CAS: 95635-56-6; N-(2,6-Dimethylphenyl)-2-(4-(2-Hydroxy-3-(2-Methoxyphenoxy)Propyl)Piperazin-1-yl)Acetamide Dihydrochloride

• 英文名称N-(2,6-Dimethylphenyl)-2-(4-(2-Hydroxy-3-(2-Methoxyphenoxy)Propyl)Piperazin-1-yl)Acetamide Dihydrochloride
• 中文名称盐酸雷诺嗪
• IUPAC名称N-(2,6-dimethylphenyl)-2-(4-(2-hydroxy-3-(2-methoxyphenoxy)propyl)piperazin-1-yl)acetamide dihydrochloride
• 其它别名N-(2,6-Dimethylphenyl)-2-[4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl]acetamide dihydr°Chloride
• CAS编号95635-56-6
• MFCD编号:MFCD03788770
• EINECS号:815-607-3
• FDA UNII编号:F71253DJUN
• 分子式:C24H35Cl2N3O4
• 分子量:500.47
• 产品CID: 2009782
• 同类组份化合物CAS95635-55-5 (free base)95635-56-6 (HCl)
• 产品分类生物化工 → 抑制剂 → 跨膜转运蛋白 → 钙通道抑制剂

• 相似结构搜索
• 产品信息参考;;;;
• InChIKey: RJNSNFZXAZXOFX-UHFFFAOYNA-N
• InChI=1S/C24H33N3O4.2ClH/c1-18-7-6-8-19(2)24(18)25-23(29)16-27-13-11-26(12-14-27)15-20(28)17-31-22-10-5-4-9-21(22)30-3;;/h4-10,20,28H,11-17H…
• 计算化学: 氢键受体数6.0氢键供体数4.0可旋转键数9.0

物理性质

• 熔点222-229.5 °C(文献)
• 沸点624.1 °C at 760 mmHg
• 闪点331.2 °C
• PSA:74.27
• LogP:3.8608
• 蒸汽压1.94E-16 mmHg at 25 °C
• 溶解性水: 10 mg/mL, Soluble
• 外观形态类白色固体
• 储存条件干燥,室温
• 产品应用该化合物用于调节心肌新陈代谢.

MSDS等安全信息

• GHS符号GHS07
• 警示词Warning
• 危险描述H315-H319
• 防范说明P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
• UN编号NONH for all modes of transport
• 安全声明22-24/25
• WGK Germany3

合成工艺路线路线简述

• 2210-74-4 + 5294-61-1 = 95635-56-6
  反应条件:1.1 Solvents: Isopropanol,Toluene; 2 H,Reflux1.2 Reagents: Hydrochloric Acid Solvents: Ethanol,Acetone; Cooled
  标题:Process For Preparation Of Ranolazine
  参考文献:China]
  
  2210-74-4 + 5294-61-1 = 95635-56-6
  反应条件:1.1 Solvents: Toluene; 3 H,Reflux1.2 Reagents: Hydrochloric Acid Solvents: Ethanol
  标题:Synthesis Of Anti-Angina Drug Ranolazine
  作者:Wang,Li-Sheng; Feng,Xiao-Yu; Zhu,Hong-Yuan
  参考文献:Guangxi Daxue Xuebao 日期:2003 卷标:28(4) 页码:301-303]
  
  = 95635-56-6 [标题:Reaction Conditions
  标题:Improved Process For Preparation Of Pure Ranolazine And Pharmaceutically Acceptable Salts Thereof
  参考文献:India]
  
  = 95635-56-6 [标题:Reaction Conditions
  标题:Process For Preparation Of Piperazine Derivatives
  参考文献:European Patent Organization]
  
