CAS: 96829-58-2; (S)-(S)-1-((2S,3S)-3-Hexyl-4-Oxooxetan-2-yl)Tridecan-2-Yl 2-Formamido-4-Methylpentanoate

上下游产品

CAS号130676-63-0 N-甲酰基-L-亮氨酸[S-(... | CAS号130676-64-1 (S)-3-己基-5,6-二氢... | CAS号130676-66-3 奥利司他开环杂质 | CAS号130793-26-9 (3S,4R,6S)-3-He... | CAS号130793-27-0 奥利司他USP RC D | CAS号130676-65-2 N-甲酰基-L-亮氨酸(3S,... | CAS号68711-41-1 [S-；E]-7-烯雌酚-10-醇

(S)-Pentadec-2-Yn-4-Ol置于咪唑,喹啉,叔丁基过氧化氢,六甲基磷酰三胺,4-二甲氨基吡啶,正丁基锂,Bis(Acetylacetonate)Oxovanadium,Palladium 10% On Activated Carbon,5% Pd-Caco3,三氟化硼乙醚,Bis(Tetrahydrofuran)-Meso-Tetra(4-Chlorophenyl)Porphyrinato Aluminum Tetracarbonyl Cobaltate,四丁基氟化铵,氢气,Potassium Hydride,1,2-乙二硫醇,1,3-丙二胺,N,N-二异丙基乙胺,N,N'-二环己基碳二亚胺体系中,用 四氢呋喃,甲醇,癸烷,二氯甲烷,N,N-二甲基甲酰胺 作为反应溶剂,-30.0~50.0 °C,6.21 Mpa 条件下,反应 161.5H,反应生成 奥利司他
参考文献:通过环氧高烯丙醇的高度区域和非对映选择性羰基化全合成四氢利普斯他汀和立体异构体
标题:通过环氧高烯丙醇的高度区域和非对映选择性羰基化全合成四氢利普斯他汀和立体异构体
摘要:已经实现了四氢脂抑素 (Thl) 和七种立体异构体的简明对映选择性合成.thl 的合成分 10 步完成,来自非手性炔酮的总产率为 31%.该方法成功的关键是使用双金属 [路易斯酸]+[co(Co)4]-催化剂将对映体纯顺式环氧化物的后期区域选择性羰基化反应为反式-β-内酯.这条通往 Thl 及其立体异构体的路线的成功也证明了羰基化催化剂在复杂分子合成中的实用性及其官能团兼容性.
DOI:10.1021/ja505639U

专利信息

专利号:US-10005720-B2
优先权日:2013-04-05
标题:Compounds useful for the treatment of metabolic disorders and synthesis of the same
发明人：SEXTON JONATHAN Z; BRENMAN JAY E; MUSSO DAVID L
权利人:NORTH CAROLINA CENTRAL UNIV; UNIV NORTH CAROLINA CHAPEL HILL
摘要:The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.

专利号:US-2017268027-A1
优先权日:2014-12-22
标题:Method for synthesis of fatty acids
发明人：CESCUT JULIEN; URIBELARREA JEAN-LOUIS; GUILLOUET STEPHANE; MOLINA-JOUVE CAROLE; SAGNAK RANA
权利人:INST NAT DES SCIENCES APPLIQUEES DE TOULOUSE; CENTRE NAT RECH SCIENT; AGRONOMIQUE INST NAT RECH; FIDOP (FONDS DE DEV DES FILIERES DES OLEAGINEUX ET DES PROTEAGINEUX)
摘要:Disclosed is a method for synthesis of fatty acids by culturing a eukaryotic microorganism from the fungi kingdom, that is naturally oleaginous or rendered oleaginous. The culture is performed in the presence a fatty acid synthase inhibitor in the culture medium.

