CAS: 123173-60-4; 2,3-Difluoro-4-Nitrophenol

该化合物是一种芳香化合物,其特点是,一种附于苯环的氢氧基(OH),该化合物被两个氟原子和一个硝基化合物(-NO2)进一步替代.氟替代成分位于与氢氧基组相对的2和3个位置,而硝基化合物组位于4个位置.该化合物显示出典型的苯性能,包括可参与氢联结的氢氧基组的中度酸性.电离子氟素的存在影响化合物的再活性和极性,有可能增强它的电极性.硝基化合物是一个强大的电离性组,也可能影响化合物的总体电子特性,使其在某些化学反应中更具反应性.此外,该化合物可能表现出不同的物理特性,例如有机溶剂溶解性以及不同熔点和沸点,受到其分子结构和子结构的影响.

英文名称2,3-Difluoro-4-Nitrophenol
中文名称2,3-二氟-4-硝基苯酚
IUPAC名称2,3-difluoro-4-nitrophenol
CAS编号123173-60-4
MFCD编号:MFCD13185572
分子式:C6H3F2NO3
分子量:175.09
产品CID: 334348
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: FCCFXVJUDSQIMG-UHFFFAOYSA-N
InChI=1S/C6H3F2NO3/c7-5-3(9(11)12)1-2-4(10)6(5)8/h1-2,10H…
计算化学: 氢键受体数3.0氢键供体数1.0可旋转键数1.0

相似化合物

163733-99-1 120103-18-6 394-41-2

MSDS等安全信息

GHS符号GHS05,GHS07,GHS09
警示词Danger
危险描述H302-H315-H317-H318-H410
防范说明P261-P264-P270-P272-P273-P280-P302+P352-P330-P362+P364-P391-P501
危险等级9
UN编号3077.0
包装等级Ⅲ

上下游产品

2,3-difluorophenol 2,3,4-trifluoronitrobenzene 3,3,4,4-tetrafluor°Cyclohexene 2,3-difluoro-1-isopropoxy-4-nitrobenzene diethyl 2-(2-fluoro-3-isopropoxy-6-nitrophenyl)malonate ethyl 2-(2-fluoro-3-isopropoxy-6-nitrophenyl)acetate 4-amino-2,3-difluoro-phenol

合成工艺路线路线简述

169468-80-8 = 123173-60-4 + 82419-26-9
反应条件:1.1 Reagents: Potassium Fluoride,1-Chloro-2,3-Difluoro-5-Nitrobenzene,2-Chloro-3,4-Difluoro-1-Nitrobenzene Catalysts: Tetramethylammonium Chloride Solvents: Dmso-D6; 7 H,130 - 135 °C2.1 Reagents: Potassium Hydroxide Solvents: Dmso-D6,Water; 2 H,18 - 20 °C; 6 H,18 - 22 °C2.2 Reagents: Water; 0 - 5 °C2.3 Reagents: Hydrochloric Acid Solvents: Water; 2 H,Ph 1,0 - 5 °C
标题:Synthesis Of Fluorinated Halonitrobenzenes And Halonitrophenols Using Tetrafluoroethylene And Buta-1,3-Dienes As Starting Building Blocks
作者:Volchkov,N. V.; Et Al
参考文献:Russian Chemical Bulletin 日期:2021 卷标:70(11) 页码:2156-2163]

= 123173-60-4 + 82419-26-9
反应条件:1.1 10 H,495 - 505 °C2.1 Reagents: Chlorine Catalysts: Iron Chloride (Fecl3) Solvents: Chloroform; 10 H,25 - 35 °C; 2 H,30 - 35 °C3.1 Reagents: Sodium Hydroxide Catalysts: Benzyltriethylammonium Chloride Solvents: Water; 2 H,25 - 45 °C; 5 H,85 - 95 °C4.1 Reagents: Sulfuric Acid,Fuming Nitric Acid; 1 H,10 - 15 °C; 2 H,15 - 20 °C5.1 Reagents: Potassium Fluoride,1-Chloro-2,3-Difluoro-5-Nitrobenzene,2-Chloro-3,4-Difluoro-1-Nitrobenzene Catalysts: Tetramethylammonium Chloride Solvents: Dmso-D6; 7 H,130 - 135 °C6.1 Reagents: Potassium Hydroxide Solvents: Dmso-D6,Water; 2 H,18 - 20 °C; 6 H,18 - 22 °C6.2 Reagents: Water; 0 - 5 °C6.3 Reagents: Hydrochloric Acid Solvents: Water; 2 H,Ph 1,0 - 5 °C
标题:Synthesis Of Fluorinated Halonitrobenzenes And Halonitrophenols Using Tetrafluoroethylene And Buta-1,3-Dienes As Starting Building Blocks
作者:Volchkov,N. V.; Et Al
参考文献:Russian Chemical Bulletin 日期:2021 卷标:70(11) 页码:2156-2163]

