CAS: 698-29-3; 4-Amino-2-Methylpyrimidine-5-Carbonitrile

相似化合物

769-52-8 73-68-7 73-70-1

上下游产品

CAS号38238-93-6 2-(diethylamino... | CAS号124-42-5 乙脒盐酸盐 | CAS号14777-27-6 甲基乙酰亚胺酯 盐酸盐 | CAS号672-25-3 Propanedinitril... | CAS号86843-46-1 2,2-dicyanoviny... | CAS号16849-88-0 二甲胺亚甲基丙二腈 | CAS号56563-10-1 4-amino-2-methy... | CAS号143-37-3 acetamidine | CAS号123-06-8 乙氧基亚甲基丙二腈 | CAS号5472-46-8 2-甲基-4-氨基-5-嘧啶甲酸乙酯 | CAS号1886-34-6 N-((4-氨基-2甲基嘧啶-... | CAS号108482-83-3 (4-amino-2-meth... | CAS号74-69-1 2-甲基-4-氨基嘧啶 | CAS号73-67-6 4-氨基-2-甲基-5-嘧啶甲醇 | CAS号73-68-7 4-氨基-2-甲基嘧啶-5-甲醛 | CAS号95-02-3 4-氨基-5-氨甲基-2-甲基嘧啶 | CAS号31375-20-9 N-[(4-amino-2-m... | CAS号120208-35-7 7-甲基嘧啶并[4,5-d]嘧... | CAS号70-16-6 维生素b1

4,6-二羟基-2-甲基嘧啶置于甲醇,Potassium Cyanate,Lindlar'S Catalyst,氨,三氯氧磷体系中,化学反应生成 2-甲基-4-氨基嘧啶-5-腈
参考文献:Budesinsky; Kopecky,Collection Of Czechoslovak Chemical Communications,1955,Vol. 20,P. 52,56
标题:Budesinsky; Kopecky,Collection Of Czechoslovak Chemical Communications,1955,Vol. 20,P. 52,56

专利信息

专利号:WO-2011116933-A1
优先权日:2010-03-24
标 题 :Process for the preparation of 2-substituted 4-amino-5-cyanopyrimidines
发明人：DICK VIKTOR; HANSELMANN PAUL; KRAMER RAINER; LADNAK VIKTOR
权利人:LONZA AG; DICK VIKTOR; HANSELMANN PAUL; KRAMER RAINER; LADNAK VIKTOR
摘要:A compound of the formula (I), wherein R 1 is C 1-4 alkyl or phenyl, is prepared by reacting a dicyanomethanide of the formula: M r n + [CH(CN) 2 ] rÌ… n (II), wherein M is an alkali or alkaline earth metal and r is 1 or 2, with carbon monoxide to obtain a dicyanoethenolate of the formula: M r n + [(NC) 2 C=CH–O] rÌ… (III), which is acylated to obtain an acyloxymethylenemalononitrile of the formula: (NC) 2 C=CH–OCOR 2 (IV), wherein R 2 is C 1-4 alkyl, which in turn is reacted with an amidine of the formula (V) to obtain the 4-amino-5-cyanopyrimidine of the formula (I). The compound of formula (I), wherein R is methyl, is an intermediate in a synthesis of thiamin (vitamin B 1 ).

专利号:US-3853946-A
优先权日:1971-11-11
标题 :Process for the preparation of aminomethylene malononitrile
发明人：LEIMGRUBER W; WEIGELE M
权利人:HOFFMANN LA ROCHE
摘要:This invention is directed to a process for the preparation of aminomethylene malononitrile from dialkyl aminoacylonitrile including intermediates therein. Aminomethylene malononitrile is a known compound which is a valuable intermediate in the synthesis of thiamine.

专利号:US-3900511-A
优先权日:1973-03-05
标 题 :Process for the preparation of aminomethylene malononitrile
发明人：LEIMGRUBER WILLY; WEIGELE MANFRED
权利人:HOFFMANN LA ROCHE
摘要:This invention is directed to a process for the preparation of aminomethylene malononitrile from dialkyl aminoacylonitrile including intermediates therein. Aminomethylene malononitrile is a known compound which is a valuable intermediate in the synthesis of thiamine.

专利号:US-3742015-A
优先权日:1968-04-09
标题:Process for the preparation of aminomethylene malononitrile
发明人：LEIMGRUBER W; WEIGELE M
权利人:HOFFMANN LA ROCHE
摘要:This invention is directed to a process for the preparation of aminomethylene malononitrile from dialkyl aminoacrylonitrile including intermediates therein. Aminomethylene malononitrile is a known compound which is a valuable intermediate in the synthesis of thiamine.

专利号:US-7060818-B2
优先权日:2003-02-21
标题:Synthesis of macrocyclic tetraamido compounds and new metal insertion process
发明人：HORWITZ COLIN P; GHOSH ANINDYA
权利人:UNIV CARNEGIE MELLON
摘要:An improved method of synthesizing a macrocyclic tetraamido compound includes protecting the amino portion of an amino carboxylic acid to form a protected amino carboxylic acid; exposing the protected amino carboxylic acid to a first solvent, preferably a hydrocarbon solvent, such as toluene or 1,2-dichloroethane, dichloromethane, dibromomethane and 1,2-dibromoethane. The carboxylic acid portion of the protected amino carboxylic acid is then converted to an activated carboxylic acid by one of esterification or acid halide formation, to form a protected amino activated carboxylic acid derivative. The protected amino activated carboxylic acid derivative is reacted with a diamine in the presence of a second solvent, such as THF or ,2-dichloroethane, dichloromethane, dibromomethane and 1,2-dibromoethane, to form a protected diamide diamine intermediate. Following deprotection, the diamide diamine intermediate is reacted with an activated diacid, such as an activated malonate, oxalate or succinate derivative to form the macrocyclic tetraamido compound. The macrocyclic tetraamido compound may further be complexed with a transition metal.

专利号:US-2004167329-A1
优先权日:2003-02-21
标 题:Synthesis of macrocyclic tetraamido compounds and new metal insertion process