CAS: 1070-34-4; 4-Ethoxy-4-Oxobutanoic Acid

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CAS号123-25-1 丁二酸二乙酯 | CAS号108-30-5 丁二酸酐 | CAS号64-17-5 乙醇 | CAS号110-15-6 琥珀酸； 丁二酸 | CAS号3859-41-4 1,3-环戊二酮 | CAS号765-69-5 2-甲基-1,3-环戊二酮 | CAS号150-90-3 丁二酸钠 | CAS号556-32-1 丁二酸镁 | CAS号14794-31-1 丁二酸单乙酯酰氯 | CAS号36092-42-9 2-苄基琥珀酸 | CAS号7149-59-9 3-氧代己二酸二乙酯 | CAS号123-25-1 丁二酸二乙酯 | CAS号110-15-6 琥珀酸； 丁二酸 | CAS号10138-10-0 4-氧代丁酸乙基酯 | CAS号14794-31-1 丁二酸单乙酯酰氯 | CAS号917955-69-2 3-ethoxycarbony... | CAS号93006-72-5 3-(3,4-dihydron... | CAS号946-08-7 ethyl 4-oxo-4-(... | CAS号59086-25-8 4-氧代-4-噻吩-2-基-丁酸乙酯

丁二酸二乙酯置于potassium Hydroxide体系中,用 乙醇 用作溶剂,化学反应生成丁二酸单乙酯
参考文献:通过丙二酸酯衍生物的脱羧胺化反应合成受保护的α-氨基酸.
标题:通过丙二酸酯衍生物的脱羧胺化反应合成受保护的α-氨基酸.
摘要:报道了一种合成保护的α-氨基酸的通用有效策略.该方法以丙二酸酯衍生物为起始原料,以cs 2 Co 3为碱在60度下,通过释放co 2,以中等收率得到α-氨基酸衍生物.该方法学显示了广泛的底物范围(伯酸和仲酸),出色的官能团耐受性和高效率,可在温和的反应条件下提供所需的产物.它还允许构建β和γ-氨基酸以及其他非天然产物.
Doi:10.1039/d0Ob00677G

专利信息

专利号:EP-1721894-A1
优先权日:2005-05-13
标题 :Process for the synthesis of prostaglandin derivatives
发明人：LISI GIUSEPPE
权利人:TECHNOPHARMA SA
摘要:An alternative method for the synthesis of prostaglandin F analogues, in particular, analogues of PGF 2α and specifically for the synthesis of latano-prost, wherein the transformation of the lactone intermediate (5)n ninto the corresponding lactol (7)n nis carried out by treating the lactone intermediate (5) with a silane, preferably polymethylhydrosiloxane (PMHS), in the presence of a titanocene - and preferably titanocene fluoride. n The method enables considerable production economies with respect to the conventional reduction of lactone with diisobutylaluminum hydride (DIBAL-H).

专利号:US-5788950-A
优先权日:1994-08-03
标 题 :Method for the synthesis of mixed metal oxide powders
发明人：IMAMURA KUNIO; DIGREGORIO JOHN F; SMITH DOUGLAS M; IZAWA HIROZUMI; YAMAGUCHI TETSUHIKO
权利人:SHOWA DENKO KK
摘要:A technique to synthesize complex oxide ceramic powders which offers advantages of both the coprecipitation and sol-gel routes while doing away with the disadvantages is disclosed. Namely, the ability to achieve chemical homogeneity and crystallite size on the namometer length scale at a nonprohibitive cost is provided by the disclosed method. In one embodiment of the invention, a method for the synthesis of a mixed metal oxide powder is provided including (a) combining a liquid absorbent resin with at least one solution selected from the group consisting of solutions containing at least one organo-metallic compound and solutions containing at least one metallic salt compound, such that at least two metals are present in the liquid absorbent resin after the combining is completed; (b) after the combining, allowing the liquid absorbent resin to swell and gel and thereby form a swollen gel; (c) preparing a precursor material by changing at least one of the pH and temperature of the swollen gel; (d) pyrolyzing the precursor material to form a pyrolyzed precursor material; and (e) calcining the pyrolyzed precursor material to form a mixed metal oxide powder.

专利号:US-11766432-B2
优先权日:2018-07-27
标题 :Cleavable conjugates of catechol compounds and water-soluble polymers and methods of treatment using the same
发明人：BENTLEY MICHAEL; FANG ZHIHAO; WEIMER REBECCA; VIEGAS TACEY; MOREADITH RANDALL
权利人:SERINA THERAPEUTICS INC
摘要:Described are conjugates comprising a water-soluble polymer linked to a compound comprising a catechol moiety via a cleavable linkage, wherein the cleavable linkage is formed between the water-soluble polymer and a first phenolic hydroxyl group of the catechol moiety and a second phenolic hydroxyl group of the catechol moiety is linked to a blocking group wherein the rate of hydrolytic release of the compound comprising the catechol moiety is controlled, at least in part, through structure or design of the blocking group on the second phenolic hydroxyl group of the catechol moiety. Therefore, the rate of hydrolytic release of the compound comprising the catechol moiety can be tuned through structural design of the group on the second phenolic hydroxyl group of the catechol moiety. Compounds used in the synthesis of the described conjugates and methods of using the described conjugate and other compounds in the treatment of dopamine-responsive disorders are also described.

专利号:US-2024208900-A1
优先权日:2021-04-16
标题 :Synthesis of dimethyl-c17-32-alkyl sulfonium salts
发明人：STROOT JOERG; ZHERSH SERHII; RIPENKO VASYL
权利人:HELM AG
摘要:The invention relates to a process for the preparation of a dimethyl-C 17-32 -alkyl sulfonium salt, preferably a dimethyl-C 17-32 -alkyl sulfonium halide, more preferably a dimethyl-C 17-32 -alkyl sulfonium chloride, still more preferably dimethyl octadecyl sulfonium chloride, the process comprising the steps of: providing a mixture of a C 17-32 -alkyl halide and dimethyl sulfide; and reacting the C 17-32 -alkyl halide with the dimethyl sulfide.

专利号:US-10906895-B2
优先权日:2017-02-16
标 题:Processes for the preparation of benzodiazepine derivatives
发明人：KIM IN JONG; YU JIANMING; BLAISDELL THOMAS P; Panarese Joseph; SHOOK BRIAN C; OR YAT SUN
权利人:ENANTA PHARM INC
摘要:The present invention relates to processes and intermediates useful in the preparation of biologically active molecules, especially in the synthesis of Respiratory Syncytial Virus (RSV) inhibitors. The present invention also relates to processes and intermediates for the preparation of compounds of formula (I): n n n n n n n n n n In particular, the present invention also relates to processes and intermediates for the preparation of compound I-a:

专利号:US-2023212107-A1
优先权日:2021-12-30
标 题:Synthesis of para-alkylated syringyl (meth)acrylate derivatives and photopolymerizable compositions for additive manufacturing in dental applications
发明人：CHOUDHARY UMESH UPENDRA; SU JESSICA KALAY
权利人:ALIGN TECHNOLOGY INC
摘要:The present disclosure provides polymerizable monomers which may be used as reactive diluents in additive manufacturing. The polymerizable monomers may have low vapor pressures and may be compatible with a range of low glass transition temperature oligomers.