2,4,6-三甲基吡啶置于水,硝酸体系中,化学反应生成 2,6-二甲基-4-吡啶甲酸 参考文献:Lukes; Galik,Collection Of Czechoslovak Chemical Communications,1958,Vol. 23,P. 1083,1087 标题:Lukes; Galik,Collection Of Czechoslovak Chemical Communications,1958,Vol. 23,P. 1083,1087
专利号:US-2008058528-A1 优先权日:2006-07-20 标题 :Synthesis of (2S,5R)-5-ethynyl-1-{N-(4-methyl-1-(4-carboxy-pyridin-2-yl)piperidin-4-yl)glycyl}pyrrolidine-2-carbonitrile
专利号:US-2016152600-A1 优先权日:2006-07-20 标题 :Synthesis of (2s,5r)-5-ethynyl-1-pyrrolidine-2-carbonitrile
专利号:US-9260411-B2 优先权日:2006-07-20 标 题 :Synthesis of (2S,5R)-5-ethynyl-1-{N-(4-methyl-1-(4-carboxy-pyridin-2-yl)piperidin-4-yl)glycyl}pyrrolidine-2-carbonitrile 发明人:MCDERMOTT TODD S; WAGAW SEBLE H; ENGSTROM KENNETH M; GANDARILLA JORGE; KRUGER ALBERT; ROZEMA MICHAEL J; FICKES MICHAEL G; WITTENBERGER STEVEN J; BHAGAVATULA LAKSHMI; BORCHARDT THOMAS B 权利人:MCDERMOTT TODD S; WAGAW SEBLE H; ENGSTROM KENNETH M; GANDARILLA JORGE; KRUGER ALBERT; ROZEMA MICHAEL J; FICKES MICHAEL G; WITTENBERGER STEVEN J; BHAGAVATULA LAKSHMI; BORCHARDT THOMAS B; ABBVIE INC 摘要:A process for making (2S,5R)-5-ethynyl-1-{N-(4-methyl-1-(4-carboxy-pyridin-2-yl)piperidin-4-yl)glycyl}pyrrolidine-2-carbonitrile and salts thereof, and intermediates used in the process are disclosed.
参考文献:10.1177/1087057116635503 摘要:Voter AF, Manthei KA, Keck JL. A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. J Biomol Screen. 2016 Jul;21(6):626–33.