CAS: 461-18-7; 4,4,4-Trifluorobutan-1-Ol

相似化合物

371-26-6 406-93-9 352-61-4

上下游产品

CAS号677-21-4 3,3,3-三氟丙烯 | CAS号96-48-0 γ-丁内酯 | CAS号461-17-6 1,1,1-三氟-4-碘丁烷 | CAS号371-26-6 4,4,4-三氟丁酸乙酯 | CAS号57769-01-4 potassium salt ... | CAS号406-87-1 4,4,4-三氟丁醛 | CAS号25597-16-4 4,4,4-三氟丁烯酸乙酯 | CAS号406-93-9 4,4,4-三氟丁酸 | CAS号372-30-5 4,4,4-三氟-3-羟基丁酸乙酯 | CAS号84153-82-2 4,4,4-三氟丁-1-胺盐酸盐 | CAS号461-17-6 1,1,1-三氟-4-碘丁烷 | CAS号406-87-1 4,4,4-三氟丁醛 | CAS号406-81-5 1-溴-4,4,4-三氟丁烷 | CAS号84153-82-2 4,4,4-三氟丁-1-胺盐酸盐 | CAS号819-46-5 4,4,4-三氟丁胺 | CAS号164523-19-7 4,4,4,-三氟丁烷-1-醇甲烷硫酸盐 | CAS号212190-13-1 (4,4,4-三氟丁基)硫氰酸酯 | CAS号89866-61-5 5,5,5-三氟戊腈

3,3,3-三氟丙烯置于硼酸三甲酯,二叔丁基过氧化物体系中,化学反应 18.0H,反应生成 4,4,4-三氟丁醇
参考文献:Manufacture Of Fluorinated Alcohols
标题:Manufacture Of Fluorinated Alcohols
摘要:本发明涉及一种用于制造氟化醇和硼酸盐的工艺,该硼酸盐用于制造氟化醇.通过加热公式为hochrcf(Cf3)Chfcf(Cf3)2和hochrcf(Cf(Cf3)2)Chfcf3,Hochrcf(Cf2Cf3)Ch(Cf3)2和hochrc(Cf3)2Chfcf2Cf3的氟化醇的混合物与公式为(Rch2O)3B的硼酸盐(其中r=h或c1至c7烷基)以及全氟-4-甲基-2-戊烯或全氟-2-甲基-2-戊烯和自由基引发剂反应,形成硼酸盐的混合物,可选择地将硼酸盐的混合物与任何反应物,溶剂和副产物分离;水解硼酸盐的混合物以形成水解产物混合物;并从水解产物混合物中分离出醇.

专利信息

专利号:US-5654473-A
优先权日:1995-03-16
标题:Intermediates for the synthesis of trifluoromethylated organic compounds
发明人：VAN DER PUY MICHAEL
权利人:ALLIED SIGNAL INC
摘要:Novel trifluoromethylated intermediates are provided which are useful in synthesizing trifluoromethylated organic compounds. Specifically, compounds of the formula CF 3 CClâ•?CHCH 2 X are provided, which compounds are versatile intermediates for the synthesis of a wide variety of trifluoromethylated organic compounds.

专利号:US-6111130-A
优先权日:1998-05-14
标题:Process for the preparation of trifluoromethyl containing derivatives
发明人：VAN DER PUY MICHAEL
权利人:ALLIED SIGNAL INC
摘要:The present invention relates to a process for the preparation of trifluoromethylated derivatives of the formula CF 3 CClâ•?CHCH 2 OC(â•?O)R, wherein R is unsubstituted or substituted C 1 to C 6 straight chain or branched alkyl, unsubstituted or substituted C 3 to C 7 cycloalkyl, unsubstituted or substituted C 2 to C 12 alkenyl, a benzyl group unsubstituted or substituted with R', a phenyl group unsubstituted or substituted with R'; R' is an unsubstituted or substituted C 1 to C 6 straight chain or branched alkyl; and wherein where R and/or R' are substituted each is substituted with R', by reaction of HCFC-353 with carboxylic acid salts. The trifluoromethylated derivatives, particularly CF 3 CClâ•?CHCH 2 OC(â•?O)CH 3 , are versatile intermediates for the synthesis of a wide variety of trifluoromethylated organic compounds, which find utility as pharmaceuticals, agricultural chemicals, and materials such as liquid crystals.

专利号:US-2008280855-A1
优先权日:2005-06-22
标 题 :Process For the Production of Intermediates For the Preparation of Tricyclic Benzimidazoles
发明人：CHIESA MARIA VITTORIA; PALMER ANDREAS; BUHR WILM; ZIMMERMANN PETER JAN; BREHM CHRISTOF; SIMON WOLFGANG-ALEXANDER; POSTIUS STEFAN; KROMER WOLFGANG; ZANOTTI-GEROSA ANTONIO
权利人:NYCOMED GMBH
摘要:The invention relates to a process for the synthesis of compounds of the formula 1-a and compounds of the formula 1-b. n n n n n n n n n n The compounds of the formula 1-a and the compounds of the formula 1-b, in which the substituents R1, R2, R3, and Ar have the meanings indicated in the description, are valuable intermediates for the preparation of pharmaceutically active compounds.

专利号:WO-2007141253-A1
优先权日:2006-06-07
标 题 :Process for the production of intermediates for the preparation of tricyclic imidazopyridines
发明人：PALMER ANDREAS; BUHR WILM; ZIMMERMANN PETER JAN; BREHM CHRISTOF; CHIESA MARIA VITTORIA; ZANOTTI-GEROSA ANTONIO
权利人:NYCOMED GMBH; PALMER ANDREAS; BUHR WILM; ZIMMERMANN PETER JAN; BREHM CHRISTOF; CHIESA MARIA VITTORIA; ZANOTTI-GEROSA ANTONIO
摘要:The invention relates to a process for the synthesis of compounds of the formula (1-a) and compounds of the formula (1-b). The compounds of the formula 1-a and the compounds of the formula 1-b, in which the substituents R1, R2, R3, and Arom have the meanings indicated in the description, are valuable intermediates for the preparation of pharmaceutically active compounds.

专利号:US-2006167268-A1
优先权日:2002-04-09
标 题:Growth hormone secretagogues
发明人：EVERS BRITTA; GERD RUEHTER; MARTIN DE LA NAVA EVA M; TEBBE MARK J
权利人:ELI LILLY AND COMPANY PATENT D
摘要:This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.

专利号:US-7420070-B2
优先权日:2000-12-28
标 题:Process for preparing optically active 2,3-dihydrobenzofuran compounds
发明人：AOKI ISAO; ADACHI MARI; TAWADA HIROYUKI; YAMASHITA MAKOTO; SERA MISAYO
权利人:TAKODA PHARMACEUTICAL COMPANY
摘要:A process for preparing optically active 2,3-dihydrobenzofuran compounds which comprises subjecting a 2,3-dihydrobenzofuran compound represented by the general formula or a salt thereof to optical resolution with an optically active acid compound: n n[wherein R 1 and R 2 are each hydrogen or an optionally substituted hydrocarbon group; R 3 is an optionally substituted aromatic group; and C is a benzene ring which may further have a substituent in addition to the amino group]. The process enables industrially advantageous production of intermediates for the synthesis of optically active 2,3-dihydrobenzofuran compounds useful as preventive and/or therapeutic drugs for neurodegenerative diseases and so on.