合成目标产物 Meglumine 主要起始原料 D(+)-Glucose And Methylamine
6284-40-8 + 1184581-58-5 = 6284-40-8 + 594839-88-0 反应条件:1.1 Reagents: Trifluoromethanesulfonic Acid; Rt -> 110 °C1.2 Reagents: Triethylamine; 60 - 80 °C 标题:Novel Crystalline Form Of Tafamidis And Its Process Thereof 参考文献:India]
6284-40-8 + 1395964-06-3 = 6284-40-8 + 594839-88-0 反应条件:1.1 Reagents: Lithium Hydroxide Solvents: Methanol,Tetrahydrofuran,Water; 25 - 35 °C1.2 Reagents: Hydrochloric Acid Solvents: Water; 2 H,Ph 1.5 - 2,25 - 35 °C1.3 Solvents: Isopropanol,Water; 25 °C -> 75 °C 标题:An Improved Process For The Preparation Of Tafamidis And Tafamidis Meglumine 参考文献:India]
6284-40-8 + 594839-88-0 = 6284-40-8 + 594839-88-0 反应条件:1.1 Solvents: Acetone; 2 H,55 - 65 °C 标题:Novel Process For The Preparation Of 6-Carboxy-2-(3,5-Dichlorophenyl)-Benzoxazole And Its Pharmaceutically Acceptable Salts 参考文献:India]
80529-93-7 = 6284-40-8 + 80529-93-7 反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Water; Ph 7,Rt 标题:Graphene Oxide Enhances Cellular Delivery Of Hydrophilic Small Molecules By Co-Incubation 作者:Hung,Andy H.; Holbrook,Robert J.; Rotz,Matthew W.; Glasscock,Cameron J.; Mansukhani,Nikhita D.; Et Al 参考文献:Acs Nano 日期:2014 卷标:8(10) 页码:10168-10177]
专利号:US-10941124-B2 优先权日:2015-12-18 标题 :DOTA synthesis 发明人:MEIJER ANDREAS RICHARD; AABYE ARNE WANG; HUSSAIN KHALID; NILSEN SONDRE; THANING MIKKEL JACOB; HAUGAN JARLE ANDRE; GAUSEMEL INGVIL; ENES NIKOLAI; SUMIHAR SILALAHI 权利人:GE HEALTHCARE AS 摘要:The present invention provides methods for the preparation of compounds useful in in vivo therapeutic and diagnostic applications. In particular, the present invention provides a method for the synthesis of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) and also methods for the preparation of metal chelates of DOTA.
专利号:US-2006058532-A1 优先权日:2004-09-10 标 题:Process for the scalable synthesis of 1,3,4,9-tetrahydropyrano[3,4-b]-indole derivatives 发明人:CHEW WARREN; CHEAL GLORIA K; LUNETTA JACQUELINE F; DEMERSON CHRISTOPHER A 权利人:CHEW WARREN; CHEAL GLORIA K; LUNETTA JACQUELINE F; DEMERSON CHRISTOPHER A 摘要:The invention is directed to a process of synthesizing compounds of formula (VI): n n nwherein R 1- R 9 , R 3′ , R 4′ and Y are as set forth in the specification, and said method is useful for large scale synthesis thereof. The invention is also directed to useful intermediates for synthesizing the compounds of formula (VI) and processes of preparing said intermediates.
专利号:US-9777022-B2 优先权日:2012-10-02 标题 :Process for the preparation of macrocyclic polyazacarboxylate ligands and chelates 发明人:MOORE DENNIS A; RAJAGOPALAN RAGHAVAN 权利人:MALLINCKRODT LLC; GUERBET SA 摘要:The present disclosure relates generally to a process for the synthesis of 1,4,7,10-tetraazacyclododecane ligands, chelates, and derivatives thereof. In particular, the present disclosure is directed to a process for the synthesis of 1,4,7,10-tetraaza-1,4,7,10-tetrakis(carboxymethyl)cyclododecane (DOTA) ligands, corresponding DOTA-metal chelates, and various derivatives thereof.
专利号:US-7307162-B2 优先权日:2003-09-26 标题:Resolution of a narwedine amide derivative 发明人:SCHLOEMER GEORGE; HSIAO TSUNG-YU 权利人:SCINOPHARM TAIWAN LTD 摘要:The present invention provides for an efficient method of effecting the resolution of a narwedine amide, and the synthesis of galantamine.
