CAS: 6089-09-4; 4-Pentynoic Acid

相似化合物

5390-04-5 19596-07-7 63093-41-4

上下游产品

prop-2-yn-1-ylpropanedioic acid pent-1-yn-5-ol 4,5-dibromopentanoic acid diethyl propargylmalonate methyl pent-4-ynoate 7-cyclohex-1-enyl-hepta-4,6-diynoic acid 5-methyl-2-furanone (E)-2,4-pentadienoic acid

4-戊炔-1-醇 反应生成 炔丙基脲
参考文献:Neuroprotectin D1/protectin D1 及其阿司匹林触发立体异构体的立体控制全合成
标题:Neuroprotectin D1/protectin D1 及其阿司匹林触发立体异构体的立体控制全合成
摘要:Neuroprotectin D1/protectin D1 是一种从二十二碳六烯酸生物合成衍生的强效抗炎,促分解和神经保护脂质介质,通过全有机合成以对映体纯形式制备.合成策略是高度立体控制和收敛的,以缩水甘油起始材料的环氧化物开环为特征,以引入 10(R) 和 17(S) 羟基.通过炔前体的顺式还原来确保所需的烯烃z几何结构,而在末端引入共轭e,E,Z三烯,以最小化z / E异构化.相同的策略也用于具有 17(R)-立体化学的阿司匹林触发的神经保护素 D1/保护素 D1 的全合成.用所报告的方法获得的合成化合物与内源性材料相匹配,并有助于建立完整的立体化学.
DOI:10.1016/j.Tetlet.2012.01.032

专利信息

专利号:US-10919904-B2
优先权日:2016-08-17
标 题 :Northern-southern route to synthesis of bacteriochlorins
发明人：LIU YIZHOU; LINDSEY JONATHAN S; ALLU SRINIVASA RAO; FUJITA HIKARU
权利人:UNIV NORTH CAROLINA STATE
摘要:Described herein are chlorins, bacteriochlorins, methods and intermediates for the synthesis of bacteriochlorins, and methods of using such bacteriochlorins for, among other things, diagnostic and therapeutic purposes such as luminescent compounds in flow cytometry, and as active agents in photodynamic therapy (PDT).

专利号:US-5705659-A
优先权日:1994-09-30
标 题 :Intermediates for the synthesis of 16-phenoxy-prostatrienoic acid derivatives and a preparing method thereof
发明人：PARK HOKOON; JUNG SUN HO; LEE YONG SUP; NAM KI HONG
权利人:KOREA INST SCI & TECH
摘要:Intermediate compounds represented as formula (I) useful for the synthesis of 16-phenoxy-prostatrienoic acid derivatives and a preparing method thereof are disclosed. ##STR1## wherein R is tetrahydropyranyl, tetrahydrofuranyl, 2-ethoxyethyl, t-butyldimethylsilyl, triisopropylsilyl or triethylsilyl group; R 1 and R 2 are independently hydrogen or ester-forming group; P is hydrogen, trimethylsilyl or tri-n-butyltin; and wavy line means epi-stereoisomeric mixture.

专利号:US-4958037-A
优先权日:1985-07-29
标题 :Precursors and synthesis of methyl-9-oxo-11α, 16-dihydroxy-16-vinyl-5-cis-13-trans-prostadienoates
发明人：FLOYD JR MIDDLETON B
权利人:AMERICAN CYANAMID CO
摘要:Novel precursors for the synthesis of methyl-9-oxo-11 alpha ,16-dihydroxy-16-vinyl-5-cis-13-trans prostadienoates having the formulae (2) (3) (4a) (4b) wherein R1 is H or C1-C4 alkyl; R2 is C1-C4 alkyl, R3 is H, C1-C4 trialkylsilyl or C1-C6 alkyl; X1 is halogen, cyano, C1-C4 alkoxycarbonyl, carboxy or tri (C1-C4 alkoxy)methyl; n is 2-4 inclusive; and P1 is H or a blocking or protective group; congeners and racemic mixture of these compounds and processes of synthesizing them.

专利号:WO-2019197122-A1
优先权日:2018-04-10
标 题:Process for treatment of at least one cell with a chemical synthesis product in a microarray
发明人：BENZ MAXIMILIAN; LEVKIN PAVEL A; MOLLA MIJANUR R; ROSENFELD ALISA; BREHM MARIUS
权利人:KARLSRUHER INST TECHNOLOGIE
摘要:The present invention relates to a process for treatment of at least one cell with a chemical synthesis product in a microarray, a stacked microarray, a kit comprising at least one microarray and the use of a microarray for the chemical synthesis of a chemical synthesis product and for the treatment of at least one cell with the chemical synthesis product in a microarray.

专利号:US-8951728-B2
优先权日:2004-11-22
标 题:Template directed split and mix synthesis of small molecule libraries
发明人：RASMUSSEN PETER BIRK
权利人:CHEMGENE HOLDING APS
摘要:The invention combines the advantages of split and mix synthesis with the advantages of template directed synthesis. The method comprises the steps of: a) adding a linker molecule L to one or more reaction wells; b) adding a molecule fragment to each of said reaction wells; c) adding an oligonucleotide identifier to each of said reaction wells; d) subjecting said wells to conditions sufficient to allow said molecule fragments and said oligonucleotide identifiers to become attached to said linker molecule, or conditions sufficient for said molecule fragments to bind to other molecule fragments and sufficient for said oligonucleotide identifiers to bind to other oligonucleotide identifiers; e) combining the contents of said one or more reaction wells; and f) contacting the resulting bifunctional molecule(s) of step e) with one or more (oligonucleotide) templates each capable of hybridizing to at least one of the oligonucleotide identifiers added in step c).

专利号:US-10029014-B2
优先权日:2013-09-10
标题:Synthesis of novel asymmetric bow-tie PAMAM dendrimer-based conjugates for tumor-targeting drug delivery
发明人：OJIMA IWAO; WANG TAO; TENG YU-HAN
权利人:UNIV NEW YORK STATE RES FOUND
摘要:The present disclosure relates to a dendrimer-based conjugate of the formula V m -D-C-D′-(T-F) n , which is useful for tumor targeting drug delivery. The use of asymmetric dendrimers allow for specific targeting as well as synthetic reproducibility.