CAS: 96-20-8; 2-Aminobutan-1-Ol

该化合物是一种带有分子式C4H11NO的手性氨基酒精(CAS 96-20-8) . 它在有机合成中,特别是在生产药品,农用化学品和特殊化学品方面,是一个多用途的中间体. 化合物的双功能性质,包括一个氨基和一个氢氧化物组,能够用于非对称合成和作为皮层或催化剂的构件. 它在极地溶剂中的中等基本性和溶解性提高了其在各种反应条件下的效用. 2-Amino-1-butanol还因其非植物特性而被用于腐蚀抑制剂和表面活性剂配方. 适当的处理建议,因为它可能会引起接触的刺激.

英文名称2-Aminobutan-1-Ol
中文名称(±)-2-氨基-1-丁醇
IUPAC名称2-aminobutan-1-ol
其它别名2-Amino-Butan-1-Ol; 2-Aminobutan-1-Ol; 2-Amino-1-Butanol, ; 1-(R,S)-(Hydroxymethyl)Propylamine; ( )-2-Amino-1-Butanol; (+)-2-Amino-1-Butanol; [(1R)-1-(Hydroxymethyl)Propyl]Ammonium; (+/-)-2-Amino-1-Butanol; R-(-)-2 Amino-1-
CAS编号96-20-8
MFCD编号:MFCD00008095
EINECS号:202-488-2
分子式:C4H11NO
分子量:89.14
产品CID: 2016648
产品分类有机原料 → 醇、酚、酚醇类化合物及衍生物

相似结构搜索
产品信息参考;;;;
InChIKey: JCBPETKZIGVZRE-UHFFFAOYNA-N
InChI=1/C4H11NO/c1-2-4(5)3-6/h4,6H,2-3,5H2,1H3…
计算化学: 氢键受体数2.0氢键供体数2.0可旋转键数2.0

MSDS等安全信息

GHS象形图
GHS符号GHS07 & GHS05 & GHS09;
注释: Exclamation mark & Corrosion & Environment
危险类别急性毒性类别4(经口)
皮肤腐蚀类别1
严重眼损伤类别1
水生急性毒性类别1
水生慢性毒性类别3
皮肤腐蚀类别1B
水生慢性毒性类别2
皮肤腐蚀/刺激类别2
严重眼刺激类别2
警示词Danger(危险)
危险描述H302 |吞咽有害.
H314 |造成严重皮肤灼伤和眼损伤.
H318 |造成严重眼损伤.
H400 |对水生生物毒性极大.
H412 |对水生生物有害并具有长期持续影响.
H411 |对水生生物有毒并具有长期持续影响.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P273-P280-P301+P312+P330-P303+P361+P353-P305+P351+P338+P310
危险等级8
UN编号UN 2735 8/PG 3
危险品标志C
包装等级III
安全声明26-36/37/39-45-61
危险类别码34-50-22
WGK Germany2

欧盟法规

REACH注册ECHA物质C&L通报REACH预注册

上下游产品

1-isobutoxymethyl-propylamine rac-2-aminobut-3-en-1-ol 2-nitro-1-butanol 2-aminobutanoic acid 2-diethylamino-butan-1-ol 2-(N,N-dimethylamino)-1-butanol 2-aminobutanoic acid 2-(1-hydroxybutan-2-yl)isoindoline-1,3-dione

合成工艺路线路线简述

609-31-4 = 96-20-8
反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol; 20 H,50 Atm,Rt; 30 Atm
标题:Chemo-Enzymatic Synthesis Of (S,S)-2,2'-(Ethylenediamino)Dibutan-1-Ol
作者:Yufryakov,V. S.; Tsvetikova,M. A.; Bystrova,N. A.; Kochetkov,K. A.
参考文献:Russian Chemical Bulletin 日期:2023 卷标:72(5) 页码:1268-1273]

609-31-4 = 96-20-8
反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol; 3 H,8 - 10 Bar,50 - 55 °C
标题:Continuous Flow Process And Apparatus For Manufacture Of Dl-2-Nitro-1-Butanol
参考文献:World Intellectual Property Organization]

2835-81-6 = 96-20-8
反应条件:1.1 Solvents: Tetrahydrofuran
标题:Reduction Of Amino Acids To Amino Alcohols With Lithium Aluminum Hydride. Ii
作者:Vogl,O.; Pohm,M.
参考文献:Monatshefte Fuer Chemie 日期:1953 卷标:84 页码:1097-1102]