专利号:US-8729310-B2
优先权日:2009-09-22
标题:Halogenated diarylamine compound and synthesis method thereof
发明人：OSAKA HARUE; INOUE HIROTO
权利人:OSAKA HARUE; INOUE HIROTO; SEMICONDUCTOR ENERGY LAB
摘要:An object is to provide a new halogenated diarylamine compound serving as a source material for synthesis of a variety of diarylamine compounds and triarylamine compounds and a synthesis method of the new halogenated diarylamine compound. A halogenated diarylamine compound represented by the following general formula (G1) and a synthesis method thereof are provided. Note that a variety of diarylamine compounds and triarylamine compounds can be synthesized using the halogenated diarylamine compound represented by the following general formula (G1).

专利号:US-2025235415-A1
优先权日:2022-02-23
标 题:Modulation of human breast milk composition
发明人：ROSS MICHAEL G; DESAI MINA
权利人:LUNDQUIST INST FOR BIOMEDICAL INNOVATION AT HARBOR UCLA MEDICAL CENTER
摘要:Compositions and methods for improving a child, such as an infant's health, are provided. The methods entail improving the quality of breast milk in a female human individual that provides breast milk, or expects to provide breast milk, to the child, by administering to the individual an agent that increases the individual's sensitivity to insulin, and/or an agent that reduces the substrate uptake, synthesis or secretion of long chain fatty acids, reduces the substrate uptake, synthesis or secretion of short chain fatty acids, increases the amino acid uptake, protein synthesis or protein secretion of proteins, or reduces the uptake or synthesis of lactose.

专利号:WO-2025045059-A1
优先权日:2023-09-01
标题 :Use of anti-igf-1r antibody or antigen binding portion thereof in weight loss
发明人：LIANG XIAO; GUO SHUHUA; MA LIN; PANG LIANG
权利人:SUZHOU PRO HEAL PHARMACEUTICALS TECH CO LTD
摘要:Provided is a use of an anti-IGF-1R antibody or an antigen binding portion thereof in weight loss. The anti-IGF-1R antibody or the antigen binding portion thereof carries out weight loss by means of at least one of the following mechanisms: (1) inhibiting or blocking the binding between IGF-1R and IGF-1; (2) reducing, weakening or neutralizing the activity of IGF-1R; (3) inhibiting cell proliferation; (4) inhibiting fat synthesis and/or accumulation of cells; and (5) inhibiting collagen synthesis of cells. The anti-IGF-1R antibody or the antigen binding portion thereof can significantly inhibit the generation and accumulation of fat, effectively inhibit the formation of collagen, and has a significant effect in treatment of obesity and weight loss.

专利号:US-2009156465-A1
优先权日:2005-12-30
标题:Derivatives of beta-amino acid as dipeptidyl peptidase-iv inhibitors
发明人：SATTIGERI JITENDRA A; AHMED SHAHADAT; ANDAPPAN MURUGAIAH M S; SETHI SACHIN; SHARMA LALIMA; PAL CHANCHAL KUMAR; KANDALKAR SACHIN RAMESH; MAHAJAN DIPAK C; KISHORE KAUSHAL; BHATIA SUMATI; GADHAVE ANIL G; BANSAL VINAY S; DAVIS JOSEPH ALEXANAND
权利人:SATTIGERI JITENDRA A; AHMED SHAHADAT; ANDAPPAN MURUGAIAH M S; SETHI SACHIN; SHARMA LALIMA; PAL CHANCHAL KUMAR; KANDALKAR SACHIN RAMESH; MAHAJAN DIPAK C; KISHORE KAUSHAL; BHATIA SUMATI; GADHAVE ANIL G; BANSAL VINAY S; DAVIS JOSEPH ALEXANAND
摘要:The present invention relates to β-amino acid derivatives as dipeptidyl peptidase-IV inhibitors and the processes for the synthesis of the same. This invention also relates to pharmacological compositions containing the compounds of the present invention, and methods of treating diabetes, especially type 2 diabetes, as well as prediabetes, diabetic dyslipidemia, metabolic acidosis, ketosis, satiety disorders, and obesity. These inhibitors can also be used to treat conditions manifested by a variety of metabolic, neurological, anti-inflammatory, and autoimmune disorders like inflammatory disease, multiple sclerosis, rheumatoid arthritis; viral, cancer and gastrointestinal disorders. The compounds of this invention can also be used for treatment of infertility arising due to polycystic ovary syndrome.