CAS: 86-79-3; 2-Hydroxycarbazole

• 英文名称2-Hydroxycarbazole
• 中文名称2-羟基咔唑
• IUPAC名称9H-carbazol-2-ol
• 其它别名2-羟基咔唑; 2-咔唑醇; 9H-Carbazol-2-Ol
• CAS编号86-79-3
• MFCD编号:MFCD00004962
• EINECS号:201-699-7
• FDA UNII编号:SH4E4EQ2YZ
• 分子式:C12H9NO
• 分子量:183.21
• 产品CID: 1871036
• 产品分类有机原料→分子砌块→芳杂环类化合物→咔唑类化合物

• 相似结构搜索
• InChIKey: GWPGDZPXOZATKL-UHFFFAOYSA-N
• InChI=1S/C12H9NO/c14-8-5-6-10-9-3-1-2-4-11(9)13-12(10)7-8/h1-7,13-14H…
• 计算化学: 氢键受体数1.0氢键供体数2可旋转键数0

相似化合物

物理性质

• 熔点270-273°C
• 沸点316.88 °C at 760 mmHg
• 闪点214.7 °C
• 密度1.362g/cm3
• pKa:10.05±0.30(预测)
• PSA:36.02
• LogP:3.0267
• 折射率1.815
• 蒸汽压4.78E-08 mmHg at 25 °C
• 外观形态灰色固体
• 储存条件2-8°C, 氮气保护
• 产品应用该化合物用于合成异甲酸酯(4AS,13BR)-2,5,5-三甲基-3,4,4A,5,8,13B-HEXA HYDROOSOMENO[3,4(B)CARBAZIOL.

MSDS等安全信息

• GHS象形图
• GHS符号GHS07;
  注释: Exclamation mark
• 危险类别特定目标器官毒性 - 单次接触 类别3
  皮肤腐蚀/刺激 类别2
  严重眼刺激 类别2
  急性毒性 类别4(经口)
  严重眼刺激 类别2A
• 警示词Warning(警告)
• 危险描述H335 |可能引起呼吸道刺激.
  H315 |造成皮肤刺激.
  H319 |造成严重眼刺激.
  H302 |吞咽有害.
• 防范说明P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
• 危险品标志Xi,C,T,F
• 安全声明26-36-37/39-45-36/37/39-27
• 危险类别码36/37/38-34
• WGK Germany2

欧盟法规

上下游产品

合成工艺路线路线简述

• 合成目标产物 2-Hydroxycarbazole 主要起始原料 Cyclohexanone
• 68523-24-0 = 86-79-3
  反应条件:1.1 Catalysts: Tripotassium Phosphate Solvents: Methanol; 10 H,30 °C
  标题:A Photochemical Synthesis Of 2-Hydroxycarbazole
  作者:Liu,Rui; Et Al
  参考文献:Zhejiang Gongye Daxue Xuebao 日期:2012 卷标:40(4) 页码:405-407]
  
  76834-74-7 = 86-79-3 [标题:Reaction Conditions
  标题:Flash-Vacuum Pyrolysis Of 5-(Indol-2- And -3-Ylmethylene)-2,2-Dimethyl-1,3-Dioxane-4,6-Diones
  作者:Banzies,David W. M.; Et Al
  参考文献:Journal Of The Chemical Society 日期:1986 卷标:(9) 页码:1651-4]
  
  16098-16-1 = 86-79-3
  反应条件:1.1 Reagents: Boron Tribromide Solvents: Dichloromethane; 5 H,Rt2.1 Catalysts: 1,10-Phenanthroline,Disodium Tetrachloropalladate Solvents: Dimethylformamide; 10 Min,Rt2.2 Reagents: Phenyl Formate,Trisodium Phosphate; 5 H,170 °C2.3 Reagents: Hydrochloric Acid Solvents: Water; Acidified
  标题:Catalytic Reductive Cyclization Of 2-Nitrobiphenyls Using Phenyl Formate As Co Surrogate: A Robust Synthesis Of 9H-Carbazoles
  作者:Ramadan,Doaa R.; Et Al
  参考文献:Journal Of Catalysis 日期:2022 卷标:409 页码:41-47]
  
