CAS: 103898-11-9; Tert-Butyl Bis(2-Hydroxyethyl)Carbamate

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CAS号24424-99-5 二碳酸二叔丁酯 | CAS号111-42-2 二乙醇胺 | CAS号41840-28-2 S-B°C-2-巯基-4,6-二甲基嘧啶 | CAS号401518-12-5 1-B°C-4-氰基-4-[3... | CAS号401518-11-4 N-B°C-N,N-双{2-[...

二碳酸二叔丁酯,二乙醇胺置于三乙胺体系中,用 二氯甲烷 用作溶剂,化学反应生成N-叔丁氧羰基二乙胺
参考文献:用于dna传递的基于cyclenn的双尾脂质:合成及其连接基团结构的影响
标题:用于dna传递的基于cyclenn的双尾脂质:合成及其连接基团结构的影响
摘要:阳离子脂质的基因转染效率(te)在很大程度上受脂质结构的影响.六种新颖的1,4,7,10-四氮杂十二烷基(环素)基阳离子脂质l1-L6设计并合成了含有双油基作为疏水尾基的化合物.这些脂质之间的区别是它们的不同骨架.由脂质和dope制备的脂质体显示出非常好的dna亲和力,并且可以在n / P为4时实现完全的dna缩合,形成具有适当大小和zeta电位的脂质复合体,用于基因转染.研究了这些脂质作为非病毒基因传递载体的构效关系.研究发现,较小的骨架结构变化(包括连接基团和结构对称性)会影响te.二亚乙基三胺衍生的脂质l4含有酰胺连接键的te效果最好,比市售转染试剂lipofectamine 2000高出几倍.此外,这些脂质显示出低细胞毒性,表明它们具有非常好的生物相容性.结果表明,这种类型的阳离子脂质可能是有前途的非病毒基因载体,也为设计具有更高te和生物相容性的新型载体提供了线索.
Doi:10.1016/j.Bmc.2015.07.005

专利信息

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-2024299311-A1
优先权日:2022-04-05
标题 :Ionizable cationic lipids and lipid nanoparticles
发明人：KARMALI PRIYA PRAKASH; TANIS STEVEN
权利人:KARMALI PRIYA PRAKASH; TANIS STEVEN; CAPSTAN THERAPEUTICS INC
摘要:Ionizable cationic lipids, methods for synthesizing them, as well as intermediates useful in synthesis of these lipids and methods of synthesizing the intermediates are disclosed. The ionizable cationic lipids are useful as a component of lipid nanoparticles (LNP), which in turn can be used for the delivery of nucleic acids into cells in vivo or ex vivo. LNP compositions are also disclosed, including LNP comprising a functionalized lipid to enable conjugation of a binding moiety, and targeted LNP (tLNP), that is a LNP in which a binding moiety has been conjugated to the functionalized lipid and can serve as a targeting moiety to direct the tLNP to a desired tissue or cell type.

专利号:US-2023250056-A1
优先权日:2020-06-24
标 题 :Process for synthesizing lipids
发明人：BEUTNER GREGORY LOUIS; LORA GONZALEZ FEDERICO; CHO PATRICIA Y; SMITH MICHAEL J
权利人:BRISTOL MYERS SQUIBB CO
摘要:The present application provides processes for synthesizing lipids of Formula I useful in the synthesis of fat-soluble compounds for targeting and enhancing activity of therapeutic molecules, including siRNA.

专利号:US-2023265050-A1
优先权日:2020-06-24
标 题 :Process for synthesizing cationic lipids
发明人：BEUTNER GREGORY LOUIS; CARRASQUILLO-FLORES RONALD; LORA GONZALEZ FEDERICO; SMITH MICHAEL J
权利人:BRISTOL MYERS SQUIBB CO
摘要:The present application provides processes for synthesizing cationic lipids of Formula I useful in the synthesis of fat-soluble compositions for targeting and enhancing activity of therapeutic molecules, including siRNA.

专利号:US-8043786-B2
优先权日:2003-03-05
标题 :Acid generators, sulfonic acids, sulfonyl halides, and radiation sensitive resin compositions
发明人：EBATA SATOSHI; WANG YONG; NISHIMURA ISAO
权利人:JSR CORP
摘要:The invention provides novel acid generators which are unproblematic in combustibility and accumulation inside the human body and can generate acids having high acidities and high boiling points and exhibiting properly short diffusion lengths in resist coating films and which permit the formation of resist patterns excellent smoothness with little dependence on the denseness of a mask pattern; sulfonic acids generated from the acid generators; sulfonyl halides useful as raw material in the synthesis of the acid generators; and radiation-sensitive resin compositions containing the acid generators. The acid generators have structures represented by the general formula (I), n nwherein R 1 is a monovalent substituent such as alkoxycarbonyl, alkylsulfonyl, or alkoxysulfonyl; R 2 to R 4 are each hydrogen or alkyl; k is an integer of 0 or above; and n is an integer of 0 to 5. Among the radiation-sensitive resin compositions, a positive one contains a resin having acid-dissociable groups in addition to the above acid generator, while a negative one contains an alkali-soluble resin and a crosslinking agent in addition to the acid generator.

专利号:WO-2025076113-A1
优先权日:2023-10-05
标题:Ionizable cationic lipids with conserved spacing and lipid nanoparticles
发明人：KARMALI PRIYA PRAKASH; TANIS STEVEN; BAO YANJIE
权利人:CAPSTAN THERAPEUTICS INC
摘要:Ionizable cationic lipids, methods for synthesizing the same, intermediates useful in synthesis of the ionizable cationic lipids, and methods of synthesizing the intermediates are disclosed. The ionizable cationic lipids are useful as a component of lipid nanoparticles (LNP), which in turn can be used for delivering nucleic acids into cells in vivo or ex vivo. LNP compositions are also disclosed, including LNP comprising a functionalized lipid to enable conjugation of a binding moiety, and targeted LNP (tLNP), that is a LNP in which a binding moiety has been conjugated to the functionalized lipid and can serve as a targeting moiety to direct the tLNP to a desired tissue or cell type.