CAS: 5779-93-1; 2,3-Dimethylbenzaldehyde

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CAS号5724-56-1 2,3-二甲基苯腈 | CAS号81093-21-2 2,3-二甲基苄基溴 | CAS号13651-14-4 2,3-二甲基苄醇 | CAS号68717-07-7 5-tert-butyl-2,... | CAS号95-47-6 邻二甲苯 | CAS号201230-82-2 carbon monoxide | CAS号526-73-8 1,2,3-三甲苯 | CAS号64-19-7 冰醋酸 | CAS号87-59-2 2,3-二甲基苯胺 | CAS号603-79-2 2,3-二甲基苯甲酸 | CAS号1963-30-0 2,3-DIMETHYLCIN... | CAS号32281-65-5 3,4-Dihydro-5,6... | CAS号176721-01-0 ALPHA-(2,3-二甲基苯... | CAS号60907-90-6 1-(2,3-二甲基苯基)乙醇 | CAS号625437-38-9 N-(2,3-二甲基苄基)环丙胺盐酸盐

2,3-二甲基苯胺置于lithium Aluminium Tetrahydride,氢溴酸,Magnesium,Pyridinium Chlorochromate体系中,用 乙醚,二氯甲烷 作为反应溶剂,化学反应 7.0H,反应生成 2,3-二甲基苯甲醛
参考文献:Aromatische Spirane,20. Mitt.: Darstellung Von Dimethylsubstituierten 2-Carboxymethyl-Indan-1-Onen Und Benzylchloriden Als Synthone Fr Synthesen Von Di-Bis Tetramethylierten 2,2-Spirobiindandionen
标题:Aromatische Spirane,20. Mitt.: Darstellung Von Dimethylsubstituierten 2-Carboxymethyl-Indan-1-Onen Und Benzylchloriden Als Synthone Fr Synthesen Von Di-Bis Tetramethylierten 2,2-Spirobiindandionen
摘要:The Isomeric Dimethyl Methylbenzoates 5,Obtained From The Bromides Via Grignard Reactions With Dimethylcarbonate,Were Reduced With Lialh4 To The Hydroxymethyl Derivatives 6. The Latter Were Then Transformed Both To The Benzylchlorides 7 (With Socl2) And To The Aldehydes 8 (With Pyridinium Chlorochromate). Knoevenagel-Doebner Reaction Of 8 Afforded The Acrylic Acids 9 Which (After Hydrogenation To 11) Were Cyclized To The Desired Indanones 12 With Polyphosphoric Acid. On The Other Hand,12C And 12E Were Prepared From Dimethyl 3-Chloropropiophenone (14) By Warming With Sulfuric Acid. After Nah-Catalyzed Reaction With Dimethylcarbonate,The Indanones 12 Gave The Ketoesters 15 Which Then Could Be Hydrogenated To The Indanes 16. All Reactions Proceeded With Satisfactory To Excellent Yields (60-90%).
DOI:10.1007/bf00807400