771-69-7 = 123173-60-4 + 82419-26-9
反应条件:1.1 Reagents: Potassium Hydroxide Solvents: Dmso-D6,Water; 2 H,18 - 20 °C; 6 H,18 - 22 °C1.2 Reagents: Water; 0 - 5 °C1.3 Reagents: Hydrochloric Acid Solvents: Water; 2 H,Ph 1,0 - 5 °C
标题:Synthesis Of Fluorinated Halonitrobenzenes And Halonitrophenols Using Tetrafluoroethylene And Buta-1,3-Dienes As Starting Building Blocks
作者:Volchkov,N. V.; Et Al
参考文献:Russian Chemical Bulletin 日期:2021 卷标:70(11) 页码:2156-2163]

36556-47-5 = 123173-60-4 + 82419-26-9
反应条件:1.1 Reagents: Sulfuric Acid,Fuming Nitric Acid; 1 H,10 - 15 °C; 2 H,15 - 20 °C2.1 Reagents: Potassium Fluoride,1-Chloro-2,3-Difluoro-5-Nitrobenzene,2-Chloro-3,4-Difluoro-1-Nitrobenzene Catalysts: Tetramethylammonium Chloride Solvents: Dmso-D6; 7 H,130 - 135 °C3.1 Reagents: Potassium Hydroxide Solvents: Dmso-D6,Water; 2 H,18 - 20 °C; 6 H,18 - 22 °C3.2 Reagents: Water; 0 - 5 °C3.3 Reagents: Hydrochloric Acid Solvents: Water; 2 H,Ph 1,0 - 5 °C
标题:Synthesis Of Fluorinated Halonitrobenzenes And Halonitrophenols Using Tetrafluoroethylene And Buta-1,3-Dienes As Starting Building Blocks
作者:Volchkov,N. V.; Et Al
参考文献:Russian Chemical Bulletin 日期:2021 卷标:70(11) 页码:2156-2163]

958996-49-1 = 123173-60-4 + 82419-26-9
反应条件:1.1 Reagents: Sodium Hydroxide Catalysts: Benzyltriethylammonium Chloride Solvents: Water; 2 H,25 - 45 °C; 5 H,85 - 95 °C2.1 Reagents: Sulfuric Acid,Fuming Nitric Acid; 1 H,10 - 15 °C; 2 H,15 - 20 °C3.1 Reagents: Potassium Fluoride,1-Chloro-2,3-Difluoro-5-Nitrobenzene,2-Chloro-3,4-Difluoro-1-Nitrobenzene Catalysts: Tetramethylammonium Chloride Solvents: Dmso-D6; 7 H,130 - 135 °C4.1 Reagents: Potassium Hydroxide Solvents: Dmso-D6,Water; 2 H,18 - 20 °C; 6 H,18 - 22 °C4.2 Reagents: Water; 0 - 5 °C4.3 Reagents: Hydrochloric Acid Solvents: Water; 2 H,Ph 1,0 - 5 °C
标题:Synthesis Of Fluorinated Halonitrobenzenes And Halonitrophenols Using Tetrafluoroethylene And Buta-1,3-Dienes As Starting Building Blocks
作者:Volchkov,N. V.; Et Al
参考文献:Russian Chemical Bulletin 日期:2021 卷标:70(11) 页码:2156-2163]

2646-83-5 = 123173-60-4 + 82419-26-9
反应条件:1.1 Reagents: Chlorine Catalysts: Iron Chloride (Fecl3) Solvents: Chloroform; 10 H,25 - 35 °C; 2 H,30 - 35 °C2.1 Reagents: Sodium Hydroxide Catalysts: Benzyltriethylammonium Chloride Solvents: Water; 2 H,25 - 45 °C; 5 H,85 - 95 °C3.1 Reagents: Sulfuric Acid,Fuming Nitric Acid; 1 H,10 - 15 °C; 2 H,15 - 20 °C4.1 Reagents: Potassium Fluoride,1-Chloro-2,3-Difluoro-5-Nitrobenzene,2-Chloro-3,4-Difluoro-1-Nitrobenzene Catalysts: Tetramethylammonium Chloride Solvents: Dmso-D6; 7 H,130 - 135 °C5.1 Reagents: Potassium Hydroxide Solvents: Dmso-D6,Water; 2 H,18 - 20 °C; 6 H,18 - 22 °C5.2 Reagents: Water; 0 - 5 °C5.3 Reagents: Hydrochloric Acid Solvents: Water; 2 H,Ph 1,0 - 5 °C
标题:Synthesis Of Fluorinated Halonitrobenzenes And Halonitrophenols Using Tetrafluoroethylene And Buta-1,3-Dienes As Starting Building Blocks
作者:Volchkov,N. V.; Et Al
参考文献:Russian Chemical Bulletin 日期:2021 卷标:70(11) 页码:2156-2163

2,3-二氟苯酚置于硝酸体系中,用二氯氟甲烷,水用作溶剂,化学反应 0.5H,以29%的收率获得2,3-二氟-4-硝基苯酚
参考文献: Lrrk2 Inhibitors[fr] Inhibiteurs De Lrrk2
标题: Lrrk2 Inhibitors[fr] Inhibiteurs De Lrrk2