CAS: 1678-49-5; 3-Bromo-4-Nitropyridine 1-Oxide

该化合物是一种七环化合物,其核心为有溴和硝基替代物功能的丙烯核心,以及N-氧化物.这种结构具有独特的反应性,使它在有机合成中成为有价值的中间体,特别是用于制备药品,农用化学品和特殊材料.溴和硝基组通过核循环替代或金属催化交叉相交反应为进一步功能化提供了多功能性场地.N-氧化组增强了电极性,促进了再生选择性修改.在标准处理条件下,其定义明确的再活动特征和稳定性使它成为复杂的分子结构的可靠建筑块.在受控制的环境下,训练有素的专业人员是合适的.

结构式图片

相似化合物

62516-08-9 769-54-0 14432-16-7

上下游产品

CAS号2402-97-3 3-溴吡啶-N-氧化物 | CAS号63785-86-4 3-Bromopyridine... | CAS号626-55-1 3-溴吡啶 | CAS号462-08-8 3-氨基吡啶 | CAS号36953-42-1 3-溴-4-氯吡啶 | CAS号180194-80-3 N-[3-(4-chlorop... | CAS号1796-73-2 N3-甲基吡啶-3,4-二胺 | CAS号82257-09-8 3-溴-4-甲氧基吡啶 | CAS号89364-04-5 3-溴-4-硝基吡啶 | CAS号75115-28-5 3-(苄氨基)-4-氨基吡啶 | CAS号133881-87-5 2-(4-nitro-1-ox... | CAS号13534-98-0 3-溴-4-胺吡啶 | CAS号13959-52-9 4-nitro-1-oxido... | CAS号13535-03-0 4-(Acetylamino)...

合成工艺路线路线简述

    3-Bromo-Pyridine-1-Oxide ; Hydrogenphthalate置于硫酸体系中,化学反应生成3-溴-4-硝基吡啶-N-氧化物
    参考文献:Den Hertog; Overhoff,Recueil Des Travaux Chimiques Des Pays-Bas,1950,Vol. 69,P. 468,472
    标题:Den Hertog; Overhoff,Recueil Des Travaux Chimiques Des Pays-Bas,1950,Vol. 69,P. 468,472

    海关参考信息

    专利信息


    专利号:US-2017355648-A1
    优先权日:2016-04-26
    标题 :Synthesis of meta-substituted [18f]-3-fluoro-4-aminopyridines by direct radiofluorination of pyridine n-oxides

    专利号:US-10160695-B2
    优先权日:2016-04-26
    标 题 :Synthesis of meta-substituted [18F]-3-fluoro-4-aminopyridines by direct radiofluorination of pyridine N-oxides
    发明人:BRUGAROLAS PEDRO
    权利人:UNIV CHICAGO
    摘要:Disclosed herein are methods for the fluorination aromatic N-heterocyclic N-oxides that comprise at least one leaving group. The N-oxides may be reduced to the fluorinated aromatic N-heterocyclic amine analogs. This novel fluorination approach may be successfully applied for synthesizing aromatic N-heterocyclic compounds labeled with 18 F.

    专利号:US-8524905-B2
    优先权日:2007-05-22
    标 题:Processes for preparing 6-(difluoromethoxy)[1]benzofuro[3,2-c]pyridine-9-carbaldehyde, a novel intermediate for the synthesis of PDE IV inhibitors
    发明人:GHARAT LAXMIKANT ATMARAM; GAJERA JITENDRA MAGANBHAI; PATIL SANDIP DAMODAR; KADAM SURESH M
    权利人:GHARAT LAXMIKANT ATMARAM; GAJERA JITENDRA MAGANBHAI; PATIL SANDIP DAMODAR; KADAM SURESH M; GLENMARK PHARMACEUTICALS SA
    摘要:The present invention relates to novel processes for preparing 6-(difluoromethoxy)[1]benzofuro[3,2-c]pyridine-9-carbaldehyde, which is a novel and useful intermediate for preparing compounds with PDE4 inhibitory activity, such as 3,5-dichloro-4-(6-difluoromethoxybenzo[4,5]furo[3,2-c]pyridin-9-ylcarboxamido)-1-pyridiniumolate.

    专利号:WO-2008142542-A2
    优先权日:2007-05-22
    标 题:Processes for preparing benzofuro [3, 2-c] pyridine- 9-carbaldehyde derivatives as novel intermediates for the synthesis of pde iv inhibitors

    专利号:US-2010168151-A1
    优先权日:2007-05-22
    标 题 :Novel processes for preparing 6-(difluoromethoxy)[1]benzofuro[3,2-c]pyridine-9-carbaldehyde, a novel intermediate for the synthesis of pde iv inhibitors

    专利号:US-2008312271-A1
    优先权日:2006-07-25
    标 题 :Azabenzimidazolyl compounds
    发明人:EFREMOV IVAN; ROGERS BRUCE N; DUPLANTIER ALLEN J; ZHANG LEI; ZHANG QIAN; MAKLAD NOHA S
    权利人:PFIZER
    摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I n n n n n n n n n n as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
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    合成参考文献


    摘要:Spitzner, D., Science of Synthesis, (2005) 15, 215.
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