  2033-24-1 + 5416-80-8 = 86-79-3
  反应条件:1.1 Reagents: Benzene,Piperidine Solvents: Benzene2.1 -
  标题:Flash-Vacuum Pyrolysis Of 5-(Indol-2- And -3-Ylmethylene)-2,2-Dimethyl-1,3-Dioxane-4,6-Diones
  作者:Banzies,David W. M.; Et Al
  参考文献:Journal Of The Chemical Society 日期:1986 卷标:(9) 页码:1651-4]
  
  99847-12-8 = 86-79-3
  反应条件:1.1 Catalysts: 1,10-Phenanthroline,Disodium Tetrachloropalladate Solvents: Dimethylformamide; 10 Min,Rt1.2 Reagents: Phenyl Formate,Trisodium Phosphate; 5 H,170 °C1.3 Reagents: Hydrochloric Acid Solvents: Water; Acidified,Reflux2.1 Reagents: Sodium Hydroxide Solvents: Ethanol,Water; 16 H,Reflux; Reflux -> Rt2.2 Reagents: Hydrochloric Acid Solvents: Water; Acidified,Rt
  标题:Catalytic Reductive Cyclization Of 2-Nitrobiphenyls Using Phenyl Formate As Co Surrogate: A Robust Synthesis Of 9H-Carbazoles
  作者:Ramadan,Doaa R.; Et Al
  参考文献:Journal Of Catalysis 日期:2022 卷标:409 页码:41-47]
  
  51264-59-6 = 86-79-3 + 65975-66-8
  反应条件:1.1 Reagents: Triphenylphosphine Catalysts: Dichlorobis(N,N-Dimethylformamide-Ko)Dioxomolybdenum Solvents: Toluene; 16 H,Reflux
  标题:Dioxomolybdenum(Vi)-Catalyzed Reductive Cyclization Of Nitroaromatics. Synthesis Of Carbazoles And Indoles
  作者:Sanz,Roberto; Et Al
  参考文献:Advanced Synthesis & Catalysis 日期:2007 卷标:349 页码:713-718]
  
  13314-79-9 = 86-79-3
  反应条件:1.1 Catalysts: Palladium Solvents: 2-Ethylhexanol; 4 H,180 °C; 180 °C -> 50 °C; 50 °C -> Rt1.2 Solvents: Dichloromethane; Rt; 5 H,Rt
  标题:Process For Obtaining High-Purity 2-Hydroxycarbazole By Treating The Impure Compound With Oxygen-Containing Solvents And/or Halogenated Solvents
  参考文献:Poland]
  
  51094-28-1 = 86-79-3
  反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Ethanol,Water; 16 H,Reflux; Reflux -> Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; Acidified,Rt
  标题:Catalytic Reductive Cyclization Of 2-Nitrobiphenyls Using Phenyl Formate As Co Surrogate: A Robust Synthesis Of 9H-Carbazoles
  作者:Ramadan,Doaa R.; Et Al
  参考文献:Journal Of Catalysis 日期:2022 卷标:409 页码:41-47]
  
  51264-59-6 = 86-79-3
  反应条件:1.1 Catalysts: 1,10-Phenanthroline,Disodium Tetrachloropalladate Solvents: Dimethylformamide; 10 Min,Rt1.2 Reagents: Phenyl Formate,Trisodium Phosphate; 5 H,170 °C1.3 Reagents: Hydrochloric Acid Solvents: Water; Acidified
  标题:Catalytic Reductive Cyclization Of 2-Nitrobiphenyls Using Phenyl Formate As Co Surrogate: A Robust Synthesis Of 9H-Carbazoles
  作者:Ramadan,Doaa R.; Et Al
  参考文献:Journal Of Catalysis 日期:2022 卷标:409 页码:41-47]
  
