CAS: 13614-98-7; Minocycline (Hydrochloride)

相似化合物

149934-21-4 43168-51-0 4708-96-7

上下游产品

O-benzoyl N,N-dimethylhydroxylamine sancycline MIN°CYCLINE formaldehyd9-(N,N-dimethylglycylamido)-min°Cycline [4S-(4a,12aα)]-12-amino-4,7-bis(dimethylamino)-3,10,12a-trihydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-°Ctahydro-naphthacene-2-carboxylic acid amide (4S,4aS,5aR,12S)-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-°Ctahydro-3,10,12,12a-tetrahydroxy-9-nitro-1,11-dioxanaphthacene-2-carboxamide 24H29N3O8C24H29N3O8

山环素置于iron(III) Chloride,三乙胺体系中,用 二氯甲烷,甲苯 用作溶剂,化学反应 3.5H,反应生成盐酸米诺环素
参考文献:一种米诺环素的制备方法
标题:一种米诺环素的制备方法
摘要:本发明公开了一种米诺环素的制备方法,所述米诺环素为(4S,4As,5Ar,12As)‑4,7‑双二甲胺基‑3,10,12,12A‑四羟基‑1,11‑二氧代‑1,4,4A,5,5A,6,11,12A‑八氢并四苯‑2‑甲酰胺,由sancycline山环素经酰基保护酚羟基后选择性二甲氨基化6‑位.本工艺路线采取保护策略后,避免了9‑位二甲氨基化副产物的生成,纯化简单.反应中避免使用贵金属,生产单元操作简单,安全环保,十分适合工业化生产.

专利信息

专利号:WO-2009056955-A1
优先权日:2007-10-30
标题 :Amine-bearing phospholipids (abps), their synthesis and use
发明人：ZUMBUEHL ANDREAS
权利人:UNIV BASEL; ZUMBUEHL ANDREAS
摘要:Disclosed herein are amine-bearing phospholipids (ABP). The ABPs display many properties and functionalities of naturally occurring phospholipids, but also new properties and functionalities, such as the ability to polymerize while maintaining structural integrity, that may supplement or expand the functionalities of naturally occurring phospholipids.

专利号:US-11213532-B2
优先权日:2018-06-27
标 题 :Therapy and prevention of prion protein complex infections in non-human animals
发明人：ATIBA JOSHUA O; SEREBOFF STEVEN C
权利人:ATIBA JOSHUA O; SEREBOFF STEVEN C
摘要:There are disclosed therapies and preventions of prion protein complex infections. The transcription of the amyloid precursor protein gene and PrP gene and the RNA transcript are the rate-limiting steps and are most susceptible for blockage and control of the process of amyloid protein formation and PrPsc formation. Thus, therapies and prevention regimes for prion protein complex infections interrupt this process at the level of DNA transcription to RNA, RNA transport to the mitochondrion for protein synthesis and deposition in the cerebral cortex neurons.

专利号:DE-102007034259-A1
优先权日:2007-07-20
标 题:Process for the synthesis of A-ring-flavored acetyl-minocycline

专利号:EP-2178825-B1
优先权日:2007-07-20
标 题 :Method for the synthesis of a-ring aromatized acetyl minocyclines
发明人：LORENZ PETER; KREUTZMANN PETER; ROTHE FRITZ; MARTENS-LOBENHOFFER JENS; SCHMIDT HARRY; WOLF GERALD
权利人:OTTO VON GUERICKE UNIVERSITÄT MAGDEBURG MEDIZINISCHE FAKULTÄT

专利号:EP-2178825-A1
优先权日:2007-07-20
标题:Method for the synthesis of a-ring aromatized acetyl minocyclines

专利号:CN-114685302-A
优先权日:2022-02-17
标 题 :A method for the continuous synthesis of 9-aminominocycline in a microreactor