CAS: 15788-16-6; 1H-Benzo[d]Imidazole-5-Carboxylic Acid

该化合物是一种环状有机化合物,其特点是其复方氨基核心结构,包括一个诱导苯乙烯和imidazole环.该化合物的特点是在双方氨酸环的5位置上有一个箱状酸功能组(-COOH),这增加了其酸性能.它通常是白到白的晶体状固体,在水和酒精等极地溶剂中溶解.该化合物可能展示生物活动,使其对药物研究感兴趣,特别是它在各种治疗剂的开发中的作用.该化合物的化学特性包括标准条件下的中度稳定性,它可能参与各种典型的箱状酸化学反应,例如化和恐吓.此外,在复方氨醇结构中存在氮原子可以促进与金属离子的协调,这可能会提高其在化学和催化过程中的效用.

结构式图片

相似化合物

6287-83-8 26663-77-4 58442-17-4

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

苯并咪唑-5-羧酸甲酯 Methyl 1H-Benzo[d]Imidazole-5-Carboxylate 26663-77-4
5-甲基苯并咪唑 5-Methylbenzimidazole 614-97-1
2-(2,4-Dichloro-Phenoxymethyl)-1H-Benzoimidazole-5-Carboxylic Acid Methyl Ester 1000887-91-1

合成工艺路线路线简述

    5-甲基苯并咪唑置于potassium Permanganate体系中,化学反应生成1H-苯并咪唑-5-羧酸
    参考文献:Studies On The Antitubercular Compounds. Xiii. Preparation Of Some Derivatives Of Benzimidazole And 2,1,3-Benzothiadiazole
    标题:Studies On The Antitubercular Compounds. Xiii. Preparation Of Some Derivatives Of Benzimidazole And 2,1,3-Benzothiadiazole
    摘要:
    Doi:10.1246/bcsj.31.252

    海关参考信息

    专利信息


    专利号:US-2010279122-A1
    优先权日:2006-08-16
    标题:Benzimidazole, Benzoxazole and Benzothiazole Derivatives, Optical Film Comprising them and Method of Producing thereof
    发明人:NOKEL ALEXEY; LAZAREV PAVEL I
    权利人:CRYSOPTIX KK
    摘要:The present invention is relates to the synthesis of predominantly planar heterocyclic organic compound and the manufacture of optical films based on these compounds. Said organic compound has the general structural formula where Het is a predominantly planar heterocyclic molecular system possessing hydrophilic properties; B is a binding group; p is the number in the range from 3 to 8; S is a group providing solubility of the organic compound; m is a number in the range from 0 to 8. Said organic compound is transparent for electromagnetic radiation in the visible spectral range from 400 to 700 nm, and a solution of the compound or a salt thereof is capable of forming a substantially transparent optical layer on a substrate, with the heterocyclic molecular planes oriented predominantly parallel to the substrate surface.

    专利号:US-9574189-B2
    优先权日:2005-12-01
    标题:Enzymatic encoding methods for efficient synthesis of large libraries
    发明人:FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK
    权利人:FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK; NUEVOLUTION AS
    摘要:Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).

    专利号:US-2003092064-A1
    优先权日:2001-04-05
    标题 :System for the synthesis of spatially separated libraries of compounds and methods for the use thereof
    发明人:READER JOHN C
    权利人:MILLENNIUM PHARM INC
    摘要:Featured is an apparatus useful for preparing combinatorial libraries of compounds in a parallel fashion so that the individual compounds of the library are spatially separate and the position of each compound of the library in the apparatus is known. Moreover, the apparatus is useful for the preparation of combinatorial libraries of compounds where the library is constructed from three or more building blocks, e.g., three, four, five, six or seven building blocks, resulting in a three, four, five, six or seven dimensional combinatorial library. Also featured are related methods for the preparation of three, four, five, six or seven dimensional combinatorial libraries of compounds using the apparatus of the present invention.

    专利号:US-6531470-B1
    优先权日:1998-01-23
    标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
    发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
    权利人:UPJOHN CO
    摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

    专利号:US-11702652-B2
    优先权日:2005-12-01
    标题:Enzymatic encoding methods for efficient synthesis of large libraries

    专利号:US-2009264300-A1
    优先权日:2005-12-01
    标题 :Enzymatic encoding methods for efficient synthesis of large libraries
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    合成参考文献


    参考文献:10.1007/s10895-006-0083-y
    摘要:Yan B, Wang WJ, Song YS. Double fluorescence conversion in ultraviolet and visible region for some praseodymium complexes of aromatic carboxylates. J Fluoresc. 2006 Jul;16(4):495–500. doi: 10.1007/s10895-006-0083-y.
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