193086-15-6 = 96-20-8
反应条件:1.1 Reagents: Trifluoroacetic Acid; Overnight,80 °C1.2 Reagents: Sodium Bicarbonate Solvents: Water
标题:Highly Efficient And Diastereoselective Synthesis Of 1,3-Oxazolidines Featuring A Palladium-Catalyzed Cyclization Reaction Of 2-Butene-1,4-Diol Derivatives And Imines
作者:Chen,Dongxu; Chen,Xiaoyi; Du,Taiping; Kong,Lichun; Zhen,Renwei; Et Al
参考文献:Tetrahedron Letters 日期:2010 卷标:51(39) 页码:5131-5133]

5856-63-3 = 96-20-8
反应条件:1.1 Reagents: Hydrogen Catalysts: Cobalt Solvents: 1,4-Dioxane; 5 H,3 Mpa,160 °C
标题:Racemization Of R-2-Amino-1-Butanol Catalyzed By A Fixed-Bed Raney Cobalt Catalyst
作者:Zhang,Yuecheng; Bai,Guoyi; Li,Yang; Yan,Xilong; Chen,Ligong
参考文献:Journal Of Molecular Catalysis A: Chemical 日期:2006 卷标:255(1-2) 页码:269-274]

5856-63-3 = 96-20-8
反应条件:1.1 Reagents: Hydrogen Catalysts: Nickel Solvents: Toluene; 5 H,1.7 Mpa,Rt -> 150 °C
标题:Synthesis Of Ethambutol
作者:Bai,Guo-Yi; Chen,Li-Gong; Xing,Peng; Li,Yang; Yan,Xi-Long
参考文献:Jingxi Huagong 日期:2004 卷标:21(12) 页码:943-945]

609-31-4 = 96-20-8
反应条件:1.1 Reagents: Hydrogen Catalysts: Di-μ-Chlorobis[(1,2,5,6-η)-1,5-Cyclooctadiene]Diiridium,(2R)-1-[(1R)-1-(Dimethylamino)Ethyl]-2-(Diphenylphosphino)Ferrocene Solvents: Ethanol
标题:Homogeneous Hydrogenation Of Nitro Aliphatic Compounds Catalyzed By Group Viii Transition Metal Phosphine Complexes
作者:Harsy,Stephen G.
参考文献:Tetrahedron 日期:1990 卷标:46(21) 页码:7403-12]

584-03-2 = 96-20-8
反应条件:1.1 Reagents: Sodium Carbonate Catalysts: Barium Nitrate,Cobalt Dinitrate,Ferric Nitrate,Nickel Nitrate Hexahydrate,Zirconium Nitrate Solvents: Water; Ph 7 - 8,90 °C; 60 Min,Neutralized,90 °C; 15 H,120 °C1.2 Reagents: Alumina,Nitric Acid Solvents: Water; 20 H,120 °C; 4 H,50 °C1.3 Reagents: Hydrogen; 5 H,400 °C; 5 Mpa,400 °C -> 160 °C1.4 Reagents: Ammonia Solvents: Benzene,1,4-Dioxane; 160 °C
标题:Process For Preparation Of 2-Amino-1-Alcohols From 1,2-Diols
参考文献:China]

2835-81-6 = 96-20-8
反应条件:1.1 Reagents: Iodine,Sodium Borohydride Solvents: Tetrahydrofuran; 30 Min,0 °C; Overnight,90 °C; 90 °C -> Rt1.2 Reagents: Potassium Hydroxide Solvents: Water; 4 H,Rt
标题:Highly Exo Selective,Photochemically Promoted Cyclization Of Iodoallene Derivatives
作者:Jovanovic,Milos; Simic,Milena; Petkovic,Milos; Tasic,Gordana; Maslak,Veselin; Et Al
参考文献:Journal Of Heterocyclic Chemistry 日期:2022 卷标:59(8) 页码:1435-1440]

609-31-4 = 96-20-8
反应条件:1.1 Reagents: Hydrogen Catalysts: Tetrakis(Triphenylphosphine)Palladium Solvents: Methanol; 20 H,50 Atm,Rt
标题:Method For Producing Ethambutol
参考文献:Russian Federation]

