CAS: 88-14-2; Furan-2-Carboxylic Acid

• 英文名称Furan-2-Carboxylic Acid
• 中文名称2-呋喃甲酸
• IUPAC名称furan-2-carboxylic acid
• 其它别名2-呋喃甲酸; 糠酸; Pyromucic Acid
• CAS编号88-14-2
• MFCD编号:MFCD00003238
• EINECS号:201-803-0
• 分子式:C5H4O3
• 分子量:112.08
• 产品CID: 1890624
• 产品分类有机原料→分子砌块→芳杂环类化合物→呋喃类化合物

• 相似结构搜索
• InChIKey: SMNDYUVBFMFKNZ-UHFFFAOYSA-N
• InChI=1S/C5H4O3/c6-5(7)4-2-1-3-8-4/h1-3H,(H,6,7)…
• 计算化学: 氢键受体数2.0氢键供体数1.0可旋转键数1.0

相似化合物

物理性质

• 熔点128-132°C
• 沸点230-232°C at 760 mmHg
• 闪点137 °C
• 密度1.3±0.1 g/cm3
• pKa:3.16(at 25°C)
• PSA:50.44
• LogP:0.9778
• 折射率1.513
• 蒸汽压0.0±0.5 mmHg at 25°C
• 溶解性37G/l
• 敏感性1. 存在于烤烟烟叶、白肋烟烟叶、香料烟烟叶、烟气中。
• 外观形态类白色至米色细结晶粉末
• 储存条件置于阴暗处,密封, 常温干燥保存
• 产品应用糠酸用于合成甲基呋喃,糠酰胺及糠酸酯和盐.在塑料工业中可用于增塑剂,热固性树脂等.在食品工业中用作防腐剂,也用作涂料添加剂,医药.香料等的中间体.
• 性质描述白色单斜长梭形结晶.熔点133-134°C.沸点230-232°C,141-144°C(2.62kPa).1g该品可溶于26ml冷水或4ml沸水,易溶于乙醇和乙醚.在130-140°C(6.65-8kPa)升华.

MSDS等安全信息

• GHS象形图
• GHS符号GHS07;
  注释: Exclamation mark
• 危险类别特定目标器官毒性 - 单次接触 类别3
  皮肤腐蚀/刺激 类别2
  严重眼刺激 类别2
  皮肤腐蚀 类别1C
  严重眼损伤 类别1
  急性毒性 类别4(吸入)
  急性毒性 类别4(经皮)
  急性毒性 类别4(经口)
  严重眼刺激 类别2A
• 警示词Warning(警告)
• 危险描述H335 |可能引起呼吸道刺激.
  H315 |造成皮肤刺激.
  H319 |造成严重眼刺激.
  H314 |造成严重皮肤灼伤和眼损伤.
  H318 |造成严重眼损伤.
  H332 |吸入有害.
  H312 |皮肤接触有害.
  H302 |吞咽有害.
• 防范说明P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501
• 危险等级8
• UN编号1759.0
• 危险品标志C,Xi
• 包装等级Ⅲ
• 安全声明26-36/37/39-45-36-37/39
• 危险类别码34-36/37/38
• WGK Germany3.0

欧盟法规

上下游产品

合成工艺路线路线简述

• 611-13-2 = 88-14-2
  反应条件:1.1 Reagents: Thiophenol Catalysts: Potassium Carbonate Solvents: N-Methyl-2-Pyrrolidone
  标题:A Mild And Chemoselective Method For Ester O-Alkyl Cleavage Using In Situ Generated Potassium Thiophenoxide From Catalytic Quantities Of Base
  作者:Sharma,Lalima; Et Al
  参考文献:Tetrahedron 日期:1999 卷标:55(31) 页码:9595-9600]
  
  611-13-2 = 88-14-2
  反应条件:1.1 Reagents: Thiophenol Catalysts: Potassium Fluoride Solvents: N-Methyl-2-Pyrrolidone
  标题:Influence Of Hydrogen Bonding In The Activation Of Nucleophiles: Phsh-(Catalytic) Kf In N-Methyl-2-Pyrrolidone As An Efficient Protocol For Selective Cleavage Of Alkyl/aryl Esters And Aryl Alkyl Ethers Under Nonhydrolytic And Neutral Conditions
  作者:Chakraborti,Asit K.; Et Al
  参考文献:Journal Of Organic Chemistry 日期:2002 卷标:67(8) 页码:2541-2547]
  
