CAS: 89-60-1; 1-Chloro-4-Methyl-2-Nitrobenzene

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CAS号89-62-3 4-甲基-2-硝基苯胺 | CAS号106-43-4 对氯甲苯 | CAS号75508-74-6 5-chloro-2-meth... | CAS号108-24-7 乙酸酐 | CAS号108-88-3 甲苯 | CAS号7697-37-2 硝酸 | CAS号7664-93-9 硫酸 | CAS号3622-31-9 2-氯-5-甲基苯并噻唑 | CAS号40925-61-9 5-甲基苯并[D]噻唑-2(3H)-酮 | CAS号941294-27-5 7-氯-4-甲基吲哚 | CAS号21303-50-4 5-甲基-2-巯基苯并噻唑 | CAS号2172-91-0 5-甲基-2-苯氧基苯胺 | CAS号35350-31-3 2-硝基对甲苯基二硫化物 | CAS号14371-80-3 3-nitro-4-merca... | CAS号27329-27-7 4-甲基-2-硝基苯甲酸 | CAS号98-88-4 苯甲酰氯 | CAS号96-99-1 4-氯-3-硝基苯甲酸

4-甲基-2-硝基苯甲酸置于新铜试剂,氧气,Copper Diacetate,Silver Sulfate,Sodium Chloride体系中,用 二甲基亚砜 作为反应溶剂,160.0 °C,101.33 Kpa 条件下,反应 20.0H,以51%的收率获得产物3-硝基-4-氯甲苯
参考文献:廉价的nax(x = I,Br,Cl)作为有氧条件下实际的ag / Cu介导的芳基羧酸脱羧卤化反应中的卤素供体†
标题:廉价的nax(x = I,Br,Cl)作为有氧条件下实际的ag / Cu介导的芳基羧酸脱羧卤化反应中的卤素供体†
摘要:在好氧条件下,中等到非常好的收率已经实现了易于获得的芳基羧酸与丰富的nax(x = I,Br,Cl)之间的多功能且实用的ag / Cu介导的脱羧卤化反应.对于在邻位具有硝基,氯和甲氧基取代基的含s的杂芳族羧酸和苯甲酸,表明卤代羧化是一种有效的策略.已经进行了克级反应和三步合成iniparib的过程,以评估该协议的实用性.初步的机械研究表明,Cu起着至关重要的作用,并且自由基途径参与了转变.
DOI:10.1039/c8Ob01095A

专利信息

专利号:EP-2173747-B1
优先权日:2007-06-26
标 题:A regioselective metal catalyzed synthesis of annelated benzimidazoles and azabenzimidazoles
发明人：ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARE MARC; R KYEN OMAR; URMANN MATHIAS; HALLAND NIS
权利人:SANOFI SA
摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, wherein R1; R2; R3; R4; J1; J2; J3; J4 and G have the meanings indicated in the claims. The present invention provides a direct metal, e.g. palladium or copper, catalyzed, regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.

专利号:US-6828466-B2
优先权日:2002-07-19
标题:Process for the synthesis of phenols from arenes
发明人：MALECZKA JR ROBERT E; SMITH III MILTON R; HOLMES DANIEL; SHI FENG
权利人:UNIV MICHIGAN STATE
摘要:A process to synthesize substituted phenols such as those of the general formula RR'R''Ar(OH) wherein R, R', and R'' are each independently hydrogen or any group which does not interfere in the process for synthesizing the substituted phenol including, but not limited to, halo, alkyl, alkoxy, carboxylic ester, amine, amide; and Ar is any variety of aryl or hetroaryl by means of oxidation of substituted arylboronic esters is described. In particular, a metal-catalyzed C-H activation/borylation reaction is described, which when followed by direct oxidation in a single or separate reaction vessel affords phenols without the need for any intermediate manipulations. More particularly, a process wherein Ir-catalyzed borylation of arenes using pinacolborane (HBPin) followed by oxidation of the intermediate arylboronic ester by OXONE is described.

专利号:US-RE42890-E
优先权日:2003-05-23
标题 :Furazanobenzimidazoles
发明人：EBERLE MARTIN; BACHMANN FELIX; STREBEL ALESSANDRO; ROY SUBHO; SRIVASTAVA SUDHIR; SAHA GOUTAM
权利人:BASILEA PHARMACEUTICA AG
摘要:The invention relates to compounds of formula (I) wherein R represents aryl or heteroaryl, X is oxygen, a carbonyl group, an oxime derivative of a carbonyl group or an α,β-unsaturated carbonyl group, and the substituents R 1 to R 6 have the meanings given in the specification, for use as medicaments, to novel compounds of formula (I), to methods of synthesis of such compounds, to pharmaceutical compositions containing compounds of formula (I), to the use of a compounds of formula (I) for the preparation of a pharmaceutical composition for the treatment of neoplastic and autoimmune diseases, and to methods of treatment of neoplastic and autoimmune diseases using such compounds of formula (I) or of pharmaceutical compositions containing same

专利号:CA-2693142-A1
优先权日:2007-06-26
标题:A regioselective metal catalyzed synthesis of annelated benzimidazoles and azabenzimidazoles

专利号:CN-105126909-A
优先权日:2015-07-13
标 题 :Application of Immobilized Palladium Catalyst in the Synthesis of Methyl 4-Phenylethynyl-3-nitrobenzoate

专利号:AU-2008267443-A1
优先权日:2007-06-26
标 题 :A regioselective metal catalyzed synthesis of annelated benzimidazoles and azabenzimidazoles