CAS: 6892-68-8; Trans-1,4-Dimercaptobutane-2,3-Diol

相似化合物

16096-97-2 3483-12-3 96-27-5

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CAS号40227-25-6 trans-4,5-dihyd... | CAS号930-22-3 3,4-环氧-1-丁烯 | CAS号564-00-1 内消旋-1,2:3,4-二环氧丁烷

1,4-Diacetylthio-2,3-Diacetoxybutane 在 盐酸体系中,用 甲醇作为反应溶剂,反应 5.0H,以70%的收率获得1,4-Dithio-Erythritol
参考文献:用于合成二硫代赤藓醇的中间化合物及其应 用和二硫代赤藓醇的合成方法
标题:用于合成二硫代赤藓醇的中间化合物及其应 用和二硫代赤藓醇的合成方法
摘要:本发明公开了一种用于合成二硫代赤藓醇的中间化合物及其应用和二硫代赤藓醇的合成方法,该中间化合物为2,3‑二乙酰基硫代甲基环氧乙烷,且该中间化合物的化学式为:其可通过将2,3‑二溴甲基环氧乙烷和硫代乙酸盐进行取代反应来制备.二硫代赤藓醇的合成方法包括:将该中间化合物进行水解反应.通过2,3‑二乙酰基硫代甲基环氧乙烷可直接水解得到二硫代赤藓醇,且2,3‑二乙酰基硫代甲基环氧乙烷的制备较简单,为二硫代赤藓醇的合成提供了一种新的合成思路,并且合成路线简短,操作简便,收率较高.

专利信息

专利号:US-7041479-B2
优先权日:2000-09-06
标题 :Enhanced in vitro synthesis of active proteins containing disulfide bonds
发明人：SWARTZ JAMES ROBERT; KIM DONG-MYUNG
权利人:TRUSTESS OF THE LELAND STANFOR
摘要:Compositions and methods are provided for the enhanced in vitro synthesis of polypeptides containing disulfide bonds. In order to improve the performance of in vitro protein synthesis reactions, pre-treatment and redox buffering of the reaction mix is performed in order to optimize the redox potential. Exogenous enzymes that enhance protein folding and disulfide bond formation may also be added to the reaction.

专利号:US-6548276-B2
优先权日:2000-09-06
标题:Enhanced in vitro synthesis of active proteins containing disulfide bonds
发明人：SWARTZ JAMES ROBERT; KIM DONG-MYUNG
权利人:UNIV LELAND STANFORD JUNIOR
摘要:Compositions and methods are provided for the enhanced in vitro synthesis of polypeptides containing disulfide bonds. In order to improve the performance of in vitro protein synthesis reactions, pre-treatment and redox buffering of the reaction mix is performed in order to optimize the redox potential. Exogenous enzymes that enhance protein folding and disulfide bond formation may also be added to the reaction.

专利号:US-6040423-A
优先权日:1990-08-31
标题 :Process for synthesis of peptides
发明人：FRANK RONALD; GULER SINAN
权利人:BIOTECHNOLOG FORSCHUNG GMBH
摘要:The invention relates to a process for the rapid synthesis of support-bound or free peptides, a device for carrying out the process, a flat material with peptides bound to it which are prepared according to the process, and to a use for the flat material.

专利号:US-5352670-A
优先权日:1991-06-10
标题:Methods for the enzymatic synthesis of alpha-sialylated oligosaccharide glycosides
发明人：VENOT ANDRE P; UNGER FRANK M; KASHEM MOHAMMED A; BIRD PAUL; MAZID M ABDUL
权利人:ALBERTA RES COUNCIL
摘要:Disclosed are methods for the enzymatic synthesis of alpha-sialylated oligosaccharide glycosides. Specifically, in the disclosed methods, sialyltransferase is activated to transfer an analogue of sialic acid, employed as its CMP-nucleotide derivative, to an oligosaccharide glycoside. The analogue of sialic acid and the oligosaccharide employed in this method are selected to be compatible with the sialyltransferase employed.

专利号:US-5043328-A
优先权日:1986-05-09
标 题 :Formulations containing unsaturated fatty acids for the synthesis of prostaglandins and hydroxy-fatty acids in biological systems
发明人：WEITHMANN KLAUS U
权利人:HOECHST AG
摘要:The present invention relates to formulations containing unsaturated fatty acids for the synthesis of prostaglandins and hydroxy-fatty acids in biological systems and to the use of such formulations for the preparation of medicaments which are suitable for curing prostaglandin deficiencies in humans or animal, for example healing or preventing diseases of the gastro-intestinal tract.

专利号:WO-2017100796-A1
优先权日:2015-12-11
标 题 :Modulation of globoseries glycosphingolipid synthesis and cancer biomarkers
发明人：WONG CHI-HUEY; HSU TSUI-LING; WU CHUNG-YI; CHEUNG SARAH K C; CHUANG PO-KAI
权利人:SINACA ACAD; WONG CHI-HUEY; HSU TSUI-LING
摘要:The present disclosure relates to methods and compositions which can modulate the globoseries glycosphingolipid synthesis. Particularly, the present disclosure is directed to glycoenzyme inhibitor compound and compositions and methods of use thereof that can modulate the synthesis of globoseries glycosphingolipid SSEA-3/SSEA-4/GloboH in the biosynthetic pathway; particularly, the glycoenzyme inhibitors target the alpha-4GalT; beta- 4GalNAcT-I; or beta-3GalT-V enzymes in the globoseries synthetic pathway. Additionally, the present disclosure is also directed to vaccines, antibodies, and/or immunogenic conjugate compositions targeting the SSEA-3/SSEA-4/GLOBO H associated epitopes (natural and modified) which elicit antibodies and/or binding fragment production useful for modulating the globoseries glycosphingolipid synthesis. Moreover, the present disclosure is also directed to the method of using the compositions described herein for the treatment or detection of hyperproliferative diseases and/or conditions. Furthermore, the instant disclosure also relates to cancer stem cell biomarkers for disgnostic and therapeutic uses.