  = 88-14-2
  反应条件:1.1 Reagents: Potassium Hydroxide Catalysts: Nickel Selenide,Selenium,Iron-Nickel Alloy Solvents: Water; Rt
  标题:Grass-Like Nixsey Nanowire Arrays Shelled With Nife Ldh Nanosheets As A 3D Hierarchical Core-Shell Electrocatalyst For Efficient Upgrading Of Biomass-Derived 5-Hydroxymethylfurfural And Furfural
  作者:Zhong,Yan; Et Al
  参考文献:Catalysis Science & Technology 日期:2022 卷标:12(1) 页码:201-211]
  
  = 88-14-2
  反应条件:1.1 Reagents: Calcium Carbonate Solvents: Water; 5 H,Ph 7,30 °C
  标题:A Versatile Pseudomonas Putida Kt2440 With New Ability: Selective Oxidation Of 5-Hydroxymethylfurfural To 5-Hydroxymethyl-2-Furancarboxylic Acid
  作者:Xu,Qianqian; Et Al
  参考文献:Bioprocess And Biosystems Engineering 日期:2020 卷标:43(1) 页码:67-73]
  
  16737-36-3 = 88-14-2
  反应条件:1.1 Reagents: Silica; 3.5 H,120 °C
  标题:Solvent-Free Cleavage Of Tert-Butyl Esters Under Microwave Conditions
  作者:Park,Doo Han; Et Al
  参考文献:Bulletin Of The Korean Chemical Society 日期:2009 卷标:30(1) 页码:230-232]
  
  617-90-3 = 88-14-2
  反应条件:1.1 Reagents: Iodine Solvents: Dimethyl Sulfoxide; 30 Min1.2 Reagents: Sodium Thiosulfate1.3 Catalysts: Amidase,Nitrile Hydratase Solvents: Water; 60 Min
  标题:Control Of The Nitrile-Hydrolyzing Enzyme Activity In Rhodococcus Rhodochrous Ifo 15564: Preferential Action Of Nitrile Hydratase And Amidase Depending On The Reaction Condition Factors And Its Application To The One-Pot Preparation Of Amides From Aldehydes
  作者:Kashiwagi,Mieko; Et Al
  参考文献:Journal Of Molecular Catalysis B: Enzymatic 日期:2004 卷标:29(1-6) 页码:249-258]
  
  326-90-9 = 88-14-2
  反应条件:1.1 Reagents: Sodium Bicarbonate,Oxygen Catalysts: Tris(2,2′-Bipyridyl)Ruthenium(Ii) Chloride Solvents: Acetonitrile; 4 H1.2 Reagents: Hydrochloric Acid Solvents: Water; Acidified
  标题:[ru(Bpy)3]Cl2-Catalyzed Aerobic Oxidative Cleavage β-Diketones To Carboxylic Acids Under Visible Light Irradiation
  作者:Wang,Xiao-Yan; Et Al
  参考文献:Tetrahedron Letters 日期:2016 卷标:57(50) 页码:5628-5631]
  
  552-86-3 = 88-14-2
  反应条件:1.1 Reagents: Sulfuric Acid Magnesium Salt (1:1),Hydrogen Peroxide Catalysts: Methyltrioxorhenium Solvents: Acetonitrile,Water; 1.5 H,Reflux1.2 Reagents: Manganese Oxide (Mno2)
  标题:Methyltrioxorhenium-Catalyzed Oxidative Cleavage Of α-Hydroxycarbonyl Compounds To Carboxylic Acids With Hydrogen Peroxide
  作者:Jain,Suman L.; Et Al
  参考文献:Synthetic Communications 日期:2003 卷标:33(22) 页码:3875-3878]
  
