专利号:US-6835849-B2 优先权日:2002-07-15 标题:Synthesis of alkenoate esters from lactones and alcohols 发明人:MANZER LEO ERNEST 权利人:DU PONT 摘要:The invention relates to the synthesis of alkenoate esters from a corresponding lactone and an alcohol in the presence of a basic catalyst. More specifically, this invention relates to the synthesis of methyl-4-pentenoate ester from 5-methyl butyrolactone and methanol.
专利号:WO-2012059797-A1 优先权日:2010-11-04 标题 :Process for synthesis of (s) - pregabalin 发明人:ROY BHAIRAB NATH; SINGH GIRIJ PAL; LATHI PIYUSH SURESH; AGRAWAL MANOJ KUNJABIHARI; MITRA RANGAN; RUPNAWAR MANOJ DATTATRAYA 权利人:LUPIN LTD; ROY BHAIRAB NATH; SINGH GIRIJ PAL; LATHI PIYUSH SURESH; AGRAWAL MANOJ KUNJABIHARI; MITRA RANGAN; RUPNAWAR MANOJ DATTATRAYA 摘要:Improved process for the synthesis of (S)-pregabalin having more than 99% ee through (S) 3-cyano-5-methyl-hexanoic acid has been developed. In addition to above, a novel process for resolution of ( RS ) - 3-cyano-5-methyl-hexanoic acid through diastereomeric salt formation with cinchonidine to obtain ( S ) - 3-cyano-5-methyl-hexanoic acid in high yield and high optical purity has been developed and furthermore process for recovery/ reuse of cinchonidine is also developed to improve the overall process efficiency.
专利号:WO-03018540-A1 优先权日:2001-08-22 标 题:Synthesis of unsaturated nitriles from lactones 发明人:MANZER LEO E 权利人:DU PONT; MANZER LEO E 摘要:The synthesis of unsaturated nitriles from lactones and ammonia is described using a heterogeneous base catalyst.
专利号:US-9328109-B2 优先权日:2013-01-14 标 题:Process for the preparation of benzohetero [1, 3] diazole compounds disubstituted with heteroaryl groups 发明人:BIANCHI GABRIELE; PO' RICCARDO 权利人:ENI SPA 摘要:Process for the preparation of a benzohetero-[1,3]diazole compound disubstituted with brominated heteroaryl groups which comprises reacting at least one dihalogenated benzohetero[1,3]diazole compound with at least one brominated heteroaryl compound. Said benzohetero[1,3]diazole compound disubstituted with brominated heteroaryl groups can be advantageously used in the synthesis of compounds useful in the construction of solar concentrators (LSCs—“Luminescent Solar Concentratorsâ€?). Furthermore, said benzohetero[1,3]diazole compound disubstituted with brominated heteroaryl groups can be advantageously used in the synthesis of photoactive polymers useful in the construction of photovoltaic devices (or solar devices) such as, for example, photovoltaic cells (or solar cells), photovoltaic modules (or solar modules), on both rigid or flexible supports. Furthermore, said benzohetero[1,3]diazole compound disubstituted with brominated heteroaryl groups can be advantageously used as precursor of monomeric units in the synthesis of semiconductr polymers.
专利号:US-2010102700-A1 优先权日:2008-10-24 标题:Flame spray pyrolysis with versatile precursors for metal oxide nanoparticle synthesis and applications of submicron inorganic oxide compositions for transparent electrodes 发明人:JAISWAL ABHISHEK; ERNST FRANK O; CHIRUVOLU SHIVKUMAR; LEE JIA X; BUCHEL ROBERT; PRATSINIS SOTIRIS E 权利人:JAISWAL ABHISHEK; ERNST FRANK O; CHIRUVOLU SHIVKUMAR; LEE JIA X; BUCHEL ROBERT; PRATSINIS SOTIRIS E 摘要:Flame spray pyrolysis can be performed using aqueous solvents for the delivery of metal and/or metalloid oxide precursors while obtaining desirably high flame temperatures for the synthesis of uniform submicron inorganic oxide particles. A multiple liquid channel nozzle can be used to deliver liquid for the formation of the aerosol that is combusted in the flame. One or both channels can deliver liquid with metal/metalloid precursors and/or organic fuels. Flame spray pyrolysis can be used to form metal tungsten oxide submicron particles. Metal tungsten oxide compositions can be used in the formation of transparent electrodes. If the transparent electrodes are formed from polymer inorganic particle composites, the composites can further comprise electrically conductive nanoparticles to improve the electrical conductivity.
专利号:US-2022265691-A1 优先权日:2019-07-12 标 题 :Methods for use of gene expression as an indicator of e-selectin inhibitor efficacy and clinical outcome for multiple tumor types 发明人:MAGNANI JOHN L; FOGLER WILLIAM E; THACKRAY HELEN M; FELDMAN ERIC J; STEWART DAVID 权利人:GLYCOMIMETICS INC 摘要:Cancer patients that express high levels of the E-selectin ligand (sialyl Lea/x) on their tumors have a poorer outcome. Interestingly, relapsed/refractory acute myeloid leukemia (AML) patients expressing high levels of sialyl Lex on their blasts show the greatest therapeutic response when treated with the E-selection inhibitor compound of Formula I. Transcriptome profiling of E-selectin ligand-forming glycosylation genes showed that ST3GAL4 and FUT7 were consistently expressed in the majority of cancers evaluated. Poor survival outcomes of FLT3-mutated AML patients that express high levels of ST3GAL4 and FUT7 implicated E-selectin in this disease state. These genes may be predictive biomarkers in AML patients. Methods of treatment of cancer comprising screening AML patients for expression of genes that contribute to the synthesis of the E-selectin ligand sialyl Lex, then treating those patients with an E-selection inhibitor, are disclosed.