CAS: 20325-40-0; 3,3'-Dimethoxybenzidine Dihydrochloride

专利信息

专利号:WO-9930730-A1
优先权日:1997-12-15
标题:Methods and compositions for improving the success of cell transplantation in a host
发明人：TREMBLAY JACQUES P
权利人:UNIV LAVAL; TREMBLAY JACQUES P
摘要:The present invention covers significant improvements for each event involved in the transplantation success or graft survival. These improvements, separately or combined with each other, greatly ameliorate the recovery of a tissue towards a normal function. They comprise: a) the reduction of early death of transplanted cells by anti-inflammatory agents such as TGFbeta1, an inhibitor of oligosaccharide synthesis, a glucosidase, IL-10, vIL-10, IL-4, INFgamma, IL-2R, IL-1Ra, Fas-L, sCR1, a super oxide dismutase, a neutrophil inhibitory factor (NIF), a ligand binding in an antagonist fashion to LFA-1, MAC-1, ICAM-1, CD-18, CD-31, CD-50, E-selectin, P-selectin, TNFalpha, IL-1 and IL-8. The anti-inflammatory agents may comprise an anti-LFA-1 or -ICAM-1; b) the improvement of the diffusion and of the fusion of transplanted cells with the host tissue by metalloproteases; c) the ex vivo proliferation of the transplanted cells with growth factors or oncogenes; d) the use of fibroblasts or stem cells in lieu of myoblasts, by transforming the formers into the latter with myogenic genes; e) expressing utrophin in lieu of dystrophin in cases of muscular dystrophy; and e) immunosuppressing the host for long-term graft survival.