  552-86-3 = 88-14-2
  反应条件:1.1 Reagents: Sodium Hypochlorite Solvents: Water
  标题:Oxidation Of α-Substituted Carbonyl Compounds To Carboxylic Acids In Aqueous Media Using Ultrasound
  作者:Yang,D. T. C.; Et Al
  参考文献:Synthetic Communications 日期:1997 卷标:27(9) 页码:1601-1605]
  
  552-86-3 = 88-14-2
  反应条件:1.1 Reagents: Sodium Hypochlorite Solvents: Water
  标题:Microwave-Assisted Oxidation Of α-Substituted Carbonyl Compounds To Carboxylic Acids In Aqueous Media
  作者:Yang,D. T. C.; Et Al
  参考文献:Synthetic Communications 日期:1997 卷标:27(18) 页码:3235-3239]
  
  534-22-5 = 88-14-2
  反应条件:1.1 Reagents: Oxygen Catalysts: Pyridinium,1-(4-Sulfobutyl)-,1,1,1-Trifluoromethanesulfonate (1:1) Solvents: Acetonitrile; 6 H,1 Atm,20 °C
  标题:Bronsted Acid-Catalysed Aerobic Photo-Oxygenation Of Benzylic C-H Bonds
  作者:Wu,Jieqing; Et Al
  参考文献:Green Chemistry 日期:2023 卷标:25(3) 页码:940-945]
  
  4741-45-1 = 88-14-2
  反应条件:1.1 Reagents: Dimethyl Sulfoxide,Perfluorobutyl Iodide; 25 H,Rt
  标题:Transformation Of Thioacids Into Carboxylic Acids Via A Visible-Light-Promoted Atomic Substitution Process
  作者:Wang,Rui; Et Al
  参考文献:Organic Letters 日期:2022 卷标:24(10) 页码:2020-2024]
  
  941320-88-3 = 88-14-2
  反应条件:1.1 Reagents: Potassium Tert-Butoxide Catalysts: [1,3-Bis[2,6-Bis(Diphenylmethyl)-4-Methylphenyl]-1,3-Dihydro-2H-Imidazol-2-Ylide... Solvents: Toluene; 100 °C; 15 H,1 Atm,100 °C; 100 °C -> Rt1.2 Reagents: Hydrochloric Acid Solvents: Ethyl Acetate,Water; Rt
  标题:Nickel-Catalysed Carboxylation Of Organoboronates
  作者:Makida,Yusuke; Et Al
  参考文献:Chemical Communications (Cambridge 日期:2014 卷标:50(59) 页码:8010-8013]
  
  941320-88-3 = 88-14-2
  反应条件:1.1 Reagents: Potassium Tert-Butoxide Catalysts: [1,3-Bis[2,6-Bis(1-Methylethyl)Phenyl]-1,3-Dihydro-2H-Imidazol-2-Ylidene]Chloroc... Solvents: Tetrahydrofuran; 1 Atm,Rt; 24 H,70 °C1.2 Reagents: Hydrochloric Acid Solvents: Water; Acidified
  标题:Carboxylation Of Organoboronic Esters Catalyzed By N-Heterocyclic Carbene Copper(I) Complexes
  作者:Ohishi,Takeshi; Et Al
  参考文献:Angewandte Chemie 日期:2008 卷标:47(31) 页码:5792-5795]
  
  614-99-3 = 88-14-2
  反应条件:1.1 Reagents: Potassium Hydroxide Solvents: Methanol; 35 °C
  标题:Synthesis,Biological Evaluation And Molecular Docking Studies Of Indeno[1,2-C]Pyrazole Derivatives As Inhibitors Of Mitochondrial Malate Dehydrogenase 2 (Mdh2)
  作者:Ahmadi,Farzaneh; Et Al
  参考文献:Bioorganic Chemistry 日期:2021 卷标:110]
  
  17090-71-0 = 88-14-2
  反应条件:1.1 Catalysts: Iodine Solvents: Dimethyl Sulfoxide; 5 Min,180 °C
  标题:Dmso/i2 Mediated C-C Bond Cleavage Of α-Ketoaldehydes Followed By C-O Bond Formation: A Metal-Free Approach For One-Pot Esterification
  作者:Venkateswarlu,Vunnam; Et Al
  参考文献:Organic & Biomolecular Chemistry 日期:2015 卷标:13(29) 页码:7973-7978]
  
