CAS: 52200-48-3; 3-Bromo-2-Chloropyridine

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2-氯-3-三甲基甲硅烷基吡啶置于溴体系中,用 四氯化碳 作为反应溶剂,化学反应 75.0H,以92%的收率获得产物3-溴-2-氯吡啶
参考文献:三氟甲基取代的吡啶羧酸和喹啉羧酸的推荐路线
标题:三氟甲基取代的吡啶羧酸和喹啉羧酸的推荐路线
摘要:作为案例研究的一部分,准备的合理策略.所有 10 种 2-,3-或 4-吡啶羧酸和所有 9 种在 2-,3-或 4-位带有三氟甲基取代基的 2-,3-,4-或 8-喹啉羧酸中的 如果前体中尚未存在三氟甲基,则通过用四氟化硫对合适的羧酸进行脱氧氟化或通过原位反应生成的三氟甲基铜置换环结合的溴或碘来引入三氟甲基.羧基功能是通过用二氧化碳处理有机锂或有机镁中间体,卤素/金属或氢/金属置换的产物而产生的.[在 Scifinder (R) 上]
DOI:10.1002/ejoc.200390215

专利信息

专利号:US-6635767-B2
优先权日:2000-05-23
标 题 :Synthesis of heteroarylamine intermediate compounds
发明人：SONG JINHUA J; YEE NATHAN K; KAPADIA SURESH R
权利人:BOEHRINGER INGELHEIM PHARMA
摘要:Disclosed are novel 2-(5-halopyridyl) and 2-(5-halopyrimidinyl) magnesium halides, processes of making and their use in the efficient synthesis in their respective 5-halo-2-substituted pyridines and pyrimidines.

专利号:US-6822093-B2
优先权日:2000-05-23
标题 :Synthesis of heteroarylamine intermediate compounds
发明人：SONG JINHUA J; YEE NATHAN K
权利人:BOEHRINGER INGELHEIM PHARMA
摘要:Disclosed are novel 2-(5-halopyridyl) and 2-(5-halopyrimidinyl) magnesium halides, processes of making and their use in the efficient synthesis in their respective 5-halo-2-substituted pyridines and pyrimidines.

专利号:US-7884125-B2
优先权日:2008-04-30
标 题:Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues
发明人：STEVENS CHRISTIAN; HEUGEBAERT THOMAS
权利人:UNIV GENT
摘要:The present invention relates to a group of substituted-7-azabicyclo-[2.2.1]heptyl derivatives with biological activity. The present invention also relates to synthetic methods for producing said substituted-7-azabicyclo-[2.2.1]heptyl derivatives. The present invention also relates to certain intermediates for producing such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as a synthetic method for producing such intermediates. The present invention also relates to pharmaceutical compositions comprising such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as their use as medicaments for the treatment of diseases mediated by a Nicotinic Acetylcholine Receptor or a receptor being a member of the Neurotransmitter-gated Ion Channel Superfamily, such as pain, Alzheimer's disease, Parkinson's disease, schizophrenia, epilepsy and nicotine addiction.

专利号:US-2009275616-A1
优先权日:2008-04-30
标 题 :Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues

专利号:CA-2424916-C
优先权日:2000-05-23
标 题:Novel synthesis of heteroarylamine intermediate compounds

专利号:EP-1409460-B1
优先权日:2000-05-23
标题:Novel synthesis of heteroarylamine intermediate compounds