CAS: 107-43-7; 2-(Trimethylammonio)Acetate

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(R)-1-Hydroxy-2-(Trimethylammonio)Ethylphosphonate置于leisingera Caerulea Tmpb Oxygenase,氧气,Sodium Ascorbate体系中,用 Aq. Buffer 用作溶剂,化学反应 4.0H,反应生成甜菜碱
参考文献:由两种先前错误注释的非血红素铁加氧酶催化有机膦酸盐降解的新微生物途径.
标题:由两种先前错误注释的非血红素铁加氧酶催化有机膦酸盐降解的新微生物途径.
摘要:假设蛋白质的生化功能分配受到许多蛋白质结构超家族功能多样化的挑战.这种多样化对于金属酶来说尤其常见,使得仅基于序列和结构域相似性的功能注释变得不可靠并且常常是错误的.确定这些超家族内功能亚群的生化表征将有助于改进功能注释的生物信息学方法.我们在此描述了两种非血红素铁加氧酶 Tmpa 和 Tmpb 的结构和功能特征,这两种酶由在 350 多种细菌中发现的一对基因组簇基因编码.Tmpa 和 Tmpb 是一对酶(phny 和 Phnz)的功能同系物,可降解 2-氨基乙基膦酸酯,但作用于其天然存在的季铵类似物 2-(三甲基铵)乙基膦酸酯 (Tmaep).Tmpa 是一种铁 (II) 和 2-(氧代) 戊二酸依赖性加氧酶,被误认为是 γ-丁甜菜碱 (γbb) 羟化酶,对 γbb 没有活性,但能有效羟化 Tmaep.然后,产物(R)-1-羟基-2-(三甲基铵基)乙基膦酸酯[(R)-Oh-Tmaep]充
Doi:10.1021/acs.Biochem.9B00044

专利信息

专利号:US-7344863-B2
优先权日:1998-03-13
标题:Methods for producing polypeptides through enhanced synthesis of encoding nucleic acid molecules
发明人：LI WU-BO; JESSEE JOEL A; SCHUSTER DAVID; XIA JIULIN; GEBEYEHU GULILAT
权利人:INVITROGEN CORP
摘要:The present invention is directed to compositions and methods for enhancing synthesis of nucleic acid molecules, particularly GC-rich nucleic acid molecules. Specifically, the invention provides compositions comprising one or more nitrogen-containing organic compounds having a formula selected from the group consisting of formula I and formula II (or salts or derivatives thereof), preferably 4-methylmorpholine N-oxide or betaine (carboxymethyltrimethylammonium), and further comprising one or more compounds selected from the group consisting of proline and an N-alkylimidazole compound, and more preferably proline, 1-methylimidazole or 4-methylimidazole. The invention further relates to methods for enhanced, high-fidelity synthesis of nucleic acid molecules, including via amplification (particularly PCR), reverse transcription, and sequencing methods. The invention also relates to nucleic acid molecules synthesized by these methods, to fragments or derivatives thereof, and to vectors and host cells comprising such nucleic acid molecules, fragments, or derivatives. The invention also relates to kits for synthesizing, amplifying, reverse transcribing or sequencing nucleic acid molecules comprising one or more of the compositions of the invention.

专利号:US-5684191-A
优先权日:1996-10-31
标 题 :Process for the combined synthesis of betaine and choline chloride
发明人：BELLIS HAROLD EDWARD; JEMISON THOMAS ROBERT; MATHRE OWEN B
权利人:DUCOA LP
摘要:A process for the combined synthesis of betaine and choline chloride from monochloroacetic acid, trimethylamine and ethylene oxide by first reacting trimethylamine with monochloroacetic acid, and then reacting ethylene oxide with the reaction product from the previous step.

专利号:US-9005920-B2
优先权日:2009-06-15
标 题 :Solution for cell-free protein synthesis, kit for cell-free protein synthesis, and method of protein synthesis
发明人：KUSUMEGI TAKAHIRO; KAWAGUCHI TOSHIYA
权利人:KUSUMEGI TAKAHIRO; KAWAGUCHI TOSHIYA; TOYOTA MOTOR CO LTD
摘要:This invention enables synthesis of proteins that were difficult to synthesize via a conventional cell-free protein synthesis system and increases the amount of proteins synthesized. Cell-free protein synthesis is carried out in a solution for cell-free protein synthesis containing a certain compound, such as trimethylglycine, L-carnitine, or sarcosine.

专利号:US-2015376219-A1
优先权日:2014-06-30
标题 :Selective Preparations of Purine Nucleosides and Nucleotides: Reagents and Methods
发明人：ZHONG MINGHONG
权利人:ZHONG MINGHONG
摘要:A process of regiospecific synthesis of N-9 purine nucleoside analogs in either solution or solid phase synthesis is described. The introduction of the sugar moiety or its analogue on to a 6-heteroarylium purine or its mesomeric betaine so that formation of only the N-9 position regioisomers of the purine nucleoside analogs (either D or L enantiomers) is obtained. This regiospecific introduction of the sugar moiety allows the synthesis of purine nucleoside analogs in high yields without formation of the N-7-positional regioisomers, while the 6-heteroaryliums are leaving groups facilitated for nucleophilic displacement. Solid supported 6-heterarylium purine bases can be used for purine based library synthesis and synthesis of nucleotide monophosphates and polyphosphates. Processes for providing novel 6-heteroarylium purines and their corresponding mesomeric betaines for the regiospecific synthesis of N-9 purine nucleoside analogs and nucleotides are described.

专利号:US-7384739-B2
优先权日:2001-11-14
标题 :Compositions for enhancing DNA synthesis, DNA polymerase-related factors and utilization thereof
发明人：KITABAYASHI MASAO; KUROITA TOSHIHIRO; ISHIDA YOSHIKAZU; KOMATSUBARA HIDEYUKI; NISHIYA YOSHIAKI; OKA MASANORI; KAWAMURA YOSHIHISA; IMANAKA TADAYUKI
权利人:TOYO BOSEKI
摘要:The invention provides methods, kits, and compositions for enhancing synthesis of DNA involving a carboxylate ion-supplying substance that is effective in promoting DNA synthesis in enzymatic DNA synthesis reactions. The invention further provides a thermostable DNA polymerase-related factor derived from Thermococcus species, which has an activity to promote the DNA synthesis activity of DNA polymerase or which binds to DNA polymerase.

专利号:WO-2024153643-A1
优先权日:2023-01-16
标 题 :Inkjet-assisted enzymatic nucleic acid synthesis
发明人：MOGHADDAM NICOLAS; ADELIZZI BEATRICE; LOMAN TESSA; VERARDO DAMIANO; RODRIGUEZ-PINZON DANIEL; HORGAN ADRIAN
权利人:DNA SCRIPT
摘要:Methods, devices, and compositions are provided for inkjet-assisted synthesis of a plurality of polynucleotides at reaction sites on a substrate using template-free polymerases, such as, terminal deoxynucleotidyl transferases (TdTs). Compositions include printable stabile formulations of synthesis reagents for inkjet delivery including, but not limited to, template-free polymerases, divalent cations, and nucleotides.