CAS: 26260-02-6; 2-Iodobenzaldehyde

上下游产品

CAS号5159-41-1 2-碘苄醇 | CAS号7022-46-0 2-iodo-N-methyl... | CAS号380151-85-9 2-甲酰基苯硼酸频哪醇酯 | CAS号35822-58-3 2-溴苯甲醛二乙缩醛 | CAS号610-97-9 邻碘苯甲酸甲酯 | CAS号76464-87-4 N-(2-iodobenzyl... | CAS号88-67-5 邻碘苯甲酸 | CAS号152302-84-6 2-iodobenzaldeh... | CAS号609-67-6 2-碘苯甲酰氯 | CAS号38846-64-9 2-乙炔苯甲醛 | CAS号5159-41-1 2-碘苄醇 | CAS号88-67-5 邻碘苯甲酸 | CAS号3770-50-1 吲哚-2-羧酸乙酯 | CAS号52839-45-9 3,4-二苯基异喹啉 | CAS号1801-42-9 2.3-二苯基-1-二氢茚酮 | CAS号53347-50-5 2,3-diphenyl-1H... | CAS号220649-65-0 2-(3-甲氧基-1-丙炔)苯甲醛 | CAS号90-02-8 水杨醛 | CAS号26059-40-5 2-(2-碘苯基)-1-乙醇

2-甲酰基苯硼酸置于七氟-2-碘代丙烷,铜,对苯二酚体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应 24.0H,以83%的收率获得2-碘苯甲醛
参考文献:在室温下用(cf 3)2 Cfi进行铜介导的硼酸好氧碘化和硼酸的全氟烷基化
标题:在室温下用(cf 3)2 Cfi进行铜介导的硼酸好氧碘化和硼酸的全氟烷基化
摘要:描述了支链(cf 3)2 Cfi和硼酸(rb(oh)2)之间的铜介导的好氧反应.不同于线性全氟烷基类似物cf 3(cf 2)n I(n = 2,3,5,7 ),(cf 3)2 Cfi在室温,空气中,催化性cu存在下与rb(oh)2反应粉末仅提供相应的碘化物(ri),而芳基硼酸与(cf 3)2 Cfi在室温下在cu(oac)2存在下的需氧反应产生了全氟烷基化产物(r-Cf(cf 3)2)可接受到中等产量.氢醌可进一步促进碘化反应,对苯二酚的添加提高了(cf 3)2 Cfi的氧化能力,并以高收率提供了碘代碘化产物.羧酸铜促进了全氟烷基化,因为将这些盐添加到反应混合物中可以成功地生成ar-Cf(cf 3)2.
Doi:10.1016/j.Jfluchem.2016.07.021

专利信息

专利号:US-5861532-A
优先权日:1997-03-04
标 题:Solid-phase synthesis of N-alkyl amides
发明人：BROWN EDWARD G; NUSS JOHN M
权利人:CHIRON CORP
摘要:Methods for solid phase synthesis of N-alkyl amides comprise reductive amination of carbonyl compounds using a reducing agent and an amine-containing linker bound to a solid support. The methods afford high yields of linker-bound, monoalkylated amines, and subsequent coupling with acid derivatives provide derivatized N-substituted amides in excellent yields after cleavage from the solid-phase. Compositions useful in solid phase synthesis are also described.

专利号:WO-2021038581-A1
优先权日:2019-08-30
标题 :A one step synthesis of 2-substituted benzo[b]thiophenes
发明人：SEKAR GOVINDASAMY; POONGUZHALI ELAMVAZHUTHI
权利人:INDIAN INST TECH MADRAS
摘要:The invention pertains to a one step synthesis of 2-substituted benzo[ b ]thiophene of general formula wherein the synthesis of 2-substituted benzo[ b ]thiophenes is by reacting the starting materials substituted or unsubstituted 2-halogenobenzaldehyde and substituted or unsubstituted acetyl/phenacyl bromide with a catalyst, a sulphur source and phase transfer catalyst in an aqueous medium with atmospheric air and at temperature in the range of 25°C-30°C.

专利号:US-9597327-B2
优先权日:2005-05-25
标 题:Synthesis of (R)-N-methylnaltrexone
发明人：DOSHAN HAROLD D; PEREZ JULIO
权利人:PROGENICS PHARM INC
摘要:This invention relates to stereoselective synthesis of R-MNTX and intermediates thereof, pharmaceutical preparations comprising R-MNTX or intermediates thereof and methods for their use.

专利号:US-2005014954-A1
优先权日:2001-11-22
标 题:Pyrrole synthesis
发明人：OHRLEIN REINHOLD; BAISCH GABRIELE
摘要:The invention relates to a novel process for the preparation of N-substituted pyrroles, especially of formula (V), wherein the radicals are as defined in the description, by intermolecular aza-Wittig reaction starting from organic azides and 1,4-dioxo compounds. The invention relates also to novel iminophosphorane intermediates for this synthesis. The resulting pyrroles are useful, for example, in the organic synthesis of pharmaceuticals or other active substances and chemicals.

专利号:US-7109377-B2
优先权日:1996-10-16
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
发明人：SCHREIBER STUART L; SHAIR MATTHEW D; TAN DEREK S; FOLEY MICHAEL A; STOCKWELL BRENT R
权利人:HARVARD COLLEGE
摘要:The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.

专利号:US-8026383-B2
优先权日:2001-07-06
标题:Process for the preparation of intermediates useful in the synthesis of statin derivatives
发明人：OEHRLEIN REINHOLD; BAISCH GABRIELE; END NICOLE; BURKHARDT STEPHAN; STUDER MARTIN
权利人:BASF SE
摘要:The invention relates to novel synthesis methods for the preparation of statin derivatives, which methods proceed by way of a key intermediate of formula I n nwherein X is halogen, acyloxy, activated hydrocarbyloxy, activated hydrocarbylthio or —N(CH 3 )OCH 3 , R a is a hydroxy-protecting group and R b is a carboxy-protecting group, and, as well as to the compound of formula I, to further new intermediates and methods for their preparation by Friedel-Crafts acylation.