专利号:WO-2019049138-A1 优先权日:2017-09-11 标题:Methods for synthesis of resolvins 发明人:JAGTAP PRAKASH; SALZMAN ANDREW LURIE 权利人:SALZMAN INVEST LTD 摘要:The present invention relates to methods of chemically synthesizing a resolvin compound such as resolvine E1 (RvE1), or a pharmaceutically acceptable salt thereof; and chemically stable formulations of said compound.
专利号:WO-9522519-A1 优先权日:1994-02-17 标题 :Synthesis of polyhydroxy fatty acid amides from triglycerides 发明人:SCHEIBEL JEFFREY JOHN; REILMAN RANDALL THOMAS; SHERMAN JOE FREDERICK 权利人:PROCTER & GAMBLE 摘要:Fats and oils such as hardened palm kernel oil are reacted directly with N-substituted polyhydroxy amines to provide high yields of N-substituted polyhydroxy fatty acid amide surfactants having improved odors and low fatty acid content. Hardened palm kernel oil is reacted with N-methylglucamine in the presence of an ethoxylated alcohol, but in the absence of methanol solvent, using sodium propylene glycolate catalyst to provide the mixed corresponding fatty acid amide of N-methylglucamine.
1: Navaei A, Rasoolian M, Momeni A, Emami S, Rafienia M. Double-walled microspheres loaded with meglumine antimoniate: preparation, characterization and in vitro release study. Drug Dev Ind Pharm. 2014 Jun;40(6):701-10. doi: 10.3109/03639045.2013.777734. Epub 2013 Apr 17. doi: 10.1016/j.yrtph.2015.09.018. Epub 2015 Sep 14. doi: 10.1007/s00436-013-3685-8. Epub 2013 Nov 30. doi: 10.1016/j.ejrad.2014.03.030. Epub 2014 Apr 13. 6: Gutiérrez J, Vallejo B, Barbosa H, Pinzón J, Delgado G. In vitro analysis regarding the safety of components used in a film-based therapeutic system loaded with meglumine antimoniate and its activity toward Leishmania major experimental infections: a preliminary study. Immunopharmacol Immunotoxicol. 2013 Jun;35(3):321-8. doi: 10.3109/08923973.2013.768635. Epub 2013 Mar 11. doi: 10.1097/RLI.0b013e31827752b4. 8: Rubiano LC, Miranda MC, Muvdi Arenas S, Montero LM, Rodríguez-Barraquer I, Garcerant D, Prager M, Osorio L, Rojas MX, Pérez M, Nicholls RS, Gore Saravia N. Noninferiority of miltefosine versus meglumine antimoniate for cutaneous leishmaniasis in children. J Infect Dis. 2012 Feb 15;205(4):684-92. doi: 10.1093/infdis/jir816. Epub 2012 Jan 11.
合成参考文献
参考文献:10.3341/kjo.2010.24.1.40 摘要:Yaghoobi R, Maraghi S, Bagherani N, Rafiei A. Cutaneous leishmaniasis of the lid: a report of nine cases. Korean J Ophthalmol. 2010 Feb;24(1):40–3. 参考文献:10.1155/2011/269515 摘要:Yazdanpanah MJ, Banihashemi M, Pezeshkpoor F, Khajedaluee M, Famili S, Tavakoli Rodi I, Yousefzadeh H. Comparison of Oral Zinc Sulfate with Systemic Meglumine Antimoniate in the Treatment of Cutaneous Leishmaniasis. Dermatology Research and Practice. 2011;2011():1–4. doi: 10.1155/2011/269515. 参考文献:10.1007/s00232-011-9382-6 摘要:Nazıroğlu M, Özgül C, Çiğ B, Doğan S, Uğuz AC. Glutathione Modulates Ca2+ Influx and Oxidative Toxicity Through TRPM2 Channel in Rat Dorsal Root Ganglion Neurons. The Journal of Membrane Biology. 2011 Jul 12;242(3):109. doi: 10.1007/s00232-011-9382-6. 参考文献:10.1002/jmri.22713 摘要:Frydrychowicz A, Nagle SK, D'Souza SL, Vigen KK, Reeder SB. Optimized high-resolution contrast-enhanced hepatobiliary imaging at 3 tesla: a cross-over comparison of gadobenate dimeglumine and gadoxetic acid. J Magn Reson Imaging. 2011 Sep;34(3):585–94. 参考文献:10.1152/jn.00403.2011 摘要:Carlson SL, Fieber LA. Physiological evidence thatd-aspartate activates a current distinct from ionotropic glutamate receptor currents inAplysia californicaneurons. Journal of Neurophysiology. 2011 Oct;106(4):1629–36. doi: 10.1152/jn.00403.2011.