CAS: 6186-22-7; 4-Bromophenylacetone

该化合物是一种有机化合物,其特征是存在一个联苯组的溴原子,该化合物与一个碳酸盐协会有进一步的联系;该化合物通常显示一种白色到浅黄色晶状,以其在有机合成中的作用而著称,特别是在形成各种衍生物和中间体方面;溴代二苯乙酸酯可增强其反应性,使其在电子嗜好替代反应中有用;此外,4-溴联苯乙酸酯在乙醇和丙酮等有机溶剂中可能表现出中等溶性,而由于其湿性很强的联苯基联苯酯组而水中溶性较低;其化学特性包括能够进行核分裂替代并参与各种组合反应,这对合成药物和农业化学物十分宝贵;在处理该化合物时,应注意安全防范措施,因为如果摄入或吸入,可能会对健康造成危害;应使用适当的个人防护设备.

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合成工艺路线路线简述

    4-溴苯胺置于4-氨基吗啉,Sodium Nitrite体系中,用 水,二甲基亚砜,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 12.67H,反应生成 4-溴苯基丙酮
    参考文献:A Family Of Low Molecular-Weight,Organic Catalysts For Reductive C-c Bond Formation
    标题:A Family Of Low Molecular-Weight,Organic Catalysts For Reductive C-c Bond Formation
    摘要:仅使用少量的联氨催化剂,就实现了重氮盐与各种反应性伙伴的偶联,而无需金属辅助剂或可见光或紫外光辐射的要求.
    DOI:10.1039/c5Cc03580E

    海关参考信息

    专利信息


    专利号:EP-1075534-B8
    优先权日:1998-03-11
    标 题 :Improvements in the enzymatic synthesis of chiral amines
    发明人:WU WEI; BHATIA MOHIT B; LEWIS CRAIG M; LANG WEI; WANG ALICE; MATCHAM GEORGE W
    权利人:CELGRO
    摘要:2-Aminopropane is used as the amine donor in the stereoselective synthesis of a chiral amine from a ketone with a transaminase. In a typical embodiment, (S)-1-methoxy-2-aminopropane is prepared by bringing methoxyacetone into contact with a transaminase in the presence of 2-aminopropane as an amine donor until a substantial amount of methoxyacetone is converted to (S)-1-methoxy-2-aminopropane and 2-aminopropane is converted to acetone. In a second embodiment, L-alanine is prepared by bringing pyruvic acid into contact with a transaminase in the presence of 2-aminopropane as an amine donor.

    专利号:US-11401240-B2
    优先权日:2018-11-08
    标 题:Process for the synthesis of lactams
    发明人:DAWKINS DAVID ANTHONY; KOTSAKIS PANAGIOTIS; PARRY NEIL JAMES; THORNTHWAITE DAVID WILLIAM
    权利人:CONOPCO INC
    摘要:A process for the synthesis of lactams suitable for use in antimicrobial, anti-biofilm and bacteriostatic compositions.

    专利号:US-10377707-B2
    优先权日:2015-08-20
    标 题:Process for the preparation of lactams from glyoxalic acid
    发明人:NORBURY ANDREW MARTYN; THORNTHWAITE DAVID WILLIAM
    权利人:CONOPCO INC
    摘要:A process for the synthesis of lactams suitable for use in antimicrobial, anti-biofilm bacteriostatic compositions.

    专利号:US-7750135-B2
    优先权日:2006-07-28
    标题:Molecular design of thermostable alcohol dehydrogenase for synthesis for chiral aromatic alcohols
    发明人:ZEIKUS J GREGORY; ZIEGELMANN-FJELD KARLA I; VIEILLE CLAIRE
    权利人:UNIV MICHIGAN STATE
    摘要:The present invention relates to compositions and methods utilizing thermostable and novel alcohol dehydrogenase enzymes for biosynthesizing chiral specific molecules for use as precursor molecules in synthesizing pharmaceutical compounds. Particularly, in preferred embodiments, the invention relates to directed engineering of an enzymatic catalytic site of an alcohol dehydrogenase enzyme gene for enhancing enantioselectivity for (S)-enantiomer substrate catalytic activity for providing aryl (S)-enantiomer products in stereomeric excess.

    专利号:JP-5021626-B2
    优先权日:2005-04-28
    标 题:Synthesis of phenyl-substituted polyfluoranthene and its use

    专利号:BR-112018003067-B1
    优先权日:2015-08-20
    标 题 :PROCESS FOR THE SYNTHESIS OF A LACTAM
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    合成参考文献


    摘要:Wang, K.; Wang, J., Science of Synthesis, (2022) , 4.
    摘要:Kleemann A., Kutscher B., Reichert D., Bossart M., Pharmaceutical Substances, Thieme [Online], Stuttgart, (2025).
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