CAS: 38212-30-5; 1-(4-Methoxyphenyl)Piperazine

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CAS号821-48-7 二(2-氯乙基)胺盐酸盐 | CAS号104-94-9 对甲氧基苯胺 | CAS号110-85-0 哌嗪 | CAS号104-92-7 对溴苯甲醚 | CAS号623-12-1 4-氯苯甲醚 | CAS号696-62-8 4-碘苯甲醚 | CAS号159974-38-6 3-(2-((4-methox... | CAS号38869-37-3 1-(4-羟苯基)哌嗪二氰溴化物 | CAS号40255-50-3 3-[4-(4-甲氧基苯基)-... | CAS号20529-26-4 2-(4-(4-甲氧基苯基)哌... | CAS号89848-21-5 诺孕烯酮 | CAS号74853-07-9 4-(4-(4-(4-甲氧基苯... | CAS号74853-08-0 1-(4-氨基苯基)-4-(4... | CAS号74852-62-3 4-(4-(4-甲氧基苯基)-... | CAS号67914-60-7 酮康唑侧链 | CAS号56621-48-8 1-对羟基苯基哌嗪 | CAS号74852-89-4 Hydrazine Carbo...

Tert-Butyl 4-(4-Methoxyphenyl)Piperazine-1-Carboxylate置于盐酸体系中,用 1,4-二氧六环 用作溶剂,化学反应生成1-(4-甲氧基苯基)哌嗪
参考文献:新型glut抑制剂的鉴定
标题:新型glut抑制剂的鉴定
摘要:使用hts将1 H-吡唑并[3,4-D ]嘧啶类化合物鉴定为促进葡萄糖转运蛋白1(glut1)的非常有效的抑制剂.建立了分子框架每个环系统的广泛结构-活性关系研究(sar),揭示了必要的结构动机(即,邻甲氧基取代的苯,哌嗪和嘧啶).对glut2的选择性非常好,并且最初的体外和体内药代动力学(pk)研究令人鼓舞.
Doi:10.1016/j.Bmcl.2016.02.050

专利信息

专利号:US-12180182-B2
优先权日:2021-12-01
标题 :(Di)amination of activated allene compounds, derivatives thereof, and methods for synthesis of the same
发明人：DAI MINGJI
权利人:PURDUE RESEARCH FOUNDATION
摘要:One-pot synthesis methods for producing amines from activated allenes and derivatives thereof are provided, as well as the compounds produced thereby.

专利号:US-10266503-B1
优先权日:2016-05-24
标 题 :Sulfoxide ligand metal catalyzed oxidation of olefins
发明人：WHITE M CHRISTINA; AMMANN STEPHEN E; LIU WEI; MA RULIN
权利人:UNIV ILLINOIS
摘要:The enantioselective synthesis of isochroman motifs has been accomplished via Pd(II)-catalyzed allylic C—H oxidation from terminal olefin precursors. Critical to the success of this goal was the development and utilization of a novel chiral aryl sulfoxide-oxazoline (ArSOX) ligand. The allylic C—H oxidation reaction proceeds with the broadest scope and highest levels asymmetric induction reported to date (avg. 92% ee, 13 examples ≥90% ee). Additionally, C(sp 3 )-N fragment coupling reaction between abundant terminal olefins and N-triflyl protected aliphatic and aromatic amines via Pd(II)/sulfoxide (SOX) catalyzed intermolecular allylic C—H amination is disclosed. A range of 52 allylic amines are furnished in good yields (avg. 76%) and excellent regio- and stereoselectivity (avg. >20:1 linear:branched, >20:1 E:Z). For the first time, a variety of singly activated aromatic and aliphatic nitrogen nucleophiles, including ones with stereochemical elements, can be used in fragment coupling stiochiometries for intermolecular C—H amination reactions.

专利号:US-2005019747-A1
优先权日:2002-08-07
标 题 :Nanoliter-scale synthesis of arrayed biomaterials and screening thereof
发明人：ANDERSON DANIEL G; LEVENBERG SHULAMIT; LANGER ROBERT S
摘要:A method of screening cell-polymer interactions. The method includes depositing monomers as a plurality of discrete elements on a substrate, causing the deposited monomers to polymerize, thereby creating an array of discrete polymer elements on the substrate, incubating the substrate in a cell-containing culture medium, and characterizing a predetermined cell behavior on each polymer element.

专利号:WO-2024134480-A1
优先权日:2022-12-21
标题:Heterocyclic acrylic acid derivatives as monomers for the synthesis of polymers for use in ion exchange articles
发明人：RASMUSSEN JERALD K; HOCHSTEIN REBECCA A; FISHMAN JOSHUA M; VOLOSHIN ALEXEI M; WATTS ANNABELLE; RICHARDSON KRISTOPHER E; BISHOP LOGAN D C; GRIESGRABER GEORGE W; WLASCHIN KATIE F; COLAK ATAN SEMRA; JULIK EMILY; VAIL ANDREW W
权利人:3M INNOVATIVE PROPERTIES COMPANY
摘要:The present invention relates to monomers of formula (I) having a nitrogen atom that can be protonated at relatively low pH values (e.g., less than pH 9.5 or less than pH 9), polymers containing monomeric units derived from these monomers, anion exchange separation articles having the polymers grafted to a porous substrate, and methods of using the anion separation articles to separate mixtures of materials with different ionic content are described. Advantageously, the anion exchange separation articles can be used to separate biomaterials that cannot be subjected to high pH conditions (e.g., greater than 9 or 9.5) and/or to high ionic strength conditions (e.g., greater than 0.5M or 1M).

专利号:US-2004249147-A1
优先权日:2001-09-25
标题:Synthesis of key azole-antifungal intermediates
发明人：SATTIGERI JITENDRA; ARORA JASBIR SINGH; MALHOTRA SANJAY; VERMA ASHWANI KUMAR; SALMAN MOHAMMAD
摘要:Methods for producing azole compounds useful as intermediates for antifungal compounds and compositions including reaction of epoxy alcohols with reactants having active hydrogen attached to nitrogen, oxygen or sulfur in the presence of redox coupling agents. In some embodiments, a procedure known as a Mitsunobu reaction is utilized for the transformations.

专利号:WO-9919297-A9
优先权日:1997-10-15
标题 :Synthesis of azetidine derivatives
发明人：CHEN ZHENGMING; KOLB HARTMUTH C; RICHARDSON PAUL; HUANG ZHI-MIN
权利人:COELACANTH CHEMICAL CORP; CHEN ZHENGMING; KOLB HARTMUTH C; RICHARDSON PAUL; HUANG ZHI MIN
摘要:The present invention provides compound having formula (I) useful as building blocks for combinatorial libraries and methods of making such compounds. Also provided are compositions comprising the compounds.