CAS: 7432-21-5; (S)-2-(((Benzyloxy)Carbonyl)Amino)-3-(1H-Indol-3-yl)Propanoic Acid

上下游产品

benzyl chloroformate L-Tryptophan N-α-carbobenzoxy-L-tyrosine p-nitrophenyl ester dibenzyl dicarbonateNα-benzyloxycarbonyl-tryptophan)-[5']inosinic acid-anhydride(Nα-benzyloxycarbonyl-tryptophan)-[5']inosinic acid-anhydride Z-Trp-Gly-Gly-OH N-carbobenzyloxy-L-tryptophanyl-L-isoleucine methyl ester S-benzyl-N-(Nα-benzyloxycarbonyl-L-tryptophyl)-L-cystein-ethyl esterS-benzyl-N-(Nα-benzyloxycarbonyl-L-tryptophyl)-L-cystein-ethyl ester

(S)-N-Benzyloxycarbonyl-L-Tryptophan Methyl Ester置于水,Lithium Hydroxide,盐酸体系中,用 四氢呋喃,水 作为反应溶剂,化学反应 3.0H,反应生成 N-苄氧羰基-L-色氨酸
参考文献:色氨酸-六氢吡咯并吲哚合成中的正交保护基团
标题:色氨酸-六氢吡咯并吲哚合成中的正交保护基团
摘要:此处描述了在六氢吡咯并 [2,3-B] 吲哚和吲哚色氨酸之间包含 Ac3A-Ni 键的各种多环系统的合成.进行了一系列实验以确定五个正交保护基团的最佳组合和形成所述键的最佳反应条件,这是许多最近发现的海洋天然产物的共同特征.
DOI:10.1002/ejoc.201101057

专利信息

专利号:US-7435791-B2
优先权日:2001-07-19
标题:Process for rapid solution synthesis of peptides
发明人：EGGEN IVO FRANCI; TEN KORTENAAR PAULUS BERNARDUS; HAASNOOT CORNELIS ALBERT GRUSON
权利人:ORGANON NV
摘要:The present invention relates to a process for rapid solution synthesis of a peptide, the process comprising repetitive cycles of steps (a)-(d):n (a) a coupling step, using an excess of an activated carboxylic component to acylate an amino component, (b) a quenching step in which a scavenger is used to remove residual activated carboxylic functions, wherein the scavenger may also be used for deprotection of the growing peptide, (c) one or more aqueous extractions and optionally, (d) a separate deprotection step, followed by one or more aqueous extractions, characterised in that the process comprises at least one step (b), referred to as step (b′), in which an amine or a thiol comprising a free anion or a latent anion is used as a scavenger of residual activated carboxylic functions. nn During the process of this invention the growing peptide need not be isolated until the final peptide sequence has been obtained. n This highly efficient process is useful for the production of oligo- and polypeptides of high purity.

专利号:US-11414375-B2
优先权日:2016-07-29
标题:Mild and efficient preparation method for α-acyloxyenamide compounds and use thereof in synthesis of amide and polypeptide
发明人：ZHAO JUNFENG; HU LONG; XU SILIN; ZHAO ZHENGUANG
权利人:UNIV JIANGXI NORMAL
摘要:Disclosed are a mild and efficient preparation method for an α-acyloxyenamide compound and a use thereof in the synthesis of an amide and a polypeptide. The α-acyloxyenamide compound is obtained by an addition reaction of a ynamide and a carboxylic acid in dichloromethane under conditions where the temperature is 0° C. to 50° C.; the produced α-acyloxyenamide compound can react with an amine compound to produce an amide or a polypeptide; the two reactions can be carried out step by step, and can also be carried out in one pot. According to the invention, the reaction conditions are mild and no metal catalyst is required; when the carboxylic acid, which has chirality on an alpha site of carboxyl, forms an amide bond or a peptide bond, no racemization occurs; and the operation is simple and the application range is wide.

专利号:US-2024218014-A1
优先权日:2022-11-21
标 题:Synthesis of a cyclic peptide
发明人：BAUR PIUS BRUNO; CLEATOR EDWARD; DENIAU GILDAS; EISELE FRANK; FLÖGEL OLIVER; HUSTE ANJA; KEHL MARCEL ROMAN; LÖWENECK MARKUS; SILVA ROLANDO RAVELO; VORBERG RAFFAEL
权利人:JANSSEN PHARMACEUTICA NV
摘要:Processes for performing peptide synthesis, particularly for cyclic peptide synthesis are generally described. Reaction intermediates of the peptide synthesis are also described.

专利号:US-2023220001-A1
优先权日:2020-06-09
标 题:Method for synthesis of thioether-containing peptides
发明人：GRUSS HENDRIK; LUTZ CHRISTIAN; SÃœSSMUTH RODERICH; Yao guiyang; KNITTEL CAROLINE; KOSOL SIMONE; MAINZ ANDI
权利人:HEIDELBERG PHARMA RES GMBH
摘要:The present invention relates to a method of formation of a sulphur bridge between tryptophan and cysteine in solid phase peptide synthesis under iodine treatment. The invention also relates to the resulting compounds of the method and their respective use.

专利号:US-3953416-A
优先权日:1971-12-20
标 题:Synthetic decapeptide having the activity of the luteinizing hormone releasing hormone and method for manufacturing the same
发明人：FOLKERS KARL; CURRIE BRUCE L; CHANG JAW-KANG; SIEVERTSSON HANS; BOGENTOFT CONNY
权利人:FOLKERS KARL; CURRIE BRUCE L; CHANG JAW KANG; SIEVERTSSON HANS; BOGENTOFT CONNY
摘要:A synthetic decapeptide, L-pglutamyl-L-histidyl-L-tryptophanyl-L-seryl-L-tyrosyl-glycyl-L-leucy l-L-arginyl-L-prolyl-glycinamide which has the hormonal activities of the luteinizing hormone releasing hormone (LRH) of the hypothalamus gland of mammals is produced by utilizing as the key starting materials, the amino acids, glutamic acid or pyroglutamic acid, histidine, tryptophan, serine, tyrosine, glycine, leucine, arginine, and proline. Synthesis of the decapeptide is accomplished by coupling, in appropriate combinations of appropriate protected forms of the amino acids, and finally deprotecting to yield the amide, L-pglutamyl-L-histidyl-L-tryptophanyl-L-seryl-L-tyrosyl-glycyl-L-leucy l-L-arginyl-L-prolyl-glycinamide.

专利号:BR-PI0202783-B1
优先权日:2001-07-19
标 题:process for the rapid synthesis of a peptide in solution in an organic solvent or a mixture of organic solvents, and methods for the combinatorial synthesis of peptide collections and for automated solution peptide synthesis