CAS: 244105-55-3; 4-Amino-1-((2R,3R,4R,5R)-4-Hydroxy-5-(Hydroxymethyl)-3-(2-Methoxyethoxy)Tetrahydrofuran-2-yl)-5-Methylpyrimidin-2(1H)-One

相似化合物

113886-70-7 223777-16-0 2140-61-6

专利信息

专利号:US-7002006-B2
优先权日:2003-02-12
标 题:Protection of nucleosides
发明人：SONG QUANLAI; ROSS BRUCE S
权利人:ISIS PHARMACEUTICALS INC
摘要:A process of manufacturing protected nucleosides comprises reacting a nucleoside with a protecting reagent in the presence of a regioselective activator to produce a regioselectively protected nucleoside. In some embodiments of the inventive method, an optionally substituted trityl or optionally substituted pixyl group is selectively added to the 5'-O-position of a nucleoside in the presence of lutidine as activator or activator/solvent. The inventive method results in improved selectivity of the 5'-O-position over the 3'-O-position, thereby improving overall product yield and purity, and permitting simplified purification protocols, in some cases obviating the need for chromatography to produce a purified protected nucleoside suitable for automated synthesis of oligonucleotides, such as primers, probes and antisense molecules.

专利号:US-2015139987-A1
优先权日:2013-11-20
标 题 :Treatment of homozygous familial hypercholesterolemia
发明人：MARTIN ROBERT L; MCWHERTER CHARLES A; O'MARA PATRICK J
权利人:CYMABAY THERAPEUTICS INC
摘要:Treatment of homozygous familial hypercholesterolemia by administration of (R)-2-(4-((2-ethoxy-3-(4-(trifluoromethyl)phenoxy)propyl)thio)-2-methylphenoxy)acetic acid or a salt thereof, optionally in combination with an MTP inhibitor, an apoB-100 synthesis inhibitor, or a PCSK9 inhibitor.

专利号:US-12338436-B2
优先权日:2018-06-29
标题 :Synthetic guide molecules, compositions and methods relating thereto
发明人：SACCOMANO SAM; CAPEHART STACY; EATON BRUCE; BERRY KARIN ZEMSKI
权利人:EDITAS MEDICINE INC
摘要:Chemical syntheses of guide molecules are disclosed, along with compositions and methods relating thereto. A cost-effective and straightforward chemical synthesis of high-purity unimolecular guide molecules with minimal n−1 and/or n+1 species, truncation species, and other contaminants by providing, among other things, methods for synthesizing unimolecular guide molecules that involve cross-linking two or more pre-annealed guide fragments.

专利号:CN-118047824-A
优先权日:2024-04-01
标 题:Application of dialkylphosphonic acid in oligonucleotide synthesis

专利号:CN-118047824-B
优先权日:2024-04-01
标题 :Application of dialkylphosphonic acid in oligonucleotide synthesis