CAS: 16533-71-4; 4-Methyl-3,5-Dinitrobenzoic Acid

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4-甲基-3-硝基苯甲酸置于硫酸,硝酸体系中,用 水 用作溶剂,化学反应生成3,5-二硝基-4-甲基苯甲酸
参考文献: Fluoro-Substituted Compounds As Kinase Inhibitors And Methods Of Use Thereof[fr] Composés à Substitution Fluoro En Tant Qu'Inhibiteurs De Kinase Et Leurs Méthodes D'Utilisation
标题: Fluoro-Substituted Compounds As Kinase Inhibitors And Methods Of Use Thereof[fr] Composés à Substitution Fluoro En Tant Qu'Inhibiteurs De Kinase Et Leurs Méthodes D'Utilisation
摘要:本发明提供了具有激酶抑制活性的formula I的新化合物及其药用可接受的盐和溶剂化合物.本发明还提供了包含相同化合物的药物组合物,以及治疗和预防bcr-Abl,C-Kit或pdgf-R介导的疾病的方法,其中一个或多个激酶抑制剂被指示,包括肿瘤病,如慢性髓细胞白血病或胃肠道间质瘤.本发明还提供了制备formula I化合物的方法,包括其盐和溶剂化合物,以及包含相同化合物的药物组合物的过程.

专利信息

专利号:US-8932384-B1
优先权日:2011-04-04
标 题 :Surface enhanced raman spectroscopy gold nanorods substrates for detection of 2,4,6-trinitrotoulene and 3,5-dinitro-4-methylbenzoic acid explosives
发明人：HERNANDEZ-RIVERA SAMUEL P; PRIMERA-PEDROZO OLIVA M; CHAMOUN-EMANUELLI ANA M; MEDINA-RAMOS WILMARIE
权利人:HERNANDEZ-RIVERA SAMUEL P; PRIMERA-PEDROZO OLIVA M; CHAMOUN-EMANUELLI ANA M; MEDINA-RAMOS WILMARIE; UNIV PUERTO RICO
摘要:The invention described relates to the synthesis of gold nanorods in high concentrations in a single batch and their use in detection of nitroexplosives using Surface Enhanced Raman Spectroscopy (SERS). The nanoparticle suspensions were stable up to a month after preparation. The aggregated nanorods have a strong SERS effect for nitroexplosives (3,5-dintro-4-methylbenzoic acid and 2,4,6-TNT) with sensitivity of 5.0 pg in a few seconds. The results obtained in numerous tests demonstrated a high reproducibility that makes aggregated nanorods very attractive substrates for defense and security applications.

专利号:US-9217012-B2
优先权日:2009-04-08
标题 :Inhibitors of protein tyrosine phosphatases
发明人：ZHANG ZHONG-YIN; ZHANG SHENG
权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.

专利号:CN-109912423-B
优先权日:2019-04-24
标 题 :A kind of green synthesis process of 3,5-dinitro-4-methylbenzoic acid

专利号:CN-109912423-A
优先权日:2019-04-24
标 题:A kind of green synthesis process of 3,5- dinitro -4- methyl benzoic acid