  = 88-14-2
  反应条件:1.1 Reagents: Tert-Butyl Hydroperoxide,Sodium Hydroxide Catalysts: Sodium Chloride Solvents: Water; 8 H,90 °C1.2 Reagents: Hydrochloric Acid Solvents: Water; Neutralized
  标题:A Simple And Efficient Oxidation Of Primary And Secondary Benzylamines To Acids Using Table Salt In Aqueous Medium
  作者:Kushawaha,Ajay Kishor; Et Al
  参考文献:Tetrahedron 日期:2021 卷标:101]
  
  611-13-2 = 88-14-2
  反应条件:1.1 Reagents: Aluminum,Iodine Solvents: Acetonitrile; 18 H,80 °C; 80 °C -> Rt1.2 Reagents: Hydrochloric Acid Solvents: Water
  标题:Cleavage Of Carboxylic Esters By Aluminum And Iodine
  作者:Sang,Dayong; Et Al
  参考文献:Journal Of Organic Chemistry 日期:2021 卷标:86(5) 页码:4254-4261]
  
  = 88-14-2
  反应条件:1.1 Reagents: Sodium Hydroxide,Oxygen Catalysts: Palladium Solvents: Water; 36 H,1 Atm,80 °C1.2 Reagents: Hydrochloric Acid Solvents: Water
  标题:Cubic Nanocasted Polyaniline-Ordered Mesoporous Carbon Composite And Its Application For Enhanced Catalytic Activity Of Palladium Nanoparticles In The Aerobic Oxidation Of Alcohols In Water
  作者:Najafvand-Derikvandi,Sepideh; Et Al
  参考文献:Molecular Catalysis 日期:2020 卷标:496]
  
  = 88-14-2
  反应条件:1.1 Reagents: Oxygen Catalysts: Galactose Oxidase,Xanthine Dehydrogenase Solvents: Acetonitrile,Water; 16 H,Ph 7.6,37 °C1.2 Reagents: Hydrochloric Acid Solvents: Water; Acidified
  标题:Catalytic Bio-Chemo And Bio-Bio Tandem Oxidation Reactions For Amide And Carboxylic Acid Synthesis
  作者:Bechi,Beatrice; Et Al
  参考文献:Green Chemistry 日期:2014 卷标:16(10) 页码:4524-4529]
  
  = 88-14-2
  反应条件:1.1 Reagents: M-Chloroperbenzoic Acid Catalysts: N-Hydroxyphthalimide,Iodobenzene Solvents: Acetonitrile,Water; 4 H,Rt1.2 Reagents: Sodium Thiosulfate Solvents: Diethyl Ether,Water; 10 Min,Rt
  标题:Catalytic Hypervalent Iodine Oxidation Of Alcohols To The Corresponding Carbonyl Compounds Using N-Hydroxyphthalimide (Nhpi) And M-Chloroperbenzoic Acid
  作者:Zhu,Chenjie; Et Al
  参考文献:Canadian Journal Of Chemistry 日期:2010 卷标:88(4) 页码:362-366]
  
  = 88-14-2
  反应条件:1.1 Reagents: Oxygen Catalysts: Magnesium Nitrate,Hydrotalcite (Mg6(Co3)[al(Oh)6]2(Oh)4.4H2O),Aluminum Nitrate Solvents: Water; 2 H,6 Bar,110 °C
  标题:Liquid Phase Furfural Oxidation Under Uncontrolled Ph In Batch And Flow Conditions: The Role Of In Situ Formed Base
  作者:Roselli,Alessandra; Et Al
  参考文献:Catalysts 日期:2020 卷标:10(1)]
  
  5380-40-5 = 88-14-2
  反应条件:1.1 Reagents: Nickel Dichloride,Sodium Borohydride Solvents: Methanol; 10 Min,Rt1.2 Reagents: Methanol
  标题:Rapid Chemoselective Deprotection Of Benzyl Esters By Nickel Boride
  作者:Khurana,Jitender M.; Et Al
  参考文献:Synthesis 日期:2009 卷标:(7) 页码:1127-1130]
  
