CAS: 104-83-6; 4-Chlorobenzyl Chloride

上下游产品

CAS号873-76-7 4-氯苄醇 | CAS号104-88-1 对氯苯甲醛 | CAS号3395-81-1 4-氯苯甲醛二甲基缩醛 | CAS号1878-66-6 4-氯苯乙酸 | CAS号106-43-4 对氯甲苯 | CAS号81067-97-2 4-chlorobenzyl ... | CAS号98181-84-1 1-chloro-4-(flu... | CAS号108-88-3 甲苯 | CAS号72825-24-2 2-imidazol-1-yl... | CAS号874-72-6 4-氯苄基氯化镁 | CAS号110577-61-2 2-[(4-chlorophe... | CAS号110577-60-1 tert-butyl 2-[(... | CAS号544-47-8 S-(4-氯苄基)异硫脲氯化铵 | CAS号3506-75-0 4-(4-氯苯基)-2-丁酮 | CAS号52031-05-7 2-氨基-3-(4-氯苯基)丙... | CAS号428482-55-7 5-Bromo-2-[(4-c... | CAS号38092-88-5 8-脱氯-9-氯-N-甲基地氯雷他定 | CAS号32327-71-2 3-(4-氯苯基)丙腈 | CAS号1875-88-3 4-氯苯乙醇 | CAS号106-43-4 对氯甲苯

4-氯苯甲醇置于1-Methylsulfinyl-2-Methoxybenzene,苯甲酰氯体系中,用 乙腈 用作溶剂,化学反应 18.0H,以81%的收率获得4-氯氯苄
参考文献:系统评价亚砜作为亲核取代醇中的催化剂
标题:系统评价亚砜作为亲核取代醇中的催化剂
摘要:在深入研究一系列亚砜基化合物将醇转化为氯代烷烃的过程中,出现了(2-甲氧基苯基)甲基亚砜作为最佳的路易斯碱催化剂.尽管该催化剂可以合成多达50个转换量的苄基氯,但由于竞争的pummerer重排,脂肪族醇不适合作为底物.
Doi:10.1002/ejoc.201800907

专利信息

专利号:US-8350031-B2
优先权日:2008-06-02
标 题:Processes for the synthesis of levocetirizine and intermediates for use therein
发明人：RAO DHARMARAJ RAMACHANDRA; KANKAN RAJENDRA NARAYANRAO; GHAGARE MARUTI; CHIKHALIKAR SANDIP VASANT
权利人:CIPLA LTD; RAO DHARMARAJ RAMACHANDRA; KANKAN RAJENDRA NARAYANRAO; GHAGARE MARUTI; CHIKHALIKAR SANDIP VASANT
摘要:The present invention provides a compound of formula (IV) n nwherein R is Cl, Br, NO 2 , OH or OR′, and R′ is alkyl, and its use in the synthesis of levocetirizine, including its use in the synthesis of (−)-1-[(4-chlorophenyl)-phenylmethyl]piperazine, an intermediate useful in the synthesis of levocetirizine. The present invention also provides compounds (II) and (III) which are useful in the synthesis of compound (IV).

专利号:US-2004058888-A1
优先权日:2000-01-13
标题:Methods for synthesis of alpha-d-gal (1~>3) gal-containing oligosaccharides
发明人：BORNAGHI LAURENT; DEKANY GYULA; DRINNAN NICHOLAS BARRY; PAPAGEORGIOU JOHN; WEST MICHAEL LEO
摘要:This invention relates to reagents and methods for synthesis of biologically active di- and tri-saccharides comprising α-D-Gal(1→3)-D-Gal. In particular the invention provides novel reagents, intermediates and processes for the solution or solid phase synthesis of α-D-galactopyranosyl-(1→3)-D-galactose, and derivatives thereof. In one preferred embodiments the invention provides a protected monosaccharide building block of general formula (II): in which R 3 is methoxy or methyl; R 1 is H, benzoyl, pivaloyl, 4-chlorobenzoyl, acetyl, chloroacetyl, levulinoyl, 4-methylbenzoyl, benzyl, 3,4-methylenedioxybenzyl, 4-methoxybenzyl, 4-chlorobenzyl, 4-acetamidobenzyl, or 4-azidobenzyl; and R 2 is H, Fmoc, benzoyl, pivaloyl, 4-chlorobenzoyl, acetyl, chloroacetyl, levulinoyl, 4-methylbenzoyl, benzyl, 3,4-methylenedioxybenzyl, 4-methoxybenzyl, 4 -chlorobenzyl, 4-acetamidobenzyl, or 4-azidobenzyl.

专利号:US-7102023-B2
优先权日:1999-11-24
标 题:Protecting groups useful in the synthesis of polysaccharides, natural products, and combinatorial libraries
发明人：BUCHWALD STEPHEN L; PLANTE OBADIAH J; SEEBERGER PETER H
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:One aspect of the present invention relates to optionally substituted halogenated benzyl halides and the like. These compounds are useful as halogenated benzyl ether-based protecting groups for a variety of functional groups. Another aspect of the present invention relates to use of said protecting groups in an orthogonal protecting group strategy for the synthesis of complex molecules that comprise a number of suitable functional groups. Another aspect of the present invention relates to saccharides bearing various arrays of protecting groups of the present invention. Another aspect of the present invention relates to a method of synthesizing an oligosaccharide or glycoconjugate, comprising the steps of: using a saccharide bearing at least one protecting group of the present invention to glycosylate a second molecule to give a product comprising said saccharide; and removing a protecting group of the present invention from said product.

专利号:EP-0791575-A1
优先权日:1996-02-16
标题 :Method of synthesis of a quaternary ammonium salt
发明人：NAKANO SHINJI
权利人:NIPPON PAINT CO LTD
摘要:The present invention provides an improved method of synthesis of a quaternary ammonium salt in which a tertiary amine is reacted with a benzyl halide optionally having on the benzene ring and/or at the α-site one ore more substituent groups inert to the reaction, which method is characterized in that the reaction is carried out in water or in a water-containing organic solvent.

专利号:US-6608202-B1
优先权日:2001-08-21
标题:Process of synthesis of a tricyclic ketone intermediate
发明人：DORAN HENRY J; O'NEILL PAT M; WILLIAMS ROBERT P
权利人:SCHERING CORP
摘要:In one embodiment, the present invention describes the synthesis of a compound of Formula III, wherein X is halogen,and intermediates therefor from easily available starting materials by a simple route.

专利号:US-7189864-B2
优先权日:1990-11-19
标 题:Method of preparing intermediates useful in synthesis of retroviral protease inhibitors
发明人：NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P
权利人:SEARLE & CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.