CAS: 104142-93-0; Norfloxacin Hydrochloride(1:X)

该化合物是一种主要用于治疗细菌感染,特别是影响尿道和胃肠系统感染的合成的氟己酮抗生素,其特征是,它针对克己体和克己体阴性细菌的广谱活动,抑制细菌DNA甘蓝和四氯化萘,这是DNA复制和转录所必不可少的;该化合物通常以白色为白,在水和甲醇中可溶解,熔点相对较低;诺氟辛盐经常通过口服,并因其有利的药用皮肤特性而闻名,包括良好的生物利用率;然而,它与其他氟丙酮一样,可能与副作用有关,如胃肠紊乱,中...

英文名称Norfloxacin Hydrochloride(1:X)
中文名称氟哌酸盐酸盐
IUPAC名称1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride
其它别名1-Ethyl-6-Fluoro-1,4-Dihydro-4-Oxo-7-(1-Piperazinyl)-3-Quinolinecarboxylic Acid Hydrochloride; Norfloxacin Hydrochloride; Norfloxacin Hydrochloride (1:X); 3-Quinolinecarboxylicacid, 1-Ethyl-6-Fluoro-1,4-Dihydro-4-Oxo-7-(1-Piperazinyl)-, Hydrochloride(1:); Norfloxacin Hydrochloride For Injection; Hydrochloric Acid Norfloxacin; 1-Ethyl-6-Fluoro-4-Oxo-7-Piperazin-1-Ylquinoline-3-Carboxylic Acid,Hydrochloride; Nofloxacin Hydrochloride
CAS编号104142-93-0
MFCD编号:MFCD01075766
FDA UNII编号:7O3ULA741Z
分子式:C16H19ClFN3O3
分子量:355.8
产品CID: 79556
产品分类原料药 → 抗生素类药物 → 其它抗生素类药

相似结构搜索
InChIKey: JJWDELPVPRCLQN-UHFFFAOYSA-N
InChI=1S/C16H18FN3O3.ClH/c1-2-19-9-11(16(22)23)15(21)10-7-12(17)14(8-13(10)19)20-5-3-18-4-6-20;/h7-9,18H,2-6H2,1H3,(H,22,23);1H…
计算化学: 氢键受体数7.0氢键供体数3.0可旋转键数3.0

物理性质

熔点220 °C
沸点573.8 °C at 760 mmHg
闪点300.8 °C
PSA:74.57
LogP:2.4641
蒸汽压5.26E-14mmHg at 25°C
溶解性insoluble in EtOH; ≥27.3 mg/mL in H2O; ≥5.05 mg/mL in DMSO with gentle warming
产品应用氟哌酸盐酸盐(104142-93-0)的用途:本品为氟喹诺酮类抗菌药,用于治疗畜禽细菌及支原体感染;注射或饮水剂.

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H315-H320-H335
防范说明P261-P280-P301+P312-P302+P352-P305+P351+P338
安全声明H303+H313+H333

上下游产品

piperazine 7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 1-ethyl-6-fluoro-7-chloro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester ethyl 7-chloro-6-fluoro-4-oxo-1,4-dihydroquinoline 3-carboxylate1-ethyl-6-fluoro-4-oxo-7-(4-(N-(phenylsulfonyl)carbamimidoyl)piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid 1-ethyl-6-fluoro-4-oxo-7-(4-(N-tosylcarbamimidoyl)piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid 7-(4-(N-(4-chlorophenylsulfonyl)carbamimidoyl)piperazin-1-yl)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 1-ethyl-6-fluoro-4-oxo-7-(4-(N-(4-(trifluoromethyl)phenylsulfonyl)carbamimidoyl)piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid

合成工艺路线路线简述

海关参考信息

2905199090-其他饱和一元醇
2905399099-其他二元醇
2905499000-其他多元醇
2905590090-其他无环醇的卤化、磺化等衍生物
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:CN-114797906-A
优先权日:2021-01-27
标题:A kind of in situ synthesis method of BiOCl@Bi2S3 composite and its application

专利号:CN-1158846-A
优先权日:1995-05-09
标题 :Synthesis technology of norfluxacini hydrochloride

其他信息查阅

江西忠鸣医药原料有限公司

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企业联系电话：0795-7855788;0795-7855222;13506766662;15257615528👤
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合成参考文献

参考文献:10.1007/7081_2023_65
摘要:Strunk K, Reiser O. Heterocycles from Cyclopropanation of Five-Membered Heteroarenes. 2023. In: Topics in Heterocyclic Chemistry.
参考文献:10.1134/s0036023623602386
摘要:Turyshev ES, Kubasov AS, Golubev AV, Zhizhin KY, Kuznetsov NT. Potentiometric Method for Determining Biologically Non-Degradable Antimicrobial Substances. Russ. J. Inorg. Chem. 2023 Dec;68(12):1841–7. doi: 10.1134/s0036023623602386.
参考文献:10.1134/s1990747823070024
摘要:Chistyulin DK, Zelepuga EA, Novikov VL, Balaneva NN, Glazunov VP, Chingizova EA, Khomenko VA, Novikova OD. Molecular Model of Norfloxacin Translocation through Yersinia pseudotuberculosis Porin OmpF Channel: Electrophysiological and Molecular Modeling Study. Biochem. Moscow Suppl. Ser. A. 2023 Dec;17(S1):S20–38. doi: 10.1134/s1990747823070024.
参考文献:10.1007/s11164-025-05589-2
摘要:Zhang M, Huang C, He C, Zhang X, Zheng J, Lin L. Ratiometric fluorescence sensing of besifloxacin based on oxygen-doped g-C3N4-MOF composite interface. Res Chem Intermed. 2025 Apr 22;51(6):3425–37. doi: 10.1007/s11164-025-05589-2.
参考文献:10.1007/s10854-025-15795-8
摘要:Huang X, Xin B, Ma H, Wang Y, Sun Y, Wang D, Li J, Zhang M, Guo J. Hydroxylamine enhanced FeOOH-mediated advanced oxidation processes for the treatment of norfloxacin. J Mater Sci: Mater Electron. 2025 Sep;36(26). doi: 10.1007/s10854-025-15795-8.