  617-90-3 = 88-14-2 [标题:Reaction Conditions
  标题:Synthesis Of Amides From Carboxylic Acids And Derivatives
  作者:Ziegler,T.
  参考文献:Science Of Synthesis 日期:2005 卷标:21 页码:43-75]
  
  617-90-3 = 88-14-2 [标题:Reaction Conditions
  标题:Purification And Characterization Of Nitrilase Responsible For The Enantioselective Hydrolysis From Acinetobacter Sp. Ak 226
  作者:Yamamoto,Keizou; Et Al
  参考文献:Agricultural And Biological Chemistry 日期:1991 卷标:55(6) 页码:1459-66]
  
  1192-62-7 = 88-14-2
  反应条件:1.1 Reagents: Hydroxyamine Hydrochloride,Oxygen Catalysts: Iodine Solvents: Dimethyl Sulfoxide; 5 H,100 °C
  标题:Iodine-Catalyzed Oxidative C-C Bond Cleavage For Benzoic Acids And Benzamides From Alkyl Aryl Ketones
  作者:Sathyanarayana,Pochampalli; Et Al
  参考文献:Rsc Advances 日期:2016 卷标:6(27) 页码:22749-22753]
  
  1192-62-7 = 88-14-2
  反应条件:1.1 Reagents: Dimethyl Sulfoxide Catalysts: Iodine Solvents: Chlorobenzene; 110 °C; 110 °C -> Rt1.2 Reagents: Tert-Butyl Hydroperoxide; 110 °C1.3 Reagents: Water1.4 Reagents: Sodium Hydroxide Solvents: Water; Ph 111.5 Reagents: Hydrochloric Acid Solvents: Water; Ph 2
  标题:Oxidative C-C Bond Cleavage For The Synthesis Of Aryl Carboxylic Acids From Aryl Alkyl Ketones
  作者:Xu,Liang; Et Al
  参考文献:Synlett 日期:2018 卷标:29(11) 页码:1505-1509]
  
  = 88-14-2
  反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Water; 9 H,100 °C1.2 Reagents: Hydrochloric Acid Solvents: Water; Acidified
  标题:Dithioester-Enabled Chemodivergent Synthesis Of Acids,Amides And Isothiazoles Via C-C Bond Cleavage And C-O/c-N/c-S Bond Formations Under Metal- And Catalyst-Free Conditions
  作者:Soni,Sonam; Et Al
  参考文献:Tetrahedron Letters 日期:2017 卷标:58(25) 页码:2512-2516]
  
  534-22-5 = 88-14-2
  反应条件:1.1 Reagents: Potassium Persulfate,Oxygen Catalysts: Molybdate(3-),Chromatehexa-μ3-Hydroxyhexa-μ-Oxododecaoxohexa-,Ammonium (1:3) Solvents: Water; 24 H,50 °C
  标题:An Efficient Chromium(Iii)-Catalyzed Aerobic Oxidation Of Methylarenes In Water For The Green Preparation Of Corresponding Acids
  作者:Jiang,Feng; Et Al
  参考文献:Dalton Transactions 日期:2021 卷标:50(36) 页码:12413-12418]
  
  534-22-5 = 88-14-2
  反应条件:1.1 Reagents: Oxygen Catalysts: Hydrochloric Acid,6-Bromobenzothiazole Solvents: Acetonitrile,Water; 24 H,30 °C1.2 Reagents: Sodium Bicarbonate Solvents: Water
  标题:Light-Promoted Chlorine-Radical-Mediated Oxidation Of Benzylic C(Sp3)-H Bonds Utilizing Air As Oxidant
  作者:Xu,Ning; Et Al
  参考文献:Advanced Synthesis & Catalysis 日期:2023 卷标:365(2) 页码:142-147]
  
