CAS: 121-30-2; 4-Amino-6-Chlorobenzene-1,3-Disulfonamide

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CAS号671-89-6 4-氨基-6-氯-1,3-苯二磺酰氯 | CAS号108-42-9 间氯苯胺 | CAS号133-67-5 三氯噻嗪 | CAS号1824-58-4 乙噻嗪 | CAS号58-93-5 氢氯噻嗪 | CAS号1824-52-8 贝美噻嗪 | CAS号2880-40-2 2,5'-dichloro-2... | CAS号2259-96-3 环噻嗪 | CAS号742-20-1 环戊噻嗪 | CAS号58-94-6 氯噻嗪 | CAS号58-93-5 氢氯噻嗪 | CAS号13957-38-5 氢苄噻嗪 | CAS号1580-83-2 氟苄氯噻嗪 | CAS号135-07-9 甲氯噻嗪 | CAS号133-67-5 三氯噻嗪

氢氯噻嗪 以 甲醇 用作溶剂,化学反应 2160.0H,反应生成5-氯-2,4-二磺酰胺基苯胺
参考文献:氢氯噻嗪的稳定性指示试验
标题:氢氯噻嗪的稳定性指示试验
摘要:描述了测定片剂和散装形式中氢氯噻嗪的稳定性指示方法.用甲醇溶解或萃取氢氯噻嗪.将含有磺胺嘧啶作为内标的溶液的等分试样在10微米c18色谱柱上进行色谱分离,用含5%甲醇作为改性剂的水相流动相.用乙酸将ph调节至约4.5.该方法对9个批次(四个不同的供应商)的片剂和两个批次的药品(两个不同的供应商)给出了准确的结果.该测定法的相对标准偏差为约1%.该方法也可以用作氢氯噻嗪中杂质的测试.这项研究中的数据表明,对于杂质在0.1%到5%之间的测试,该测试应给出准确的结果.
Doi:10.1002/jps.2600700225

专利信息

专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:US-2008287407-A1
优先权日:2003-12-10
标题 :Nitric Oxide Releasing Pyruvate Compounds, Compositions and Methods of Use
发明人：GARVEY DAVID S; FANG XINQIN; KHANAPURE SUBHASH P; RANATUNGA RAMANI R; WEY SHIOW-JYI
权利人:NITROMED INC
摘要:The invention describes novel nitrosated and/or nitrosylated pyruvate compounds and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or nitrosylated pyruvate compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one pyruvate compound and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one pyruvate compound, that is optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating diseases resulting from oxidative stress, diabetes, reperfusion injury following ischemia, preservation of tissues, organs, organ parts and/or limbs.

专利号:US-10814013-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

专利号:AU-2007308022-A2
优先权日:2006-10-05
标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

专利号:AU-2007308022-A1
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

专利号:US-2008107598-A1
优先权日:2006-10-05
标 题:Efficient Synthesis of Chelators for Nuclear Imaging and Radiotherapy: Compositions and Applications