CAS: 2026-48-4; (S)-2-Amino-3-Methylbutan-1-Ol

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2-溴代异戊酸置于palladium On Activated Charcoal 盐酸,Lithium Aluminium Tetrahydride,硫酸,氢气,Sodium Carbonate体系中,用 甲醇,乙醚,乙醇 用作溶剂,化学反应 21.0H,反应生成L-缬氨醇
参考文献:Asymmetric .Alpha.-Substituted Phenethylamines. I. Synthesis Of Optically Pure 1-Aryl-N-(2'-Hydroxy-1'-Isopropylethyl)-2-Phenylethylamines.
标题:Asymmetric .Alpha.-Substituted Phenethylamines. I. Synthesis Of Optically Pure 1-Aryl-N-(2'-Hydroxy-1'-Isopropylethyl)-2-Phenylethylamines.
摘要:通过n-(2-羟基-1-异丙基乙基)苯亚甲基胺(2A-C)与苄基氯化镁的反应,合成了光学纯的1-芳基-N-(2'-羟基-1'-异丙基乙基)-2-苯乙胺(3A-C).通过n-(2-羟基-1-异丙基乙基)苯乙亚甲基胺(4)与芳基锂化合物的反应,制备了非对映异构体(5A-C).通过另一条合成路线阐明了3A的光学纯度,并确定了其绝对构型.核磁共振(NMR)谱中特征的甲基信号表明了手性胺(3A-C和5A-C)的构型.
Doi:10.1248/cpb.30.3160

专利信息

专利号:US-7323575-B2
优先权日:2003-04-09
标题:Process for the synthesis of (2S)-indoline-2-carboxylic acid
发明人：SOUVIE JEAN-CLAUDE; LECOUVE JEAN-PIERRE
权利人:SERVIER LAB
摘要:Process for the synthesis of (2S)-indoline-2-carboxylic acid of formula (I): n nApplication in the synthesis of perindopril and its pharmaceutically acceptable salts.

专利号:US-10040752-B2
优先权日:2015-08-24
标 题 :Synthesis of levomethadone hydrochloride or dextromethadone hydrochloride and methods for use thereof
发明人：MKRTCHYAN GNEL; YAO QINGWEI
权利人:CODY LABORATORIES INC
摘要:Highly efficient methods for synthesis of levomethadone hydrochloride or dextromethadone hydrochloride are provided starting from D-alanine, or L-alanine, respectively, with retention of configuration. Methods for treating a subject are provided comprising administering a composition comprising an effective amount of levomethadone hydrochloride having not more than 10 ppm dextromethadone.

专利号:WO-2025101716-A1
优先权日:2023-11-07
标题:Processes for synthesis of trifunctionalized sulfur(vi) compounds
发明人：LOPCHUK JUSTIN; SHULTZ ZACHARY; ATHAWALE PARESH
权利人:H LEE MOFFITT CANCER CT & RES
摘要:This disclosure describes processes for the asymmetric synthesis of trifunctionalized sulfur(VI) containing organic compounds of Formula I and Formula VI, as well as compounds of Formula I and Formula VI prepared by the processes described.

专利号:US-5869725-A
优先权日:1994-05-17
标 题:Derivatives of aminosulfonic acids, utilization of the same in the synthesis of pseudopeptides and process for their preparation
发明人：GENNARI CESARE; POTENZA DONATELLA; SALOM BARBARA
权利人:PHARMACIA & UPJOHN SPA
摘要:Derivatives of gamma-amino-alpha,beta-unsaturated sulfonic acids, a process for the preparation of the same and their utilization in the synthesis of pseudopeptides characterized by the presence of at least a sulfonamide type bond conjugated to a double bond are described.

专利号:US-9206222-B2
优先权日:2009-06-29
标题:Solid phase peptide synthesis of peptide alcohols
发明人：CAUSSIL-AMBLARD MURIEL; MARTINEZ JEAN; TAILHADES JULIEN
权利人:CAUSSIL-AMBLARD MURIEL; MARTINEZ JEAN; TAILHADES JULIEN; CENTRE NAT RECH SCIENT
摘要:The present invention relates to the synthesis of depsipeptides on solid phase support. Said depsipeptides are then implicated in a solution phase O—N acyl shift enabling to obtain the corresponding peptide alcohols.

专利号:US-11414367-B2
优先权日:2020-11-10
标题:Method of preparing and method of using tetracarbonyl cyclobutene dihydrate compound
发明人：LUO MEI
权利人:INTELLIGENT MANUFACTURING TECHNOLOGY RESEARCH INSTITUTE HEFEI UNIV OF TECHNOLOGY; INIELLIGENT MANUFACTURING TECHNOLOGY RESEARCH INSTITUTE HEFEI UNIV OF TECHNOLOGY
摘要:A tetracarbonyl cyclobutene dihydrate compound, having a chemical formula (I). n n n n n n n n n n A method of synthesizing the tetracarbonyl cyclobutene dihydrate compound, includes: a synthesis step, a separation step, and a purification step. The synthesis step includes: collecting and dissolving 0.5728 g of squaric acid, 2.7948 g of ammonium formate, and 0.0480 g of the palladium complex in 100 mL of anhydrous methanol, heating and stirring a resulting mixture to reflux for 48 hrs, and stopping the reaction. The separation step includes: performing column chromatography analysis on reaction products according to a volume ratio of dichloromethane to anhydrous methanol of 8:2, to obtain a target product. A method of using the tetracarbonyl cyclobutene dihydrate compound, includes: using tetracarbonyl cyclobutene dihydrate compound as a catalyst in addition reaction between ethyl pyruvate and nitromethane, where a conversion rate of ethyl pyruvate reaches 96.1%.