CAS: 1150560-54-5; 1-(2-Fluoro-6-(Trifluoromethyl)Benzyl)-5-Iodo-6-Methylpyrimidine-2,4(1H,3H)-Dione

相似化合物

830346-47-9 830346-48-0 2995282-43-2

上下游产品

CAS号830346-47-9 噁拉戈利中间体4

Tert-Butyl (2-Fluoro-6-(Trifluoromethyl)Benzyl)Carbamate置于盐酸,N-碘代丁二酰亚胺,溶剂黄146,Sodium Hydroxide体系中,用 乙醇,水,N,N-二甲基甲酰胺,异丙醇 用作溶剂,化学反应 14.0H,反应生成1-[2-氟-6-(三氟甲基)苄基]-5-碘-6-甲基嘧啶-2,4(1H,3H)-二酮
参考文献: Processes To Produce Elagolix[fr] Processus De Production D'élagolix
标题: Processes To Produce Elagolix[fr] Processus De Production D'élagolix
摘要:本发明涉及一种用于制备依诺司特及其盐和中间化合物的可扩展工艺.

专利信息

专利号:US-11858901-B2
优先权日:2019-10-30
标 题:3-((R)-2-(amino-2-phenylethyl)-1-(2-fluoro-6 trifluoromethyl benzyl)-5-iodo-6-methyl-1H-pyrimidine-2,4-dione or a salt thereof, process for its preparation, and its use in the synthesis of elagolix
发明人：BALLETTE ROBERTO; JIMÉNEZ ALONSO OSCAR; GARCÃ?A GARCÃ?A ELENA; DOBARRO RODRÃ?GUEZ ALICIA
权利人:MOEHS IBERICA SL
摘要:A new intermediate is useful in the synthesis of elagolix. A process for obtaining the intermediate includes reacting a precursor with iodine monochloride in the presence of an organic solvent. A process for preparing elagolix makes use of the intermediate. The intermediate can be 3-((R)-2-(amino-2-phenylethyl)-1-(2-fluoro-6-trifluoromethylbenzyl)-5-iodo-6-methyl-1H-pyrimidine-2,4-dione or a salt thereof, such as a hydrochloride.

专利号:US-2022411382-A1
优先权日:2019-10-30
标 题 :3-((r)-2-(amino-2-phenylethyl)-1-(2-fluoro-6 trifluoromethyl benzyl)-5-iodo-6-methyl-1h-pyrimidine-2,4-dione or a salt thereof, process for its preparation, and its use in the synthesis of elagolix