  941320-88-3 = 88-14-2
  反应条件:1.1 Reagents: Potassium Tert-Butoxide Catalysts: Silver Acetate,Triphenylphosphine Solvents: Tetrahydrofuran; 16 H,20 Atm,70 °C; 70 °C -> Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; Rt
  标题:Silver(I)-Catalyzed Carboxylation Of Arylboronic Esters With Co2
  作者:Zhang,Xiao; Et Al
  参考文献:Chemical Communications (Cambridge 日期:2012 卷标:48(50) 页码:6292-6294]
  
  584-12-3 + 590-29-4 = 88-14-2
  反应条件:1.1 Catalysts: 1,1′-Bis(Di-Tert-Butylphosphino)Ferrocene,Benzoyliodo[tris(1,1-Dimethylethyl)Phosphine]Palladium Solvents: 2-Methyltetrahydrofuran; 18 H,80 °C1.2 Reagents: Sodium Bicarbonate Solvents: Water; Basified
  标题:Effective Palladium-Catalyzed Hydroxycarbonylation Of Aryl Halides With Substoichiometric Carbon Monoxide
  作者:Korsager,Signe; Et Al
  参考文献:Journal Of The American Chemical Society 日期:2013 卷标:135(8) 页码:2891-2894]
  
  614-99-3 = 88-14-2
  反应条件:1.1 Reagents: Iron Chloride (Fecl3) Solvents: 1,1,2,2-Tetrachloroethane; 24 H,115 °C; Cooled1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 4 - 6
  标题:An Efficient Fecl3-Promoted O-Alkyl Cleavage Of Esters To Carboxylic Acids
  作者:Lian,Xiaoyan; Et Al
  参考文献:Applied Organometallic Chemistry 日期:2011 卷标:25(6) 页码:443-447]
  
  609-38-1 = 88-14-2
  反应条件:1.1 Reagents: Water Catalysts: Niobium Pentoxide; 20 H,Reflux
  标题:Hydrolysis Of Amides To Carboxylic Acids Catalyzed By Nb2O5
  作者:Siddiki,S. M. A. Hakim; Et Al
  参考文献:Catalysis Science & Technology 日期:2021 卷标:11(5) 页码:1949-1960]
  
  = 88-14-2
  反应条件:1.1 Reagents: Sodium Hydroxide,Water Catalysts: (Oc-6-52)-[4,5-Bis[[bis(1-Methylethyl)Phosphino-κp]Methyl]Acridine-κn]Carbonylch... Solvents: 1,4-Dioxane; 48 H,150 °C; 150 °C -> Rt1.2 Reagents: Sodium Chloride Solvents: Water; Rt1.3 Reagents: Hydrochloric Acid Solvents: Water; Acidified,Rt
  标题:Catalytic Oxidative Deamination By Water With H2 Liberation
  作者:Tang,Shan; Et Al
  参考文献:Journal Of The American Chemical Society 日期:2020 卷标:142(49) 页码:20875-20882]
  
  = 88-14-2
  反应条件:1.1 Reagents: Sodium Hydroxide Catalysts: 2963687-38-7 Solvents: Water; 24 H,100 °C
  标题:Ni(Ii)-Catalyzed Oxidative Deamination Of Benzyl Amines With Water
  作者:Pal,Nilay Kumar; Et Al
  参考文献:Green Chemistry 日期:2023 卷标:25(16) 页码:6212-6217]
  
  = 88-14-2
  反应条件:1.1 Reagents: Ethylaluminum Dichloride,2,6-Dibromopyridine Solvents: Toluene,Hexane; 3 H,3 Mpa,60 °C1.2 Reagents: Hydrochloric Acid Solvents: Water
  标题:Etalcl2/2,6-Disubstituted Pyridine-Mediated Carboxylation Of Alkenes With Carbon Dioxide
  作者:Tanaka,Shinya; Et Al
  参考文献:Organic Letters 日期:2016 卷标:18(11) 页码:2576-2579

海关参考信息

• 2905110000-甲醇
  2912110000-甲醛
  2915110000-甲酸
  2932120000-2-糠醛
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其他信息查阅

• ➥ 象形图和危险代码
• ➥ 防范代码详解
• ➥ 危险代码说明
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• ➥ REACH监管