CAS: 24473-00-5; 2,4,6-Trichlorobenzaldehyde

该化合物是一种芳香化合物,其特点是苯甲醚功能组和三种氯替代物存在于苯环的2,4和6个位置上.该化合物一般是无色的,可粉色黄色,具有独特的杏仁类味,具有苯甲醚衍生物的特征.该化合物在有机合成中的应用,特别是作为各种药品和农用化学品生产的中间体.氯原子的存在增强了其再活动性,使其在电子替代反应中有用.此外,2,4,6-三氯苯甲醚在有机溶剂中表现出中等溶性,水溶性有限,氯化芳烃化合物常见.安全考虑非常重要,因为接触时可能会对健康造成危害,因此需要适当的处理和储存规程.

结构式图片

上下游产品

CAS号108-70-3 均三氯苯 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号6575-05-9 2,4,6-三氯苯甲腈 | CAS号217479-60-2 2,4,6-三氯苯甲醇 | CAS号23749-65-7 1,3,5-trichloro... | CAS号88-06-2 2,4,6-三氯苯酚 | CAS号28744-45-8 2,4,6-Trichloro... | CAS号24473-01-6 3,3-dimethyl-1-... | CAS号108-70-3 均三氯苯 | CAS号64-18-6 甲酸 | CAS号88176-57-2 5-(2,4,6-trichl... | CAS号885519-58-4 4,6-二氯吲唑

合成工艺路线路线简述

    2,4,6-三氯苯酚置于potassium Carbonate体系中,用 丙酮 用作溶剂,化学反应生成2,4,6-三氯苯甲醛
    参考文献:Bisagni,E.; Rivalle,C.,Bulletin De La Societe Chimique De France,1969,P. 3111-3115
    标题:Bisagni,E.; Rivalle,C.,Bulletin De La Societe Chimique De France,1969,P. 3111-3115

    海关参考信息

    专利信息


    专利号:US-2009306400-A1
    优先权日:2006-03-27
    标 题:Convergent process for the synthesis of taxane derivatives.
    发明人:HENRI JOHN T; MCCHESNEY JAMES D; VENKATARAMAN SYLESH K; LAMB RODGER L; FOSTER JONATHAN E; SUMNER CHRISTIAN M; YE SHANGPING
    权利人:HENRI JOHN T; MCCHESNEY JAMES D; VENKATARAMAN SYLESH K; LAMB RODGER L; FOSTER JONATHAN E; SUMNER CHRISTIAN M; YE SHANGPING
    摘要:The present invention is broadly directed to novel compounds useful for the synthesis of biologically active compounds, including taxane derivatives, and convergent processes for the preparation of these taxane derivatives and their intermediates.

    专利号:US-9597327-B2
    优先权日:2005-05-25
    标 题:Synthesis of (R)-N-methylnaltrexone
    发明人:DOSHAN HAROLD D; PEREZ JULIO
    权利人:PROGENICS PHARM INC
    摘要:This invention relates to stereoselective synthesis of R-MNTX and intermediates thereof, pharmaceutical preparations comprising R-MNTX or intermediates thereof and methods for their use.

    专利号:US-7153957-B2
    优先权日:2003-08-07
    标 题:Regioselective synthesis of CCI-779
    发明人:CHEW WARREN; SHAW CHIA-CHENG
    权利人:WYETH CORP
    摘要:A method for regioselective synthesis of CCl-779 based on boronate chemistry is provided. Also provided are novel intermediates useful in this method.

    专利号:US-9303056-B2
    优先权日:2012-07-25
    标题 :Monomer for synthesis of RNA, method for producing same, and method for producing RNA
    发明人:KATAOKA MASANORI
    权利人:UNIV KOCHI
    摘要:The objective of the present invention is to provide a monomer for RNA synthesis which can be efficiently produced and therefore by which the producing cost of RNA can be remarkably decreased, and a method for efficiently producing the monomer in a small number of steps. In addition, the objective of the present invention is also to provide a method by which RNA can be efficiently produced even when a approximately stoichiometry amount of the monomer for RNA synthesis is used. The monomer for RNA synthesis according to the present invention is represented by the following formula (I) or (I′): n nwherein R 1 is a protective group of the hydroxy group and R 2 is an alkyl group or the like.

    专利号:US-2024132460-A1
    优先权日:2021-03-10
    标题:Synthesis of tigilanol tiglate and analogs thereof
    发明人:WENDER PAUL A; LUU NGUYEN HONG QUANG; GENTRY ZACHARY; NJOO EDWARD; FANELLI DAVID; MCATEER OWEN DENNIS
    权利人:UNIV LELAND STANFORD JUNIOR
    摘要:Provided are methods for the isolation of phorbol from seed sources and the use of the phorbol for the generation of tigliane tiglate and derivatives thereof.

    专利号:EP-1216251-B1
    优先权日:1999-09-29
    标题 :Regioselective synthesis of rapamycin derivatives
    发明人:SHAW CHIA-CHENG; SELLSTEDT JOHN HAMILTON; NOURELDIN RAZZAK; CHEAL GLORIA KAREN; FORTIER GENEVIEVE
    权利人:WYETH CORP
    摘要:This invention provides a regioselective process for preparing a 42-ester or ether of rapamycin, and 31-silyl ether intermediates.
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    合成参考文献


    参考文献:10.1055/s-0034-1378737
    摘要:Sammelson R, Miller D, Bailey C. Synthesis of Isoxazolines and Isoxazoles Inspired by Fipronil. Synthesis. 2015 Jul 29;47(18):2791–8. doi: 10.1055/s-0034-1378737.
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