CAS: 6104-58-1; Sodium 3-(((4-((4-((4-Ethoxyphenyl)Amino)Phenyl)(4-(Ethyl(3-Sulfonatobenzyl)Iminio)-2-Methylcyclohexa-2,5-Dien-1-Ylidene)Methyl)-3-Methylphenyl)(Ethyl)Amino)Methyl)Benzenesulfonate

专利信息

专利号:WO-2023169082-A1
优先权日:2022-10-24
标 题:Synthesis method and application of benzothiadiazole-1-ketone compound and derivative thereof
发明人：YI WEI; ZHOU ZHI; WU LIEXIN
权利人:UNIV GUANGZHOU MEDICAL
摘要:Disclosed in the present invention are a synthesis method and application of a benzoselenazole-1-ketone compound and a derivative thereof. Sulfoximine and the element selenium are used as raw materials, and by means of a rhodium catalysis direct C-H functionalization reaction, synthesis of a series of benzoselenazole-1-ketone compounds is achieved. The solution has the advantages of strong functional group compatibility, wide substrate universality, mild conditions, simple operations, and high efficiency and universality. Meanwhile, sulfoximine and the element selenium are used as initial raw materials, a direct C-H functionalization reaction is carried out, and by means of chiral phosphoric acid, synthesis of the chiral benzoselenazole-1-ketone compound is achieved. The application prospect is good, and a sulfydryl structure in biomacromolecules such as polypeptides, saccharides, drug molecules and proteins can be specifically marked. Good anti-SARS-CoV-2 virus activity is exhibited, a trastuzumab biological conjugate can effectively image HER 2 receptors on the cell surface, displays strong fluorescence, and can be applied to the preparation of an imaging reagent for the HER 2 receptor on the cell surface.

专利号:WO-2023227913-A1
优先权日:2022-05-27
标 题:Creating nucleic acids for in-vitro protein synthesis
发明人：CHEN MICHAEL CHUN HAO; MCINROY GORDON ROSS; OST TOBIAS WILLIAM BARR
权利人:NUCLERA LTD
摘要:Provided herein are methods, and compositions for the synthesis of genes and proteins. The methods are applicable to synthesis of nucleic acids and proteins on a microfluidic device.

专利号:US-2025250599-A1
优先权日:2024-02-05
标 题:POLYPHOSPHATE KINASES (PPKs) FOR EFFICIENT REGENERATION OF GUANOSINE TRIPHOSPHATE (GTP) AND USE THEREOF
发明人：LIU LUO; Cao Chenqi; WU LINBO; WANG RUIKAI; LIU CHENYUAN; JIANG LINTONG
权利人:UNIV BEIJING CHEM TECH
摘要:Polyphosphate kinases (PPKs) for efficient regeneration of guanosine triphosphate (GTP) and use thereof are provided, belonging to the field of biotechnology. The PPKs expressed and obtained in Escherichia coli BL21(DE3) can efficiently regenerate the GTP using tripolyphosphate (tripolyP), tetrapolyP, and hexametaphosphate as phosphate donors. Use of the PPKs in regeneration of GTP as well as synthesis of guanosine diphosphate (GDP)-L-fucose or GDP-mannose and a derivative thereof (such as fucosyllactose) significantly improves synthesis sustainability and reduces a synthesis cost.

专利号:US-12410456-B2
优先权日:2015-12-30
标题:Cell-free glycoprotein synthesis (CFGPS) in prokaryotic cell lysates enriched with components for glycosylation
发明人：JEWETT MICHAEL CHRISTOPHER; STARK JESSICA CAROL; DELISA MATTHEW P; JAROENTOMEECHAI THAPAKORN
权利人:UNIV NORTHWESTERN; UNIV CORNELL
摘要:Disclosed are components and systems for cell-free glycoprotein synthesis (CFGpS). In particular, the components and systems include and utilize prokaryotic cell lysates from engineered prokaryotic cell strains that have been engineered to enable cell-free synthesis of glycoproteins.

专利号:US-2024409571-A1
优先权日:2023-06-08
标 题:Chemoenzymatic synthesis of n-acetylated gangliosides and glycosphingosines
发明人：CHEN XI; YU HAI; MISHRA BIJOYANANDA; ZHENG ZIMIN; AGRAHARI ANAND KUMAR; GUCCHAIT ARIN
权利人:UNIV CALIFORNIA
摘要:Described herein are novel stable 9-N-, 8-N-, and 7-N-acetyl analogues of instable 9-O-acetyl, 8-O-acetyl, and 7-O-acetyl b-series gangliosides and glycosphingosines, including GD3, GD2, GD1b, GT1b, GQ1b, and their glycosphingosines. Chemoenzymatic methods for the production of the stable 9-N-, 8-N-, and 7-N-acetyl analogues are also described herein.

专利号:US-2024424116-A1
优先权日:2023-06-16
标题:Pegylated-AU(III) Reagents for Rapid Cysteine S-Arylation of Biomolecules
发明人：MAYNARD HEATHER D; SPOKOYNY ALEXANDER; AYTAC HAYDEN MONTGOMERY; MESSINA MARCO; DOUD EVAN
权利人:UNIV CALIFORNIA
摘要:Compositions and methods for cysteine arylation of polypeptides using Au(III) organometallic complexes are disclosed herein. The bioconjugation reactions proceed rapidly at ambient temperature in various buffers. The compositions and methods enable the synthesis of PEGylated polypeptide conjugates with selectivity and high efficiency, allowing facile modification of complex biomolecules.