2-甲基噻吩置于n-溴代丁二酰亚胺(Nbs),高氯酸体系中,用84%的收率获得产物2-溴-5-甲基噻吩 参考文献:Functionalization Of Photochromic Dithienylmaleimides 标题:Functionalization Of Photochromic Dithienylmaleimides 摘要:报道了在三个不同位置对光致变色二噁英基马来酰亚胺进行官能化的合成路线. DOI:10.1039/c5Ra00015G
专利信息
专利号:US-8450503-B2 优先权日:2002-08-09 标题:Photochromic and electrochromic compounds and methods of synthesizing and using same 发明人:BRANDA NEIL R; PETERS ANDREA; WIGGLESWORTH ANTHONY J 权利人:BRANDA NEIL R; PETERS ANDREA; WIGGLESWORTH ANTHONY J; SWITCH MATERIALS INC 摘要:This invention relates to novel photochromic and electrochromic monomers and polymers based on 1,2-dithienylcyclopentene derivatives and method of using and synthesizing same. The compounds are reversibly interconvertible between different isomeric forms under suitable photochromic or electrochromic conditions. The electrochromic conversion may be catalytic. The application also relates to ultra-high density homopolymers prepared using ring-opening methathesis polymerization (ROMP) where the central ring of the 1,2-bis(3-thienyl)-cyclopentene is incorporated directly into the polymer backbone. The monomer units may be readily functionalized to enable the synthesis of polymers with diverse structural and electronic properties. The compounds have many potential applications including high-density optical information storage systems, photoregulated molecular switches, reversible holographic systems, ophthalmic lenses, actinometry and molecular sensors, photochromic inks, paints and fibers and optoelectronic systems such as optical waveguides, Bragg reflectors and dielectric mirrors.
专利号:US-9663594-B2 优先权日:2014-05-15 标 题 :Synthesis of aryl coupled bis phenoxides and their use in olefin polymerization catalyst systems with activator-supports 发明人:HLAVINKA MARK L 权利人:CHEVRON PHILLIPS CHEMICAL CO LP; CHEVRON PHILIPS CHEMICAL COMPANY LP 摘要:Disclosed herein are methods of making bis(phenol) ligand compounds and transition metal bis(phenolate) compounds. The transition metal bis(phenolate) compounds can be used as components in catalyst systems for the polymerization of olefins.
专利号:US-2021074930-A1 优先权日:2019-09-06 标题 :Synthesis of ft4-based organic semiconducting small molecules by pd-catalyzed direct (hetero)arylation or direct alkenylation 发明人:HE MINGQIAN; LI YANG; SUN JING; WANG HONGXIANG; ZHOU MONG-DONG 权利人:CORNING INC; UNIV LIAONING SHIHUA 摘要:A method for forming organic semiconducting materials, including: providing a mixture having: a tetrathienoacene (FT4)-based monomer, and one of a thiophene-containing compound or an alkene-containing compound; and reacting the FT4-based monomer with the thiophene-containing compound or the alkene-containing compound in a one-step direct arylation reaction mechanism to form a final FT4-based organic semiconducting compound.
专利号:US-7129361-B2 优先权日:1998-04-15 标 题 :Thienylazolylalkoxyethanamines, their preparation and their application as medicaments 发明人:MERCE-VIDAL RAMON; ANDALUZ-MATARO BLAS; FRIGOLA-CONSTANSA JORDI 权利人:ESTEVE LABOR DR 摘要:The thienylazolylalkoxyethanamines (I) where R1 is a hydrogen atom, a halogen atom or a lower alkyl radical; R2, R3 and R4 represent, independently, a hydrogen atom or a lower alkyl radical; and Az represents a five-member nitrogenated hetercyclic aromatic group, N-methyl-substituted, that contains from one to three nitrogen atoms. They have analgesic activity in mammals, including humans. The compounds (I) can be obtained, for example, by reaction of a derivative of hydroxy-thienylazol (IV) with a derivative of a suitable N-(ethyl)amine. The compounds (IV) are useful intermediates in the synthesis of the compounds (I). The compounds (I) have an application in human and/or veterinary medicine.
专利号:WO-2006127595-A1 优先权日:2005-05-23 标题:5-aminopyrazole carboxylic acid derivatives and methods of treatment of metabolic-related disorders thereof 发明人:SKINNER PHILIP J; SEMPLE GRAEME; WEBB PETER 权利人:ARENA PHARM INC; SKINNER PHILIP J; SEMPLE GRAEME; WEBB PETER 摘要:The present invention relates to certain pyrazole carboxylic acid or ester derivatives of Formula (I) and pharmaceutically acceptable salts thereof which exhibit useful pharmacological properties, for example, as agonists for the GPCR referred to herein as RUP38. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of metabolic-related disorders, such as, dyslipidemia, atherosclerosis, coronary heart disease, insulin resistance, type 2 diabetes, Syndrome-X and the like. In addition, the present invention also provides for the use of the compounds of the invention in combination with other active agents such as those belonging to the class of -glucosidase inhibitors, aldose reductase inhibitors, biguanides, HMG-CoA reductase inhibitors, squalene synthesis inhibitors, fibrates, LDL catabolism enhancers, angiotensin converting enzyme (ACE) inhibitors, insulin secretion enhancers and the like.
专利号:US-11401284-B2 优先权日:2018-08-30 标题:Organic semiconducting material and its synthesis and organic semiconducting component with the material 发明人:MIRLOUP ANTOINE; D'SOUZA DANIEL; FITZNER ROLAND; GERDES OLGA; HILDEBRANDT DIRK; MATTERSTEIG GUNTER; WEISS ANDRE 权利人:HELIATEK GMBH 摘要:New absorbing materials of formula (I) for use in organic semiconducting components:
参考标题:Synthesis Of 4-Substituted Chlorophthalazines, Dihydrobenzoazepinediones, 2-Pyrazolylbenzoic Acid, And 2-Pyrazolylbenzohydrazide Via 3-Substituted 3-Hydroxyisoindolin-1-Ones 作者:Hanh Nho Nguyen,Victor J. Cee,Holly L. Deak,Bingfan Du,Kathleen Panter Faber,Hakan Gunaydin,Brian L. Hodous,Steven L. Hollis,Paul H. Krolikowski,Philip R. Olivieri,Vinod F. Patel,Karina Romero,Laurie B. Schenkel,Stephanie D. Geuns-Meyer |发布日期:2012.4.20 摘要:Hydrazine, Followed By Chlorination With Pocl3. We Have Also Discovered Two Novel Transformations Of 3-Vinyl- And 3-Alkynyl-3-Hydroxyisoindolinones. Addition Of Vinyl Organometallic Reagents To N,N-Dimethylaminophthalimide (8A) Provided Dihydrobenzoazepinediones 15A-15C Via The Proposed Ring Expansion Of 3-Vinyl-3-Hydroxyisoindolinone Intermediates. 3-Alkynyl-3-Hydroxyisoindolinones React With Hydrazine And
合成参考文献
摘要:Lubell, W. D.; St-Cyr, D. J.; Dufour-Gallant, J.; Hopewell, R.; Boutard, N.; Kassem, T.; Dörr, A.; Zelli, R., Science of Synthesis Knowledge Updates, (2013) 1, 315. 摘要:Jie, X.; Su, W., Science of Synthesis, (2022) , 44. 摘要:Le Bras, J.; Muzart, J., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 3, 170.