CAS: 137553-42-5; 2-Fluoro-4-Iodobenzonitrile

相似化合物

124700-40-9 699016-40-5 141743-50-2

上下游产品

CAS号29632-74-4 2-氟-4-碘苯胺 | CAS号151-50-8 氰化钾

4-氰基-3-氟苯硼酸置于copper(L) Iodide,N-碘吗啉氢碘酸盐体系中,用 甲醇 用作溶剂,化学反应 24.0H,反应生成2-氟-4-碘苯腈
参考文献:一种实用的和一般本位使用的芳基硼酸的碘化ñ-Iodomorpholinium碘(nimi)作为一种新的碘化剂:轻度和区域选择性合成芳基碘的†
标题:一种实用的和一般本位使用的芳基硼酸的碘化ñ-Iodomorpholinium碘(nimi)作为一种新的碘化剂:轻度和区域选择性合成芳基碘的†
摘要:为a温和高效的协议本位的芳基硼酸使用-Iodination ñ-Iodomorpholinium碘(nimi)产生原位从吗啉和分子碘作为一种新型的碘化剂已经研制成功.观测到添加催化量的碘化铜可以促进碘化反应的速率提高,并且取决于硼酸的性质,可以显着提高产率.机理研究表明,取决于基材的性质,经典的ipso取代或铜催化的碘脱硼化途径总体上主导了目前的碘化反应.诸如温和的反应条件,操作简便,高至优异的收率,优异的官能团相容性和较低的催化剂载量等特征使该方法潜在地可用于有机合成中.
Doi:10.1039/c5Ra18820B

专利信息

专利号:AU-2018387110-A1
优先权日:2017-12-19
标题 :Synthesis of the 1 :1 :1 co-crystal of 1 -cyano-2-(4-cyclopropyl-benzyl)-4-(beta-D-glucopyranos-1 -yl)-benzene, L-proline and water

专利号:CN-111511725-B
优先权日:2017-12-19
标 题 :1-cyano-2- (4-cyclopropyl-benzyl) -4-) (beta-D-glucopyranos-1-yl) -benzene Synthesis of 1:1:1 Co-crystals of L-proline and Water

专利号:CA-3085671-A1
优先权日:2017-12-19
标题:Synthesis of the 1:1:1 co-crystal of 1-cyano-2-(4-cyclopropyl-benzyl)-4-(beta-d-glucopyranos-1 -yl)-benzene, l-proline and water

专利号:US-11629161-B2
优先权日:2017-12-19
标 题:Synthesis of 1:1:1 co-crystal of 1-cyano-2-(4-cyclopropyl-benzyl)-4-(ß-d-glucopyranos-1-yl)-benzene, L-proline and water
发明人：ECKHARDT MATTHIAS; BRINK MONIKA; HIMMELSBACH FRANK; SAHLI STEFAN; SHU CHUTIAN; WANG XIAO-JUN; WEBER BEAT THEODOR; YANG BING-SHIOU
权利人:BOEHRINGER INGELHEIM VETMEDICA GMBH
摘要:Intermediate compounds are described herein and which are used to manufacture a crystalline compound 1-cyano-2-(4-cyclopropyl-benzyl)-4-(β-D-glucopyranos-1-yl)-benzene L-proline monohydrate.

专利号:EP-3668846-A1
优先权日:2017-12-19
标 题:Synthesis of the 1 :1 :1 co-crystal of 1 -cyano-2-(4-cyclopropyl-benzyl)-4-(beta-d-glucopyranos-1 -yl)-benzene, l-proline and water

专利号:US-2021139520-A1
优先权日:2017-12-19
标题 :SYNTHESIS OF 1:1:1 CO-CRYSTAL OF 1-CYANO-2-(4-CYCLOPROPYL-BENZYL)-4-(ß-D-GLUCOPYRANOS-1-YL)-BENZENE, L-PROLINE AND WATER