CAS: 73781-91-6; Methyl 6-Chloronicotinate

相似化合物

23100-12-1 5326-23-8 21543-49-7

上下游产品

CAS号67-56-1 甲醇 | CAS号5326-23-8 6-氯烟酸 | CAS号74-88-4 碘甲烷 | CAS号58757-38-3 6-氯吡啶-3-羰酰氯 | CAS号21543-49-7 6-氯吡啶-3-甲醇 | CAS号23100-12-1 6-氯吡啶-3-甲醛 | CAS号18107-18-1 (三甲硅烷)重氮甲烷 | CAS号26218-80-4 6-甲氧基烟酸甲酯 | CAS号186581-53-3 重氮甲烷 | CAS号365413-29-2 6-氯-5-碘烟酸甲酯 | CAS号111205-01-7 METHYL 6-(1H-IM... | CAS号321533-62-4 6-吡唑-1-基烟酸甲酯 | CAS号39891-09-3 2-氯-5-吡啶乙腈 | CAS号51362-38-0 6-苯氧基烟酸 | CAS号4634-13-3 6-苯基烟酸甲酯 | CAS号220339-96-8 2,2-联吡啶-5-甲胺 | CAS号1970-80-5 2,2-联吡啶-5-羧酸 | CAS号78686-77-8 5-溴-6-氯烟酸甲酯 | CAS号63056-20-2 6-苯基吡啶-3-甲醛 | CAS号70258-18-3 2-氯-5-氯甲基吡啶

5-碘-6-氧代-1H-吡啶-3-羧酸甲酯置于copper(L) Iodide,1,10-菲罗啉,(三氟甲基)三甲基硅烷,N,N-二异丙基乙胺,三氯氧磷体系中,用 1,4-二氧六环 作为反应溶剂,化学反应 7.0H,反应生成 6-氯烟酸甲酯
参考文献:安全和经济合成6-氯-5-(三氟甲基)烟酸甲酯的开发:千克级的三氟甲基化
标题:安全和经济合成6-氯-5-(三氟甲基)烟酸甲酯的开发:千克级的三氟甲基化
摘要:本文报道了6-氯-5-(三氟甲基)烟酸甲酯的安全和经济的合成,它是合成新型抗感染剂的中间体.该方法的关键是使用廉价的氯代二氟乙酸甲酯(mcdfa)/ Kf / Cui系统对芳基碘进行三氟甲基化,重点是导致这一有效方法的开发工作.
DOI:10.1021/op400061W

专利信息

专利号:US-8686157-B2
优先权日:2003-02-10
标题:Processes for the facile synthesis of diaryl amines and analogues thereof
发明人：SNOONIAN JOHN R; OLIVER-SHAFFER PATRICIA ANN
权利人:SNOONIAN JOHN R; OLIVER-SHAFFER PATRICIA ANN; VERTEX PHARMA
摘要:The present invention relates to processes for the facile synthesis of diaryl amines and analogues thereof. The processes of the present invention produce diaryl amines in high yield and purity. The present invention also relates to intermediates useful in the process of the present invention.

专利号:US-11623929-B2
优先权日:2018-06-04
标 题 :Spirocyclic compounds
发明人：NASVESCHUK CHRISTOPHER G; DEY FABIAN; GOERGLER ANNICK; NORCROSS ROGER; SCHMID PHILIPP
权利人:C4 THERAPEUTICS INC
摘要:The present invention provides compounds and intermediates. The present invention also provides compounds which bind to the ubiquitously expressed E3 ligase protein cereblon (CRBN) and their use for the treatment of abnormal cellular proliferation. The present invention also provides compounds that may be used as synthetic intermediates in the synthesis of bifunctional compounds used for targeted protein degradation.

专利号:US-2007173649-A1
优先权日:2003-02-10
标 题:Processes for the facile synthesis of diaryl amines and analogues thereof

专利号:US-11225473-B2
优先权日:2019-01-15
标题:FXR (NR1H4) modulating compounds
发明人：BLOMGREN PETER A; CURRIE KEVIN S; FRICK MORIN MAE; HORSTMAN ELIZABETH M; KAPLAN JOSHUA A; KROPF JEFFREY E; WATKINS WILLIAM J
权利人:GILEAD SCIENCES INC
摘要:The present disclosure relates generally to compounds that bind to FXR and act as agonists of FXR. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.

专利号:US-8034950-B2
优先权日:2003-02-10
标题:Processes for the facile synthesis of diaryl amines and analogues thereof

专利号:US-2012157684-A1
优先权日:2003-02-10
标题:Processes for the facile synthesis of diaryl amines and analogues thereof