CAS: 70671-54-4; Z-D-Lys-Oh

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D-赖氨酸盐酸盐置于lithium Hydroxide,Sodium Hydroxide体系中,用 乙醇 作为反应溶剂,化学反应 0.5H,反应生成 Cbz-D-赖氨酸
参考文献:Stereocontrolled Synthesis Of Onchidins
标题:Stereocontrolled Synthesis Of Onchidins
摘要:(Graphics)The First Total Synthesis Of A Molecule Possessing The Stereochemistry Proposed For Onchidin Is Described. The Structure Synthesized Appears To Be Different From That Of The Marine Natural Product.
DOI:10.1021/ol048437P

专利信息

专利号:EP-0406931-B1
优先权日:1989-06-30
标 题 :New analogues of all-bond retroinverted thymopentin, the method for the synthesis of the same and their employment for the preparation of pharmaceutical compositions
发明人：MARIOTTI SABINA; SISTO ALESSANDRO; NENCIONI LUCIANO; VILLA LUIGI; PESSI ANTONELLO
权利人:SCLAVO SPA
摘要:New thymopentin (TP5) analogues whose bonds in the peptide chain are all retro-inverted are disclosed. Such new compounds have the following general formula (I) wherein R is hydrogen or an acyl radical, and R<1> is a group of the formula -OR<2>, wherein R<2> is a hydrogen atom or a hydrocarbon radical, and the corresponding basic or acid addition salts which are pharmaceutically acceptable. The new compounds have immunostimulating activity.

专利号:EP-0406931-A2
优先权日:1989-06-30
标题 :New analogues of all-bond retroinverted thymopentin, the method for the synthesis of the same and their employment for the preparation of pharmaceutical compositions

专利号:CA-2020129-A1
优先权日:1989-06-30
标题:Analogues of all-bond retroinverted thymopentin, the method for the synthesis of the same and their employment for the preparation of pharmaceutical compositions

专利号:WO-2023033016-A1
优先权日:2021-09-01
标 题 :Arginine derivative
发明人：YANO SHINYA; MATSUMOTO SUGURU
权利人:SEKISUI MEDICAL CO LTD
摘要:Provided are: a guanidyl-protected arginine compound which, when used in a liquid-phase peptide synthesis reaction, renders satisfactory liquid-liquid separation possible; and a peptide synthesis method in which the guanidyl-protected arginine compound is used.　The present invention relates to an arginine derivative represented by formula (1), (2), or (3) or a salt thereof. (In the formulae, R1 and R2 are the same or different and each represent a hydrogen atom or a C1-C4 alkyl group, A represents a hydrogen atom or an amino-protecting group, R3 and R4 each represent a hydrogen atom or a Boc group, with the proviso that at least one of them is a Boc group, R5 and R6 each represent a hydrogen atom or a Boc group, with the proviso that at least one of theme is a Boc group, R7 and R8 each represent a hydrogen atom or a Boc group, with the proviso that at least one of them is a Boc group, and n represents an integer of 1-6 (with the proviso that the case where n is 3, R1 and R2 are each a hydrogen atom or a methyl group, and R3 to R8 are Boc groups is excluded).)