CAS: 38521-06-1; 2-Mercaptopyrazine

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80458-31-7 1206524-05-1 1286744-12-4

上下游产品

CAS号14508-49-7 2-氯吡嗪

2-氯吡嗪置于硫化氢,Sodium Methylate体系中,用 甲醇 用作溶剂,化学反应 1.0H,以91%的收率获得2-巯基吡嗪
参考文献:金属化的ť丁基亚砜,砜和哒嗪和吡嗪磺胺类药物.二嗪的金属化.Xx
标题:金属化的ť丁基亚砜,砜和哒嗪和吡嗪磺胺类药物.二嗪的金属化.Xx
摘要:在哒嗪系列中,已经测试了使用叔丁基亚磺酰基和叔丁基磺酰基作为金属的邻位导向基团.以高收率获得了各种功能化产品.在3-的情况下,叔丁基亚-6-Methoxypyridazine,所述金属化中是区域选择性的邻位的亚磺酰基.2-叔丁基亚磺酰基和2-叔丁基磺酰基吡嗪的金属化得到低至中等的收率.改进了二嗪磺酰胺的合成,并实现了n-叔丁基磺酰胺基吡嗪的金属化.
Doi:10.1002/jhet.5570350228

专利信息

专利号:US-7741475-B2
优先权日:2006-02-13
标题:Synthesis of monovalent and polyvalent arabinans and mannose-capped arabinans of the protective cell-wall coat of mycobacterium tuberculosis
发明人：FRASER-REID BERTRAM; LU JUN
权利人:NATURAL PRODUCTS & GLYCOTECHNO
摘要:The present application provides arabinans and mannose-capped arabinan compositions of formulas I-VIII, described herein, and methods of making the compositions.

专利号:US-8673885-B1
优先权日:2010-07-25
标 题 :Compounds for the protection of sulfur containing linkers in nucleic acid synthesis
发明人：DUFF ROBERT
权利人:DUFF ROBERT
摘要:Aromatic and alkyl thiocarbonates with and without a neighboring group that participates in the hydrolysis of a thiocarbonate are described. The aromatic or alkyl thiocarbonates can be used for the protection of sulfur during oligonucleotide synthesis. Their facile processes of manufacture and methods of using the same are provided.

专利号:WO-2011047481-A1
优先权日:2009-10-23
标题 :Novel spiro compounds useful as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：FORTIN REJEAN; LACHANCE NICOLAS; LI CHUN SING; TRANMER GEOFFREY
权利人:MERCK FROSST CANADA LTD; FORTIN REJEAN; LACHANCE NICOLAS; LI CHUN SING; TRANMER GEOFFREY
摘要:Heteroaromatic compounds of structural formula I are selective inhibitors of stearoyl- coenzyme. A delta-9 desaturase (SCDl) relative to other known stearoyl-coenzyme. A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis. Formula (I).

专利号:WO-9505391-A1
优先权日:1993-08-18
标 题 :Applications of fluorescent n-nucleosides and fluorescent structural analogs of n-nucleosides
发明人：CONRAD MICHAEL J
权利人:CHROMAGEN INC
摘要:Structural analogs of the six non-fluorescent N-nucleosides commonly found in RNA and DNA, which are inherently fluorescent under physiological conditions, are identified and methods for their preparation provided. Such analogs may be incorporated into DNA and/or RNA oligonucleotides via either enzymatic or chemical synthesis to produce fluorescent oligonucleotides having prescribed sequences. Such analogous sequences may be identical to, or the analogous complement of, template or target DNA or RNA sequences to which the fluorescent oligonucleotides can be hybridized. Methods of preparing either RNA or DNA oligonucleotide probes of the invention, intermediates used in such methods, and methods of using the probes of the invention in oligonucleotide amplification, detection, identification, and/or hybridization assays are also provided.

专利号:US-2008015344-A1
优先权日:2006-02-13
标 题:Synthesis of monovalent and polyvalent arabinans and mannose-capped arabinans of the protective cell-wall coat of mycobacterium tuberculosis

专利号:US-8076496-B2
优先权日:2000-03-16
标题:Chemoselective ligation
发明人：SAXON ELIANA; BERTOZZI CAROLYN RUTH
权利人:SAXON ELIANA; BERTOZZI CAROLYN RUTH; UNIV CALIFORNIA
摘要:The present invention features a chemoselective ligation reaction that can be carried out under physiological conditions. In general, the invention involves condensation of a specifically engineered phosphine, which can provide for formation of an amide bond between the two reactive partners resulting in a final product comprising a phosphine moiety, or which can be engineered to comprise a cleavable linker so that a substituent of the phosphine is transferred to the azide, releasing an oxidized phosphine byproduct and producing a native amide bond in the final product. The selectivity of the reaction and its compatibility with aqueous environments provides for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).