CAS: 112204-58-7; 5-Bromo-2-Fluorophenol

相似化合物

156682-53-0 355423-48-2 221220-99-1

上下游产品

CAS号112204-57-6 5-溴-2-氟苯硼酸 | CAS号460-00-4 对氟溴苯 | CAS号103291-07-2 2-氟-5-溴苯甲醚 | CAS号348-61-8 3,4-二氟溴苯 | CAS号112204-59-8 4-bromo-1-fluor... | CAS号954235-78-0 5-溴-2-氟-1-二氟甲氧基苯 | CAS号103291-07-2 2-氟-5-溴苯甲醚 | CAS号900174-64-3 4-溴-2-乙氧基-1-氟苯 | CAS号944278-95-9 4-溴-1-氟-2-异丙氧基苯

对溴氟苯置于正丁基锂,硼酸三甲酯,双氧水体系中,用 四氢呋喃 用作溶剂,化学反应 6.5H,以90%的收率获得5-溴-2-氟苯酚
参考文献:1-苄氧基-4-溴-5-乙基-2-氟苯的制备方法
标题:1-苄氧基-4-溴-5-乙基-2-氟苯的制备方法
摘要:本发明为有机合成技术领域,具体涉及了一种1‑苄氧基‑4‑溴‑5‑乙基‑2‑氟苯的合成,以对溴氟苯为原料,首先在丁基锂碱性条件下跟硼酸三甲酯反应,然后水解得到式(1)化合物,式(1)化合物在碱性条件下跟溴苄反得到式(2)化合物;式(2)化合物在镍络合物催化剂作用下跟乙基氯化镁反应得到式(3)化合物;式(3)化合物跟溴化铜反应得到目标式(4)化合物.本发明为医药中间体1‑苄氧基‑4‑溴‑5‑乙基‑2‑氟苯的合成提供一个简便的工业化生产路线,优点在于避免了昂贵的锌试剂和钯络合物催化剂,反应操作简单,成本较低.

专利信息

专利号:US-10040752-B2
优先权日:2015-08-24
标 题 :Synthesis of levomethadone hydrochloride or dextromethadone hydrochloride and methods for use thereof
发明人：MKRTCHYAN GNEL; YAO QINGWEI
权利人:CODY LABORATORIES INC
摘要:Highly efficient methods for synthesis of levomethadone hydrochloride or dextromethadone hydrochloride are provided starting from D-alanine, or L-alanine, respectively, with retention of configuration. Methods for treating a subject are provided comprising administering a composition comprising an effective amount of levomethadone hydrochloride having not more than 10 ppm dextromethadone.

专利号:US-6828466-B2
优先权日:2002-07-19
标题:Process for the synthesis of phenols from arenes
发明人：MALECZKA JR ROBERT E; SMITH III MILTON R; HOLMES DANIEL; SHI FENG
权利人:UNIV MICHIGAN STATE
摘要:A process to synthesize substituted phenols such as those of the general formula RR'R''Ar(OH) wherein R, R', and R'' are each independently hydrogen or any group which does not interfere in the process for synthesizing the substituted phenol including, but not limited to, halo, alkyl, alkoxy, carboxylic ester, amine, amide; and Ar is any variety of aryl or hetroaryl by means of oxidation of substituted arylboronic esters is described. In particular, a metal-catalyzed C-H activation/borylation reaction is described, which when followed by direct oxidation in a single or separate reaction vessel affords phenols without the need for any intermediate manipulations. More particularly, a process wherein Ir-catalyzed borylation of arenes using pinacolborane (HBPin) followed by oxidation of the intermediate arylboronic ester by OXONE is described.

专利号:US-2019002394-A1
优先权日:2015-08-24
标 题 :Synthesis of levomethadone hydrochloride or dextromethadone hydrochloride and methods for use thereof

专利号:US-7582633-B2
优先权日:2007-01-26
标题:Azacycloalkane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：LEBLANC YVES; POWELL DAVID; RAMTOHUL YEEMAN K; LEGER SERGE
权利人:MERCK FROSST CANADA L L C
摘要:Azacycloalkane derivatives of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.

专利号:US-2004030197-A1
优先权日:2002-07-19
标 题 :Process for the synthesis of phenols from arenes

专利号:US-2017057909-A1
优先权日:2015-08-24
标 题 :Synthesis of levomethadone hydrochloride or dextromethadone hydrochloride and methods for use thereof