2483-62-7 = 96-20-8
反应条件:1.1 Reagents: Sodium Methoxide,Sodium Borohydride Solvents: Methanol; 20 Min,60 °C
标题:Borohydride Reduction Stabilizing System And Method For Reducing Ester Into Alcohol
参考文献:World Intellectual Property Organization]

609-31-4 = 96-20-8
反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol; 3 H,8 - 10 Bar,50 - 55 °C
标题:Continuous Flow Process And Reactor For Manufacture Of Dl-2-Nitro-1-Butanol For Production Of Dl-2-Amino-1-Butanol
参考文献:India]

5856-63-3 = 96-20-8
反应条件:1.1 Reagents: Hydrogen Catalysts: Alumina,Magnesium,Cobalt; 5 H,2.5 Mpa,170 °C
标题:Racemization Of Chiral Amino Alcohols Iii: Effect Of Mg Or Ca Addition On The Activity And Stability Of The Co/γ-Al2O3 Catalyst
作者:Bai,Guoyi; Zhang,Chenfang; Zhang,Yuecheng; Yu,Haijun; He,Fei; Et Al
参考文献:Reaction Kinetics And Catalysis Letters 日期:2007 卷标:90(2) 页码:373-380]

2835-81-6 = 96-20-8
反应条件:1.1 Reagents: Hydrochloric Acid Catalysts: Calcium Acetate,Iron Oxide (Fe2O3) Solvents: Water; 10 H,3 Mpa,70 °C
标题:Catalytic Preparation Method Of Aminobutanol
参考文献:China]

609-31-4 = 96-20-8
反应条件:1.1 Reagents: Hydrogen Catalysts: Nickel Solvents: Methanol; 4 - 4.5 Mpa,Rt -> 70 °C
标题:Synthesis Of Racemic 2-Amino-Butanol With Microreactor
作者:Zang,Li; Yu,Rong-Hua; Qiao,Hao; Liu,Cun-Li
参考文献:Xiandai Huagong 日期:2015 卷标:35(9) 页码:125-127]

193086-15-6 = 96-20-8
反应条件:1.1 Reagents: Trifluoroacetic Acid Solvents: 1,4-Dioxane; Overnight,80 °C
标题:A Palladium-Catalyzed Protocol For The Synthesis Of 2-Phenyl-3-Tosyl-4-Vinyloxazolidine
作者:Chen,Chun-Chun; Kong,Li-Chun; Zhu,Gang-Guo
参考文献:Zhejiang Huagong 日期:2010 卷标:41(11) 页码:13-16]

609-31-4 = 96-20-8
反应条件:1.1 Reagents: Hydrogen Catalysts: Bis[chloro(Norbornadiene)Rhodium],1,1′-(1-Methyl-1,2-Ethanediyl)Bis[1,1-Diphenylphosphine] Solvents: Ethanol; 20 H,68 Atm,60 °C
标题:Bis(Bicyclo[2.2.1]Hepta-2,5-Diene)-Dichlorodirhodium
作者:Watanabe,Yoshihisa; Yorimitsu,Hideki; Oshima,Koichiro
参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2008 卷标:1 页码:1-4]

609-31-4 = 96-20-8 [标题:Reaction Conditions
标题:Reduction Of Nitro Alcohols Via Homogeneous Catalysis
参考文献:United States]

5339-83-3 = 96-20-8
反应条件:1.1 Reagents: Sodium Borohydride Solvents: Tetrahydrofuran; Rt1.2 Reagents: Iodine Solvents: Tetrahydrofuran; 1 H,0 °C; 4 H,67 °C; 67 °C -> 25 °C1.3 Reagents: Methanol; 25 °C1.4 Reagents: Potassium Hydroxide Solvents: Water; 3 H,Reflux
标题:New,Convenient Methods Of Synthesis And Resolution Of 1,2-Amino Alcohols
作者:Periasamy,Mariappan; Sivakumar,Sangarappan; Reddy,Meda Narsi
参考文献:Synthesis 日期:2003 卷标:(13) 页码:1965-1967

2-氨基-3-丁烯-1-醇反应生成 2-氨基-1-丁醇
参考文献:The Reaction Of Sodium Azide With Some Representative Epoxides
标题:The Reaction Of Sodium Azide With Some Representative Epoxides
摘要:
DOI:10.1021/ja01634A008