CAS: 10161-33-8; Trenbolone

该化合物是一种合成新陈代谢类固醇,主要用于兽医,以促进牲畜肌肉生长;在某些管辖区,由于可能发生虐待和健康风险,它被归类为附表三所列受控物质;特雷尼波隆表现出高度的亲和性和受体素,导致严重的新陈代谢效应,包括增加蛋白合成和氮保留,导致肌肉营养过大;众所周知,它对肌肉质量和体力有重大影响,尽管受到法律限制,但这种物质在身体锻炼者和运动员中很受欢迎;该物质通常通过注射施用,不被批准用于人类用途,因为它可导致各种副作用,包括心血管问题,荷尔蒙不平衡和心理影响;特雷尼波隆的化学结构允许它抗新陈代谢分解,导致体内长期行动;由于其威力和潜在不利影响,使用者必须了解使用该物质的法律和健康影响.

结构式图片

欧盟法规

REACH注册ECHA物质C&L通报REACH预注册

上下游产品

(8S,11R,13S,14S,17S)-11,17-Dihydroxy-13-methyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-cyclopenta[a]phenanthren-3-one 3-methoxy-estra-1,3,5(10)-triene-11α,17β-diol (8S,9S,11R,13S,14S,17S)-11,17-Dihydroxy-13-methyl-1,2,4,6,7,8,9,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one (8S,9S,11R,13S,14S,17S)-3-Methoxy-13-methyl-4,6,7,8,9,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-11,17-diol3,17-dioxoestra-4,9,11-triene Trendione trenbolone acetate

合成工艺路线路线简述

  • 合成目标产物 Trenbolone 主要起始原料 Estra-4,9-Dien-3-One, 11,17-Dihydroxy-, (11α,17β)- (9CI)
  • (文献来源)合成步骤主要原料 Estra-4,9-Dien-3-One, 11,17-Dihydroxy-, (11α,17β)- (9Ci)
3-缩酮置于钾硼氢,硫酸,2,3-二氯-5,6-二氰基-1,4-苯醌,正丁醇体系中,用 二氯甲烷,水,丙酮 用作溶剂,化学反应生成群勃龙
参考文献:一种制备群勃龙醋酸酯的方法
标题:一种制备群勃龙醋酸酯的方法
摘要:本发明公开了一种制备群勃龙醋酸酯的方法,属于激素类药物的制备加工技术领域.该方法以3‑亚乙二氧基雌甾‑δ 5,10,δ 9,11 ‑二烯‑17‑酮为起始原料,通过还原17位酮为醇,水解3位缩酮,氧化脱氢和17位醇乙酰化制备得到群勃龙醋酸酯.本发明所述的群勃龙醋酸酯合成工艺路线,原料价廉易得,反应控制简便副产物少,纯化容易,总产率高,在生产成本和可操作性上有极高的竞争力,适合工业化大规模生产,具有非常好的经济效益.

海关参考信息

专利信息


专利号:US-11078093-B2
优先权日:2017-06-30
标 题 :Surfactant-assisted synthesis of surface-functionalized nanoparticle-polymer electrospun composites
发明人:CWIERTNY DAVID; MYUNG NOSANG; PETER KATHERINE T; PARKIN GENE FRANCIS
权利人:UNIV CALIFORNIA; UNIV IOWA RES FOUND
摘要:A method is disclosed for synthesizing nanofilters for water treatment. The method includes: dispersing an active binding agent in an organic solvent solution to create a suspension of the active binding agent and the solution of the solvent; dissolving an organic polymer resin and an anionic surfactant in the suspension of the active binding agent and the solvent solution to create a sol gel; and electrospinning the sol gel to form electrospun nanofiber composites with embedded, surface-active nanoparticles.

