CAS: 3430-17-9; 2-Bromo-3-Methylpyridine

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CAS号1603-40-3 2-氨基-3-甲基吡啶 | CAS号1003-56-1 2-羟基-3-甲基吡啶 | CAS号13534-89-9 2,3-二溴吡啶 | CAS号74-88-4 碘甲烷 | CAS号109-04-6 2-溴吡啶 | CAS号626-05-1 2,6-二溴吡啶 | CAS号101419-76-5 2-(4-氟苯基)-3-甲基吡啶 | CAS号109-06-8 2-甲基吡啶 | CAS号4411-80-7 6,6′-二甲基-2,2′-联吡啶 | CAS号108-99-6 3-甲基吡啶 | CAS号1762-32-9 3,3-二甲基-2,2-联吡啶 | CAS号4930-99-8 2-肼基-3-甲基吡啶 | CAS号94446-97-6 2-溴-3-(溴甲基)吡啶 | CAS号18368-66-6 3-甲基-2(1H)-吡啶硫酮 | CAS号19230-57-0 2-溴-3-甲基吡啶1-氧化物

3-甲基-2-吡啶甲酸置于次氯酸叔丁酯,二氯甲烷,氧气,碳酸氢钠体系中,化学反应 20.0H,以70%的收率获得2-溴-3-甲基吡啶
参考文献:在氧条件下用2-卤代甲烷对2-吡啶甲酸进行无过渡金属的脱羧卤化作用†
标题:在氧条件下用2-卤代甲烷对2-吡啶甲酸进行无过渡金属的脱羧卤化作用†
摘要:描述了一种方便有效的合成2-卤素取代的吡啶的方法.经由n-氯卡宾中间体使2-吡啶甲酸与二卤代甲烷的脱羧卤化反应顺利进行,以令人满意的收率在无过渡金属的条件下提供2-卤素取代的吡啶.这种新型的脱羧卤化反应操作简单,并且具有很高的官能团耐受性.
Doi:10.1039/c9Gc02407G

专利信息

专利号:US-6608202-B1
优先权日:2001-08-21
标题:Process of synthesis of a tricyclic ketone intermediate
发明人：DORAN HENRY J; O'NEILL PAT M; WILLIAMS ROBERT P
权利人:SCHERING CORP
摘要:In one embodiment, the present invention describes the synthesis of a compound of Formula III, wherein X is halogen,and intermediates therefor from easily available starting materials by a simple route.

专利号:US-7884125-B2
优先权日:2008-04-30
标 题:Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues
发明人：STEVENS CHRISTIAN; HEUGEBAERT THOMAS
权利人:UNIV GENT
摘要:The present invention relates to a group of substituted-7-azabicyclo-[2.2.1]heptyl derivatives with biological activity. The present invention also relates to synthetic methods for producing said substituted-7-azabicyclo-[2.2.1]heptyl derivatives. The present invention also relates to certain intermediates for producing such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as a synthetic method for producing such intermediates. The present invention also relates to pharmaceutical compositions comprising such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as their use as medicaments for the treatment of diseases mediated by a Nicotinic Acetylcholine Receptor or a receptor being a member of the Neurotransmitter-gated Ion Channel Superfamily, such as pain, Alzheimer's disease, Parkinson's disease, schizophrenia, epilepsy and nicotine addiction.

专利号:US-5998620-A
优先权日:1997-03-25
标 题 :Synthesis of intermediates useful in preparing tricyclic compounds
发明人：CHEN XING; POIRIER MARC; WONG YEE-SHING; WU GUANG-ZHONG
权利人:SCHERING CORP
摘要:The invention relates to a process for preparing a compound of the formula ##STR1## comprising reacting a bromo-substituted pyridine with an amine of the formula NHR 5 R 6 , reacting the resulting amide with an iodo-halomethyl-substituted compound and cyclizing the resultant product, wherein R, R 1 , R 2 , R 3 and R 4 are as defined in the specification; also claimed are a compound of the formula ##STR2## and a process for preparing it from the corresponding halo-substituted benzoic acid.

专利号:US-6495689-B2
优先权日:1998-11-20
标题 :Synthesis of intermediates useful in preparing tricyclic compounds
发明人：BERNARD CHARLES F; CASEY MICHAEL; CHEN FRANK XING; GROGAN DENISE C; POIRIER MARC; WILLIAMS ROBERT P; WONG YEE-SHING; WU GEORGE G
权利人:SCHERING CORP
摘要:Disclosed is a process for preparing a compound having the formula:wherein R, R1, R2, R3, and R4 are independently selected from the group consisting of H, Br, Cl, F, alkyl, or alkoxy.

专利号:EP-0977739-B1
优先权日:1997-03-25
标题 :Synthesis of intermediates useful in preparing tricyclic compounds
发明人：CHEN XING; POIRIER MARC; WONG YEE-SHING; WU GUANG-ZHONG
权利人:SCHERING CORP
摘要:The invention relates to a process for preparing a compound of formula (I), comprising reacting a bromo-substituted pyridine with an amine of the formula NHR5R6, reacting the resulting amide with an iodo-halomethyl-substituted compound and cyclizing the resultant product, wherein R, R?1, R2, R3 and R4¿ are as defined in the specification; also claimed are a compound of formula (a), and a process for preparing it from the corresponding halo-substituted benzoic acid.

专利号:US-2024400552-A1
优先权日:2016-11-11
标题 :Heterocyclic modulators of lipid synthesis
发明人：BUCKLEY DOUGLAS I; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
权利人:SAGIMET BIOSCIENCES INC
摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by dysregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).