  2210-74-4 + 5294-61-1 = 95635-56-6
  反应条件:1.1 Solvents: Ethanol; 3 - 4 H,Reflux1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 2 - 3
  标题:Study On Synthesis Process Of Ranolazine
  作者:Qin,Ming-Li; Chen,Xin-Hua; Chen,Si-Shun; Tao,Jing-Chao
  参考文献:Xinyang Shifan Xueyuan Xuebao 日期:2007 卷标:20(2) 页码:226-229]
  
  2210-74-4 + 5294-61-1 = 95635-56-6
  反应条件:1.1 Solvents: Ethanol; 3 H,Reflux; Reflux -> Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 2 - 3
  标题:Synthesis Of A Novel Antianginal Agent Ranolazine
  作者:Li,Shu-Chun; Huang,He-Qing; Li,Zhong-Jun
  参考文献:Zhongguo Yaowu Huaxue Zazhi 日期:2003 卷标:13(5) 页码:283-285]
  
  2210-74-4 + 5294-61-1 = 95635-56-6
  反应条件:1.1 Solvents: Isopropanol; Reflux; 1.5 H,Reflux1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 2
  标题:Method For Synthesizing Ranolazine
  参考文献:China]
  
  1131-01-7 + 162712-35-8 = 95635-56-6
  反应条件:1.1 Solvents: Methanol; 5 - 10 Min,Rt; Rt -> 95 °C; 4 - 5 H,90 - 95 °C; 95 °C -> 35 °C1.2 Reagents: Hydrochloric Acid Solvents: Water; Acidified
  标题:Preparation Of Ranolazine
  参考文献:World Intellectual Property Organization]
  
  2210-74-4 + 5294-61-1 = 95635-56-6
  反应条件:1.1 Solvents: Methyl Ethyl Ketone; 4 H,70 - 85 °C; 85 °C -> 30 °C1.2 Reagents: Hydrochloric Acid,Compd. With 2-Propanol (1:1); 20 - 30 °C; 2 H,20 - 30 °C
  标题:Process For Preparation Of Ranolazine And Salts Thereof
  参考文献:India]
  
  1131-01-7 + 162712-35-8 = 95635-56-6
  反应条件:1.1 Reagents: Potassium Carbonate,Sodium Iodide Solvents: Dimethylformamide; 18 H,30 - 35 °C1.2 Reagents: Water1.3 Reagents: Hydrochloric Acid Solvents: Isopropanol,Acetone; Acidified
  标题:Crystalline And Amorphous Form Of Ranolazine And The Process For Manufacturing Them
  参考文献:World Intellectual Property Organization]
  
  = 95635-56-6 [标题:Reaction Conditions
  标题:Novel Solid State Forms Of Ranolazine Salts
  参考文献:United States]
  
  = 95635-56-6 [标题:Reaction Conditions
  标题:A Process For The Preparation Of Ranolazine
  参考文献:India]
  
  = 95635-56-6 [标题:Reaction Conditions
  标题:Novel Solid State Forms Of Ranolazine Salts For Treatment Of Cardiovascular Disorders
  参考文献:World Intellectual Property Organization]
  
  = 95635-56-6 [标题:Reaction Conditions
  标题:Improved Process For The Preparation Of Ranolazine
  作者:Anonymous
  参考文献:Ip.Com Journal 日期:2009 卷标:9]
  
  = 95635-56-6 [标题:Reaction Conditions
  标题:Process For The Preparation Of Ranolazine Via Coupling Of N-(2,6-Dimethylphenyl)-1-Piperazineacetamide With 1-Methoxy-2-Oxiranylmethoxy)Benzene.
  参考文献:World Intellectual Property Organization]
  
  = 95635-56-6 [标题:Reaction Conditions
  标题:Cardioselective Aryloxy- And Arylthiohydroxypropylpiperazinyl Acetanilides Which Affect Calcium Entry
  参考文献:European Patent Organization

海关参考信息

• 2902300000-甲苯
  2905122000-异丙醇
  2905310000-1,2-乙二醇
  2905320000-1,2-丙二醇
• 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
• 详情请参考：📖 海关编码查询和海关进出口税则

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