专利号:WO-2005105153-A1
优先权日:2004-04-30
标 题 :Hydroxyalkyl derivatives of biologically active compounds
发明人:DESHPANDE JAYANT VENKATESH; KADAM VAISHALI MADHUKAR; GUPTE VANDANA SANDEEP; RANBHAN KAMLESH JAYANTILAL
权利人:KOPRAN RES LAB LTD; DESHPANDE JAYANT VENKATESH; KADAM VAISHALI MADHUKAR; GUPTE VANDANA SANDEEP; RANBHAN KAMLESH JAYANTILAL
摘要:Hydroxyalkyl derivatives of biologically active compounds represented by the formula VII wherein R2 = H, CI-12 alkyl, C6-12 aryl, or -OH and D = Biologically active agent having functional groups such as Formula (a) epoxy or aziridine and Z' = Formula (b) L= spacer comprising (un)substituted alkyl, hydroxyalkyl or alkoxy alkyl with the condition that the carbon chain length contains 2 to 6 carbon atoms when Z' = Formula (c) and pharmaceutically acceptable acid addition salts and enantiomers thereof Also process for the synthesis of compounds of the Formula VII and pharmaceutically acceptable acid addition salts and enantiomers thereof comprising condensation of the biologically active agents having functional groups such as Formula (d) epoxy or azifidine with substituted alkyl derivatives under alkaline conditions, at 20 - 80°C, in an organic solvent.

专利号:US-2014274978-A1
优先权日:2013-03-15
标题 :Phytosterol spirostane and spirostene derivatives having a wide variety of utilities in humans and other animals
发明人:FASCIOLA ANDRE ARMEL
权利人:FASCIOLA ANDRE ARMEL
摘要:The present invention utilizes phytosterol, phytoecdysteroid, sapogenin, triterpene, terpene, spirostane, spirostene and androstene derivative compounds to provide a wide variety of utilities to humans and other animals. The compounds and methods provide numerous and wide-ranging benefits including biochemical and constructive metabolic benefits including increases in protein synthesis and synthesis efficiency, ergogenic, adaptogenic, cosmetic and medicinal skin agents and veterinary utilities. The compounds provide agents that increase physical endurance and work output, act as a general tonic for increasing health and vigor, increase sleep time and sleep efficiency and act as rejuvenating agents to reverse the effects of fatigue and stress. Novel utilities for pet, farm, zoo and companion animals are also provided.

专利号:US-2019002309-A1
优先权日:2017-06-30
标 题 :Surfactant-assisted synthesis of surface-functionalized nanoparticle-polymer electrospun composites

专利号:US-8093415-B2
优先权日:2001-11-16
标题:Polyunsaturated fatty acid monovalent and divalent metal salt synthesis
发明人:LUCHINI DANIEL NESTOR; STROHMAIER GEORGE K; FREDERIKSEN EILER D; HAWKES JAMES G; DULL BOB J
权利人:LUCHINI DANIEL NESTOR; STROHMAIER GEORGE K; FREDERIKSEN EILER D; HAWKES JAMES G; DULL BOB J; VIRTUS NUTRITION LLC
摘要:Methods for the preparation of a free-flowing, storage-stable fatty acid metal salt product by forming a reactive admixture of (a) an unsaturated fatty acid glyceride feedstock; and (b) from about 1 mol to about 3 mol of at least one monovalent metal hydroxide or at least one divalent metal hydroxide; and heating the admixture to a temperature at which said fatty acid glycerides saponify to form fatty acid metals salts; wherein said monovalent metal is potassium; and wherein said divalent metal is selected from the group consisting of calcium, copper, magnesium and zinc. The fatty acid glycerides are saponified in an atmosphere in which the partial pressure of oxygen has been reduced by an amount effective to provide an improvement in storage stability until a free-flowing, storage-stage product is obtained. Storage stable metal salts of unsaturated fatty acids prepared by the inventive methods are also disclosed.

专利号:RU-2193566-C1
优先权日:2001-03-12
标题:Method of synthesis of succinic acid monoether from 17-hydroxysteroid and succinic anhydride
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参考文献:10.1007/s00216-010-3484-3
摘要:Peters RJB, Oosterink JE, Stolker AAM, Georgakopoulos C, Nielen MWF. Generic sample preparation combined with high-resolution liquid chromatography–time-of-flight mass spectrometry for unification of urine screening in doping-control laboratories. Analytical and Bioanalytical Chemistry. 2010 Feb 16;396(7):2583–98. doi: 10.1007/s00216-010-3484-3.
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