CAS: 6443-85-2; 2-(Pyridin-3-yl)Acetonitrile

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α-Phenylsulfonyl-3-Pyridineacetonitrile置于锌体系中,用 乙醇,溶剂黄146 作为反应溶剂,化学反应 1.0H,以97%的收率获得产物3-吡啶乙腈
参考文献:Palladium-Catalyzed Condensation Of Aryl Halides With Phenylsulfonylacetonitrile And Diethyl Cyanomethylphosphonate.
标题:Palladium-Catalyzed Condensation Of Aryl Halides With Phenylsulfonylacetonitrile And Diethyl Cyanomethylphosphonate.
摘要:用钯(0)催化的芳香卤化物与苯基磺酰乙腈和二乙基氰基甲基膦酸钠在二甲氧基乙烷中缩合,得到相应的α-苯基磺酰芳烃乙腈和二乙基芳氰基甲基膦酸酯,产率非常好.α-苯基磺酰芳烃乙腈可以用锌轻松去磺化反应生成芳烃乙腈,而芳氰基甲基膦酸酯通过霍纳-艾蒙斯反应转化为烷基亚烯芳烃乙腈.
DOI:10.1248/cpb.38.1513

专利信息

专利号:WO-2022170218-A1
优先权日:2021-02-05
标题:Intramolecular cyclization for general synthesis of bicyclic alkyl bioisostere boronates
发明人：QIN TIAN; YANG YANGYANG; TSIEN JET
权利人:UNIV TEXAS
摘要:Disclosed herein are methods of synthesizing compounds of the formula (I) wherein the variables are defined herein. Also provided are compounds produced using these methods. In some aspects, the methods provided herein may be used to install aryl bioisosteres.

专利号:US-4369322-A
优先权日:1978-12-15
标 题 :Process for the production of substituted acetonitriles
发明人：SCHALKE PETER; KLEEMANN AXEL
权利人:DEGUSSA
摘要:The known synthesis for the production of aromatic substituted acetonitriles by reaction of aromatic substances with cyanogen chloride in the gas phase is improved by feeding the starting materials in gaseous form and separated from each other into the reactor. The process can be used to synthesize in general aromatic and especially hetero-aromatic substituted acetonitrile.