  = 86-79-3
  反应条件:1.1 Reagents: P-Toluenesulfonic Acid Solvents: 1,4-Dioxane; Reflux
  标题:The Pummerer Reaction Of Sulfinyl Compounds
  作者:De Lucchi,Ottorino; Et Al
  参考文献:Organic Reactions (Hoboken 日期:1991 卷标:40]
  
  1429337-46-1 = 86-79-3
  反应条件:1.1 Reagents: Sodium Azide Catalysts: Cuprous Iodide (Amberlyst A21-Supported),Amberlyst A 21 Solvents: Dimethylformamide; 48 H,150 °C
  标题:Recyclable Copper Catalyzed Nitrogenation Of Biphenyl Halides: A Direct Approach To Carbazoles
  作者:Ou,Yang; Et Al
  参考文献:Chemical Communications (Cambridge 日期:2013 卷标:49(33) 页码:3473-3475]
  
  103628-66-6 = 86-79-3 [标题:Reaction Conditions
  标题:Procedure For Preparing 2-Hydroxy-5,6,7,8-Tetrahydrocarbazole And Its Alkali And Alkaline Earth Salts And Their Use
  参考文献:Federal Republic Of Germany]
  
  99970-47-5 = 86-79-3 [标题:Reaction Conditions
  标题:Product Class 15: Carbazoles
  作者:Gallagher,P. T.
  参考文献:Science Of Synthesis 日期:2001 卷标:10 页码:693-744]
  
  39180-36-4 = 86-79-3
  反应条件:1.1 Reagents: Potassium Hydroxide Solvents: Methanol; 16 H,Rt2.1 Catalysts: 1,10-Phenanthroline,Disodium Tetrachloropalladate Solvents: Dimethylformamide; 10 Min,Rt2.2 Reagents: Phenyl Formate,Trisodium Phosphate; 5 H,170 °C2.3 Reagents: Hydrochloric Acid Solvents: Water; Acidified,Reflux3.1 Reagents: Sodium Hydroxide Solvents: Ethanol,Water; 16 H,Reflux; Reflux -> Rt3.2 Reagents: Hydrochloric Acid Solvents: Water; Acidified,Rt
  标题:Catalytic Reductive Cyclization Of 2-Nitrobiphenyls Using Phenyl Formate As Co Surrogate: A Robust Synthesis Of 9H-Carbazoles
  作者:Ramadan,Doaa R.; Et Al
  参考文献:Journal Of Catalysis 日期:2022 卷标:409 页码:41-47]
  
  98-80-6 = 86-79-3
  反应条件:1.1 Reagents: Potassium Carbonate Catalysts: Tetrakis(Triphenylphosphine)Palladium Solvents: Toluene,Water; 18 H,Reflux2.1 Reagents: Boron Tribromide Solvents: Dichloromethane; 5 H,Rt3.1 Catalysts: 1,10-Phenanthroline,Disodium Tetrachloropalladate Solvents: Dimethylformamide; 10 Min,Rt3.2 Reagents: Phenyl Formate,Trisodium Phosphate; 5 H,170 °C3.3 Reagents: Hydrochloric Acid Solvents: Water; Acidified
  标题:Catalytic Reductive Cyclization Of 2-Nitrobiphenyls Using Phenyl Formate As Co Surrogate: A Robust Synthesis Of 9H-Carbazoles
  作者:Ramadan,Doaa R.; Et Al
  参考文献:Journal Of Catalysis 日期:2022 卷标:409 页码:41-47

海关参考信息

• 2908199090-其他酚的卤化衍生物
  2908999090-其他酚的硝化衍生物
  2918290000-其他含酚基羧酸
  2905199090-其他饱和一元醇
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• 详情请参考：📖 海关编码查询和海关进出口税则

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• ➥ 象形图和危险代码
• ➥ 防范代码详解
• ➥ 危险代码说明
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• ➥ REACH监管