CAS: 1218-69-5; 2-(2-Hydroxyphenyl)-4H-Benzo[e][1,3]Oxazin-4-One

水杨酰胺置于吡啶,Oxone,四磷十氧化物,Palladium Diacetate,Tert-Butylammonium Hexafluorophosphate(V)体系中,用 5,5-Dimethyl-1,3-Cyclohexadiene,丙酮,乙腈 用作溶剂,化学反应生成2-(2-羟基苯基)-4H-苯并[e][1,3]恶嗪-4-酮
参考文献:钯催化c(sp2)-H的电化学氧化羟化反应合成2-(2-羟基芳基)-4H-苯并[e] [1,3]恶嗪-4-酮
标题:钯催化c(sp2)-H的电化学氧化羟化反应合成2-(2-羟基芳基)-4H-苯并[e] [1,3]恶嗪-4-酮
摘要:以pd(oac)2为催化剂,恶嗪环为导向基团和oxone为羟基化作用开发了2-芳基-4 H-苯并[ E ] [1,3]恶嗪-4-酮的电化学直接邻羟基化反应试剂.在温和条件下获得了一系列羟基化产物,收率从中等到非常好.该方法的特征在于非常好的官能团耐受性和广泛的底物.更重要的是,使用阳极氧化以避免使用潜在的有毒和污染性氧化剂.的2-苯基-4-甲克级直接电化学羟化ħ苯并[ ë进行] [1,3]恶嗪-4-酮的合成,并应用羟基化产物合成地拉罗司.另外,获得了2-(2-羟基苯基)-4-H-苯并[ E ] [1,3]恶嗪-4-酮的单晶并通过x射线衍射测定.最后,提出了反应机理并通过循环伏安法(cv)进行了验证.该协议还提供了分子功能化的另一种电化学羟基化方法.
Doi:10.1002/adsc.202000173

专利信息

专利号:US-8907083-B2
优先权日:2010-08-25
标题 :Process for the preparation, of 2-(2-hydroxyphenyl)-benz [1, 3] oxazin-4-one and its use for preparation of 4-[3, 5-bis (2-hydroxyphenyl)-IH-I, 2, 4-triazolTI-yl] benzoic acid
发明人：DAVULURI RAMAMOHAN RAO; PONNAIAH RAVI; BATTHNI GURUSWAMY; MEDIDA CHANDRA MURTHY V R; DUMMU SANTHOSH
权利人:DAVULURI RAMAMOHAN RAO; PONNAIAH RAVI; BATTHNI GURUSWAMY; MEDIDA CHANDRA MURTHY V R; DUMMU SANTHOSH; RAMAMOHAN RAO DAVULURI
摘要:The invention provides a novel process for the synthesis of 2-(2-hydroxyphenyl)-benz[1,3]oxazin-4-one, the process comprising of reacting the salicylic acid with salicylamide in the presence of p-toluenesulfonyl chloride, base and solvent. The use of 2-(2-hydroxyphenyl)-benz[1,3]oxazin-4-one in the preparation of Deferasirox is also disclosed in the invention.

专利号:WO-2016203488-A1
优先权日:2015-06-16
标 题:Preparation of novel deferasirox analogues for antimalarial activity
发明人：HAVALDAR FREDDY H; DABHOLKAR BHUSHAN VASANT; MULE GANESH BABAN
权利人:HAVALDAR FREDDY H
摘要:The present invention relates to processes for the preparation of novel deferasirox analogues for antimalarial activity. The present invention further provides process for synthesis of novel deferasirox analogues.

专利号:CN-115057827-A
优先权日:2022-07-20
标 题:Deferasirox derivative, synthesis method thereof and application thereof in preparation of medicines for diagnosing and treating iron-overload hepatocellular carcinoma

专利号:CN-115057827-B
优先权日:2022-07-20
标题 :Derasirox derivatives and their synthesis methods and their application in the preparation of drugs for the diagnosis and treatment of iron-overloaded hepatocellular carcinoma