CAS: 62561-74-4; (R)-2-Amino-3-(4-Bromophenyl)Propanoic Acid

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CAS号14091-15-7 DL-4-溴苯丙氨酸 | CAS号589-15-1 对溴溴苄 | CAS号119838-18-5 (2R,5R)-5-p-bro... | CAS号1200-07-3 对溴肉桂酸

(Z)-3-(4-Bromophenyl)-2-Hydroxyacrylic Acid置于葡萄糖,Nicotinamide Adenine Dinucleotide Phosphate,氯化铵体系中,用 甲醇 作为反应溶剂,化学反应 24.0H,以69%的收率获得产物d-4-溴苯丙氨酸
参考文献:利用工程化的d-氨基酸脱氢酶的对映体纯d-芳基丙氨酸的单一生物催化剂合成
标题:利用工程化的d-氨基酸脱氢酶的对映体纯d-芳基丙氨酸的单一生物催化剂合成
摘要:基于相应的α-酮酸通过由工程脱氢酶和辅因子回收装置组成的重组全细胞系统的还原胺化反应,已开发出一种实用,有效的芳香族d-氨基酸生物催化合成方法.结果表明,在制备规模上,该反应在多种底物上均具有出色的对映选择性(>=98%)和非常好的收率.另外,解析了变体酶的结构以使观测到的反应速率合理化.工程化的全细胞催化剂还通过与对映体互补脱氨酶结合使用,来介导外消旋混合物和更便宜的l-氨基酸产生的d-苯丙氨酸衍生物.
DOI:10.1002/adsc.201600682

专利信息

专利号:US-2022243244-A1
优先权日:2019-10-10
标 题 :Compositions and methods for in vivo synthesis of unnatural polypeptides
发明人：ROMESBERG FLOYD E; FISCHER EMIL C; HASHIMOTO KOJI; FELDMAN AARON W; DIEN VIVIAN T; ZHANG YORKE
权利人:SCRIPPS RESEARCH INST
摘要:Disclosed herein are compositions, methods, and kits for a cell incorporating unnatural amino acids into an unnatural polypeptide. Also disclosed herein are compositions, methods, and kits for increasing activity and yield of the unnatural polypeptide synthesized by the cell.

专利号:US-2023037284-A9
优先权日:2018-11-30
标题:Combination therapy of peptidomimetic macrocycles
发明人：GUERLAVAIS VINCENT; ANNIS DAVID ALLEN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

专利号:US-2025084410-A1
优先权日:2015-01-12
标 题:Incorporation of unnatural nucleotides and methods thereof
发明人：PTACIN JEROD; MALYSHEV DENIS A; CAFFARO CAROLINA E
权利人:SYNTHORX INC
摘要:Disclosed herein are methods, compositions and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA.

专利号:US-2018371021-A1
优先权日:2017-05-11
标 题 :Peptidomimetic macrocycles and uses thereof
发明人：AIVADO MANUEL; GUERLAVAIS VINCENT; OLSON KAREN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

专利号:WO-2021072167-A1
优先权日:2019-10-10
标 题:Compositions and methods for in vivo synthesis of unnatural polypeptides

专利号:US-11091522-B2
优先权日:2018-07-23
标题 :Peptidomimetic macrocycles and uses thereof
发明人：AIVADO MANUEL; GUERLAVAIS VINCENT; OLSON KAREN; ANNIS DAVID ALLEN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.