryl)-cholesterol, structural or functional isomers thereof and salts thereof (referred to collectively as 'APC compounds') are disclosed. Such novel uses include a method of reducing epidermal synthesis of abnormal elastin, especially epidermal synthesis of abnormal elastin that results from exposure to UV radiation. Also disclosed is a novel method of stimulating keratinocyte formation of triglycerides. In addition, a novel method of achieving antioxidant activity, both in the skin and also in topical compositions, is disclosed.

    专利号:US-11866443-B2
    优先权日:2017-05-19
    标 题:Method for separating optically active hydroxy cineole derivatives
    发明人:DITRICH KLAUS; RACK MICHAEL; BENSON STEFAN; GOETZ ROLAND; KRAUS HELMUT
    权利人:BASF AGRO BV
    摘要:The present invention relates to a method for separating an optically active hydroxy cineole derivatives by lixiviation and crystallization and enantiomerically pure optically active hydroxy cineole derivatives of purity greater than 99.5% that have been prepared by this process. The present invention further relates to use of the desired enantiomer having enantiomeric excess of at least 99.5% ee as prepared according to the present invention, for the synthesis of enantiomerically pure 7-oxabicyclo[2.2.1]heptane derivatives.

    专利号:US-11596930-B2
    优先权日:2020-04-08
    标 题 :Nickel/titanium oxide-silicon oxide catalyst for synthesizing terpinene-4-ol, preparation method thereof, and method of synthesizing terpinene-4-ol using the same
    发明人:ZHENG HUIDONG; WU DAN; CHEN JINGJING; LIU JIE; WU NAIXIN
    权利人:UNIV FUZHOU
    摘要:The present invention discloses a nickel/titanium oxide-silicon oxide catalyst for synthesizing terpinene-4-ol as well as a preparation method and method of synthesizing terpinene-4-ol using the same. The preparation method includes the steps of catalyst preparation, terpinene-4-ol synthesis and the like are disclosed in the present invention. The preparation method includes the following steps: firstly, preparing a mixed colloid of TiO2 and SiO2 by using a sol-gel method, and then centrifuging, washing, drying and roasting is performed to prepare a TiO2—SiO2 binary oxide; then, preparing Ni/TiO2-SiO2 by dipping in a nickel nitrate solution, and preparing a supported catalyst by drying and roasting; and finally, adopting a terpinolene-4, 8-epoxide a raw material, carrying out isomerization under the dual catalytic action of TiO2-SiO2 and Ni of the supported catalyst, and carrying out hydrogenation to prepare terpinene-4-ol. The preparation method can combine isomerization and hydrogenation reaction on the same catalyst, has good selectivity on terpinene-4-ol, and is simple to operate and high in product yield.
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    合成参考文献


    参考文献:10.1023/a:1010462309244
    摘要:Epple G, Bryant BP, Mezine I, Lewis S. Zanthoxylum piperitum, an Asian Spice, Inhibits Food Intake in Rats. Journal of Chemical Ecology. 2001 Aug;27(8):1627–40. doi: 10.1023/a:1010462309244.
    参考文献:10.1007/s10886-006-9075-2
    摘要:Iason GR, Villalba JJ. Behavioral Strategies of Mammal Herbivores Against Plant Secondary Metabolites: The Avoidance–Tolerance Continuum. Journal of Chemical Ecology. 2006 May 23;32(6):1115–32. doi: 10.1007/s10886-006-9075-2.
    参考文献:10.1007/s10886-006-9076-1
    摘要:Wiggins NL, McArthur C, Davies NW, McLean S. Behavioral Responses of a Generalist Mammalian Folivore to the Physiological Constraints of a Chemically Defended Diet. Journal of Chemical Ecology. 2006 May 04;32(6):1133–47. doi: 10.1007/s10886-006-9076-1.
    参考文献:10.1007/s10886-006-9080-5
    摘要:Green AK, Haley SL, Barnes DM, Dearing MD, Karasov WH. Is alpha-Pinene a Substrate for Permeability-Glycoprotein in Wood Rats Journal of Chemical Ecology. 2006 May 23;32(6):1197–211. doi: 10.1007/s10886-006-9080-5.
    参考文献:10.1007/s10886-006-9081-4
    摘要:McLean S, Duncan AJ. Pharmacological Perspectives on the Detoxification of Plant Secondary Metabolites: Implications for Ingestive Behavior of Herbivores. Journal of Chemical Ecology. 2006 May 23;32(6):1213–28. doi: 10.1007/s10886-006-9081-4.
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