CAS: 15118-60-2; 4-(4-Aminophenyl)Butanoic Acid

相似化合物

186320-14-9 5600-62-4 20637-09-6

上下游产品

CAS号5600-62-4 4-(4-硝基苯基)丁酸 | CAS号1821-12-1 4-苯基丁酸 | CAS号15116-32-2 4-(4-氨基苯)丁酸乙酯 | CAS号5600-62-4 4-(4-硝基苯基)丁酸 | CAS号20637-09-6 4-(对氨基苯)丁酸甲酯 | CAS号100072-54-6 4-N-MALEIMIDOPH... | CAS号103489-33-4 4-(4-叠氮基苯基)丁酸 | CAS号105300-90-1 4-(4-((叔丁氧基羰基)氨... | CAS号186320-14-9 4-(4-((((9H-芴-9... | CAS号15116-32-2 4-(4-氨基苯)丁酸乙酯 | CAS号91251-45-5 4-(4-aminopheny...

3-(4-乙酰基氨基苯甲酰基)丙酸置于一水合肼,Potassium Hydroxide体系中,用 二乙二醇 用作溶剂,化学反应 8.0H,反应生成4-(4-氨基苯基)丁酸
参考文献:新型enmein型二萜类杂化物与氮芥末结合:有望用于抗癌治疗药物的合成.
标题:新型enmein型二萜类杂化物与氮芥末结合:有望用于抗癌治疗药物的合成.
摘要:天然来源的半球蛋白型二萜类化合物对多种人类癌细胞具有细胞毒性.然而,它们的医学应用受到化学疗法效力不足的阻碍.因此,设计并合成了一系列新型的烯醇式二萜类杂种与氮芥类,以增加抗肿瘤功效,同时降低全身毒性.大多数缀合物比亲本二萜和氮芥具有更强的抗增殖活性,特别是对于具有多重耐药性的肿瘤细胞系bel-7402 / 5-Fu.其中,化合物e2在人白血病hl-60细胞,人前列腺癌pc-3细胞,人肝癌bel-7402细胞和耐药性人肝癌bel-7402 / 5-Fu细胞中表现出最强的抑制活性. Ic50值分别为7.83μm,3.97μm,0.77μm和2.07μm.另外,还从l-02人正常肝细胞和bel-7402恶性肝细胞之间的细胞毒性评估中观测到选择性指数超过130的高选择性.作用机理的进一步研究表明,E2诱导bel-7402肝癌细胞凋亡和g1期细胞周期停滞.此外,线粒体途径的功能障碍也与e2启动的细
Doi:10.1016/j.Ejmech.2018.01.069

专利信息

专利号:US-9206222-B2
优先权日:2009-06-29
标题:Solid phase peptide synthesis of peptide alcohols
发明人：CAUSSIL-AMBLARD MURIEL; MARTINEZ JEAN; TAILHADES JULIEN
权利人:CAUSSIL-AMBLARD MURIEL; MARTINEZ JEAN; TAILHADES JULIEN; CENTRE NAT RECH SCIENT
摘要:The present invention relates to the synthesis of depsipeptides on solid phase support. Said depsipeptides are then implicated in a solution phase O—N acyl shift enabling to obtain the corresponding peptide alcohols.

专利号:US-5783577-A
优先权日:1995-09-15
标题 :Synthesis of quinazolinone libraries and derivatives thereof
发明人：HOUGHTEN RICHARD A; OSTRESH JOHN M
权利人:TREGA BIOSCIENCES INC
摘要:The present invention provides synthetic combinatorial libraries of organic compounds based on the quinazolinone ring.

专利号:WO-9710221-A1
优先权日:1995-09-15
标 题:Synthesis of quinazolinone libraries
发明人：HOUGHTEN RICHARD A; OSTRESH JOHN M
权利人:TORREY PINES INST
摘要:The present invention provides synthetic combinatorial libraries of organic compounds based on the quinazolinone ring.

专利号:WO-2013114173-A1
优先权日:2012-01-30
标题:A novel process for the preparation of sitagliptin
发明人：MALLELA SAMBHU PRASAD SARMA; HAVALE SHRIKANT HANUMANTAPPA; BODDEPALLI NAGABHUSHANA RAO; GUNJI NAGARJUNA; MOKKAPATI BHAVANI SANKAR
权利人:SMILAX LAB LTD; MALLELA SAMBHU PRASAD SARMA; HAVALE SHRIKANT HANUMANTAPPA; BODDEPALLI NAGABHUSHANA RAO; GUNJI NAGARJUNA; MOKKAPATI BHAVANI SANKAR
摘要:The present invention is directed to a process for the preparation of enantiomerically enriched β-amino acid derivatives which are important chiral building blocks and intermediates in pharmaceuticals. More specifically, the invention pertains to a novel process for practically convenient and economically producing enantiomerically enriched β-amino acid derivatives which are useful for the synthesis of amide inhibitors of dipeptidyl peptidase IV like Sitagliptin, which have been used to treat type 2 diabetes.

专利号:US-8546533-B2
优先权日:2008-08-29
标 题:Pipecolic linker and its use for chemistry on solid support
发明人：MARTINEZ JEAN; ZAJDEL PAWEL; PAWLOWSKI MACIEJ; SUBRA GILLES
权利人:MARTINEZ JEAN; ZAJDEL PAWEL; PAWLOWSKI MACIEJ; SUBRA GILLES; CENTRE NAT RECH SCIENT; UNIV MONTPELLIER 1; UNIV JAGELLONE; UNIV MONTPELLIER II
摘要:The present invention relates to a pipecolic linker and its use as a solid-phase linker in organic synthesis. Said pipecolic solid-phase linker may be used for coupling functional groups chosen between primary amines, secondary amines, aromatic amines, alcohols, phenols and thiols. In particular, said pipecolic solid-phase linker may be used for peptide or pseudopeptide synthesis, such as the reverse N to C peptide synthesis or the retro-inverso peptide synthesis, or for the synthesis of small organic molecules.

专利号:WO-2011000848-A1
优先权日:2009-06-29
标题 :Solid phase peptide synthesis of peptide alcohols